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Use of icariin in prevention and treatment of traumatic brain injury

A technology of icariin and brain injury, which is applied in the field of pharmacy to achieve the effect of reducing brain water content, improving neurobehavioral function, and good therapeutic effect

Inactive Publication Date: 2013-10-16
ZUNYI MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

There are no reports on the protective effect of ICA on traumatic brain injury

Method used

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  • Use of icariin in prevention and treatment of traumatic brain injury
  • Use of icariin in prevention and treatment of traumatic brain injury
  • Use of icariin in prevention and treatment of traumatic brain injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0041] Embodiment 1 of the present invention: get 5 g of icariin, 75 g of medicinal starch, and 20 g of microcrystalline cellulose, dry the medicinal starch first, pass through a 120 mesh sieve, and then mix with icariin and microcrystalline cellulose Mix, pass twice 120 mesh sieves, fill in the hard capsule, make 1000 capsules of the present invention. Each hard capsule contains 0.5 mg of the main ingredient.

Embodiment 2

[0042] Embodiment 2 of the present invention: icariin 5g, hypromellose 6g, sodium starch glycolate 10g, microcrystalline cellulose 8g, lactose 115g, starch 50g, magnesium stearate 1g; After mixing, put it into a high-speed blender, spray and add appropriate amount of water, granulate, control the water content at 3~4%, and then compress into tablets to make 1000 tablets, coated with film.

Embodiment 3

[0043] Example 3 of the present invention: Add 5 g of icariin, add 400 ml of polyethylene glycol 200 to dissolve, then add an appropriate amount of distilled water to dilute, then add an appropriate amount of sucrose and adjust the volume to 1000 ml, stir well, filter, and fill into 10 ml or 20 ml each, sterile packaged.

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Abstract

The present invention discloses an application of icariin in preparation of drugs for prevention and treatment of traumatic brain injury. According to the present invention, icariin is adopted to prepare drugs for prevention and treatment of traumatic brain injury, a multi-target point nerve protection effect of the icariin is utilized, and in vivo animal experiment results show that the icariin has a significant neuroethology improvement function, and has effects of significant brain water content decrease, significant TNF-alpha mRNA expression decrease, and significant IL-1beta mRNA expression decrease; and the new use of the specific monomer icariin in the known Chinese herbal epimedium in preparation of drugs for prevention and treatment of traumatic brain injury is explored, and the new application field is developed.

Description

technical field [0001] The invention belongs to the field of pharmacy, in particular to the application of the multi-target neuroprotective effect of icariin in the preparation of a pharmaceutical composition for preventing and treating traumatic brain injury. Background technique [0002] Traumatic brain injury is one of the important causes of clinical death and disability, and has become an important disease that threatens people's lives, causing great economic and psychological burdens on society and patients' families. TBI is a primary brain injury caused by direct mechanical force acting on brain tissues such as neurons, axons, glial cells, and blood vessels. The clinical manifestations are headache, dizziness, nausea and vomiting, retrograde amnesia, and disturbance of consciousness; post-injury Secondary brain injury is induced in minutes or hours on the basis of primary brain injury, and a series of cell, neurobiochemical and metabolic changes occur. Irritability, ...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P25/00
Inventor 石京山陈澜龚其海李明刚
Owner ZUNYI MEDICAL UNIVERSITY
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