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Application of sesquiterpenoids in preparing mite killing medicine

A technology of sesquiterpenoids and compounds, which is applied in the field of application of sesquiterpenoids in the preparation of acaricidal drugs, and can solve the problems of no compounds with acaricidal activity

Inactive Publication Date: 2013-11-13
SICHUAN AGRI UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0006] At present, there is no report on the acaricidal activity of this compound

Method used

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  • Application of sesquiterpenoids in preparing mite killing medicine
  • Application of sesquiterpenoids in preparing mite killing medicine
  • Application of sesquiterpenoids in preparing mite killing medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0039] The acquisition of embodiment 1 sesquiterpenoids

[0040] Obtaining Eupatorium adenophorum petroleum ether extract: Eupatoria adenophorum whole herb dry powder was obtained by drying Eupatoria adenophorum collected in Xichang City, Sichuan Province naturally and then crushing. Take 8kg of Eupatorium adenophorum whole herb dry powder, extract it three times with 8-10 times of 95% ethanol heat reflux respectively, and then combine the extracts and concentrate under reduced pressure to obtain the ethanol extract of Eupatorium adenophorum. The obtained Eupatorium adenophorum ethanol extract was dispersed in 4 L of water, extracted three times with 4 L of petroleum ether, and separated to obtain petroleum ether extract.

[0041] Sample mixing: Take 48g of the obtained petroleum ether extract, add a proper amount of acetone until it dissolves. Weigh 98g of 200-300 mesh column chromatography silica gel and put it in an evaporating dish, put the evaporating dish on a water bat...

Embodiment 2

[0054] The in vitro insecticidal activity of embodiment 2 sesquiterpenoids is measured

[0055] Isolate and collect scabs from the ear canal of New Zealand rabbits severely infected with itchy mite, place them in a glass plate, and place the plate in a 35°C incubator for 0.5h-1h. After crawling out from the scab, the vigorous itchy mite that crawled out was picked for the experiment.

[0056] The sesquiterpenoids with the structure obtained in Example 1 as shown in formula I were tested for in vitro insecticidal activity,

[0057]

[0058] The experiment consisted of an experimental group, a blank control group and a positive control group. Wherein, the reagent used in the experimental group is the sesquiterpenoid solution obtained in Example 1 of different concentrations, in g / mL, the mass volume concentration of the sesquiterpenoid compound with the structure shown in formula I in the reagent used in the experimental group is respectively 0.5%, 0.25%, 0.125%, 0.06%, the...

Embodiment 3

[0070] The clinical treatment of embodiment 3 sesquiterpenoids to rabbit itch mite

[0071] In order to further verify the clinical therapeutic effect of the sesquiterpenoids with the structure shown in formula I on animal acariasis, the sesquiterpenoids with the structure shown in formula I obtained in Example 1 are used to treat rabbit itches treatment of mites,

[0072]

[0073] Randomly select 30 New Zealand rabbits infested with itch mite from the rabbit farm where itch mite broke out. The selected New Zealand rabbits are of similar age and weight, and the degree of infection in the left ear and right ear is similar. Treat with other miticides. At the same time, the New Zealand rabbits selected for testing were in good immunity and had no infection with other diseases. The selected 30 rabbits were randomly divided into 5 groups, 6 rabbits in each group, respectively marked as group A, group B, group C, group D and group E for testing. Simultaneously, in order to eva...

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Abstract

The invention relates to the field of medicinal chemistry, and discloses an application of sesquiterpenoids in preparing a mite killing medicine and a mite killing medicine comprising the sesquiterpenoids. According to the application of sesquiterpenoids in preparing a mite killing medicine, disclosed by the invention, the structure of the adopted sesquiterpenoids is shown by the formula I. When applied to mite killing, the sesquiterpenoids have an obvious mite killing effect and realize a killing effect on animal mites; the sesquiterpenoids belong to natural plant-source mite killing medicines, and have the characteristics that drug resistance is avoided, the sesquiterpenoids can be self-degraded in the environment, are not left in an animal product or enriched through a food chain and are relatively safe to human bodies, animals and the environment and the like; and the sesquiterpenoids can be used for preparing a mite killing medicine.

Description

technical field [0001] The invention relates to the technical field of medicinal chemistry, in particular to the application of a sesquiterpene compound in the preparation of acaricides. Background technique [0002] Mites (Acarid) belong to invertebrates, Arthropoda, Arachnida, and subclass Acarid. Most mites are soft and very small, and can be seen with the naked eye, generally 0.1 mm to several mm. At present, there are about 50,000 kinds of known mites, which parasitize underground, on the ground, in mountains, in water, and on people or organisms, infecting various diseases or endangering crops. Animal acariasis is a kind of contact, contagious and intractable skin disease caused by mites of Scabies, Pythrocarpiidae and Demodexidae parasitizing on the skin of animals, characterized by severe itching and severe skin inflammation of sick animals. feature. Animal mite disease spreads all over the world. It is commonly known as "mange" in Chinese folk. It generally occurs...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/122A61P33/14
Inventor 杨光友农向古小彬彭雪蓉
Owner SICHUAN AGRI UNIV
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