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Glycerophospholipids containing omega-3 and omega-6 fatty acids

A technology of serine glycerophospholipids and glycerophospholipids, applied in medical preparations containing active ingredients, food preparation, food science, etc., can solve problems that are not necessary for cell differentiation, proliferation and regeneration, and strong fishy smell

Inactive Publication Date: 2013-11-06
ENZYMOTEC
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0027] 2. It is not necessary for cell differentiation, proliferation and regeneration
Despite the health image, one issue perceived by consumers is the strong fishy odor produced

Method used

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  • Glycerophospholipids containing omega-3 and omega-6 fatty acids
  • Glycerophospholipids containing omega-3 and omega-6 fatty acids
  • Glycerophospholipids containing omega-3 and omega-6 fatty acids

Examples

Experimental program
Comparison scheme
Effect test

preparation example Construction

[0164] The preparation of pharmaceutical compositions is well known in the art and is described in numerous documents and reference works, see, eg, Gennaro A.R. ed. (1990) Remington's Pharmaceutical Sciences, Mack Publishing Company, Easton, Pennsylvania, especially pages 1521-1712 therein.

[0165] As a food additive, the preparation of the present invention can be used in the form of soft capsules, tablets, syrups or any other common dietary supplement delivery system.

[0166] As a functional food, the product of the present invention can be incorporated and used in various foods such as dairy products, ice cream, biscuits, soy products, pastries and breads, soy sauces, seasonings, oils and fats, margarines, sauces, cereals, Beverages and mixed drinks, infant formula, baby food (biscuits, purees and fruit purees, cereals), food bars, snacks, confectionery, chocolate products.

[0167] As a pharmaceutical product, the preparation of the present invention can be delivered ora...

Embodiment 1

[0181] method

[0182] animals and feed

[0183] Male Wistar rats originating from the same population were obtained by Harlen. 50 rats were randomly divided into 5 feed supplement groups. In addition to normal feed, there were: (i) a group (MCT group) fed with 0.1g medium-chain triglyceride (MCT) / 1ml supplementary matrix; (ii) ) group fed 0.1 g DHA / EPA (20 / 30% total fatty acid composition, diluted with MCT, yielding 30% (w / w) LC-PUFA compound) triglycerides / 1 ml supplemented matrix (LC-PUFA group); (iii) group fed 0.1 g soybean lecithin-derived PS (20% SB-PS w / w) / 1 ml supplemented matrix (SB-PS group); and (iv) fed 0.1 g PS-ω3 (20% PS w / w, 30% total LC-PUFA composition) / 1 ml group supplemented with matrix (PS group). Supplemented matrix was stored at -20°C and rats were fed fresh portions daily. All supplements are processed to minimize fatty acid oxidation. Rats were given feed and water ad libitum. All rats were housed in a standard environment in which the temperatur...

Embodiment 2

[0205] Embodiment 2—PS-ω3 treats ADHD child

[0206]Attention-deficit / hyperactivity disorder (ADHD) comprises a broad group of behavioral and learning problems whose definition and diagnosis remain controversial [Kamper(2001) J.Pediatr.139:173-4; Richardson et al.(2000) Prostaglandins Leukot.Essent . Fatty Acids, 63(1-2):79-87]. The etiology of ADHD is recognized to be complex and multifactorial. ADHD has traditionally been a diagnosis used to describe children who are inattentive, impulsive, and / or hyperactive. Roughly speaking, 20-25% of children with ADHD show a loss of one or more specific learning abilities in mathematics, reading or spelling [Barkley, R.A. (1990) Attenation-deficit hyperactivity disorder: a handbook for diagrzosis arld treatment. New York: Guilford Press]. Children with ADHD often have trouble learning and concentrating and can be disorganized, have poor self-discipline, and have low self-esteem. It is conservatively estimated that 3-5% of the school...

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Abstract

Disclosed is a lipid preparation comprising a glycerophospholipid or salt, conjugate and derivatives thereof, particularly phosphatidylserine (PS), phosphatidylcholine (PC), phosphatidylethanolamine (PE), phosphatidylinositol (PI), phosphatidylglycerol (PG) and phosphatidic acid (PA), and poly-unsaturated fatty acid (PUFA) acyl groups, particularly long-chain poly-unsaturated fatty acid (LC-PUFA) acyl groups such as omega-3 and / or omega-6 acyl groups, wherein said PUFA is covalently bound to said glycerophospholipid. The disclosed preparations possess an improved bioactivity, and are useful in the treatment of various cognitive and mental conditions and disorders and for maintenance of normal functions of brain-related systems and processes, for example ADHD.

Description

[0001] This application is a divisional application of a patent application with an application date of October 21, 2004, an application number of 200480038107.X, and an invention title of "Glycerophospholipids Containing Omega-3 and Omega-6 Fatty Acids". technical field [0002] The present invention relates to preparations of phospholipids and polar lipids enriched in omega-3 and / or omega-6 fatty acids covalently attached to the lipid backbone. Specifically, the phospholipid preparation of the present invention can be used as nutritional supplement food, food additive and / or medicament to treat various diseases, especially diseases related to cognitive function. Background technique [0003] Lipids, especially polar lipids, nitrogen-containing lipids and carbohydrate-containing lipids (phospholipids, sphingosines, glycolipids, ceramides, sphingomyelin), are the main structural units of cell membranes, tissues, etc. In addition, they also play an important role in signal tr...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/685A61P25/28A61P25/14A23L1/29A23L17/20A23L33/00A61K31/683
CPCA61K31/683A61K31/685A61P1/00A61P1/16A61P13/12A61P15/12A61P17/00A61P25/00A61P25/14A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P27/02A61P29/00A61P35/00A61P3/06A61P37/00A61P37/02A61P37/08A61P39/06A61P7/10A61P9/08A61P9/10A61P9/12A61P3/10A23L33/00
Inventor G·本德洛D·普拉特O·法卡什R·佐比Z·巴-安A·舒尔曼D·佩勒德
Owner ENZYMOTEC
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