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Gel and use thereof

A technology of gel and gel matrix, which is applied in the field of medicine, can solve the problems of unsatisfactory treatment effect and high recurrence rate, and achieve the effect of regulating the microecological balance of the vagina or skin

Active Publication Date: 2013-09-25
海南世宝康医疗科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] There are many treatment products on the market for the above common female reproductive tract infections (including high-risk HPV infection), cervicitis, and cervical erosion, but the treatment effect is not ideal, and the recurrence rate is high

Method used

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  • Gel and use thereof
  • Gel and use thereof
  • Gel and use thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 3

[0092] Table 4 Example 3 product to MIC and MBC of standard bacterial strain

[0093]

[0094] As can be seen from the above table, the gel agent of the present invention (composition composed of polysaccharide polymer, hyaluronic acid substance and lactic acid substance) is effective for the selected Escherichia coli, Staphylococcus aureus, Pseudomonas aeruginosa Marked strains of Monomonas, Staphylococcus epidermidis, Proteus vulgaris, Streptococcus faecalis, Neisseria gonorrhoeae and clinical reference strains of Gardnerella vaginalis all had obvious inhibitory and inactivation effects, and their MBC was MIC 2 to 4 times.

[0095] Table 5 embodiment 3 product is to 405 strains of clinical isolate bacterial strains

[0096] MIC, MIC 50 、MIC 99 and MBC (mg composition / ml)

[0097] strain

Number of plants

Mic

Mic 50

Mic 99

MBC

Escherichia coli

120

6.25～50

18.1693

22.7543

25～100

Proteus

100

12.5～5...

Embodiment 1

[0102] prescription

[0103]

[0104] Preparation

[0105] ①. Dissolve carboxychitin in acetic acid aqueous solution with pH 4.0, fully swell and set aside;

[0106] ②. Add sodium hyaluronate to appropriate purified water, fully swell and add for later use;

[0107] ③. Dissolve carbomer in an appropriate amount of purified water, fully swell and add for use;

[0108] ④. Add the solution obtained in step ① and step ② into the same container, stir and mix well, and set aside;

[0109] ⑤. Add the carbomer aqueous solution obtained in step ③ into the container described in step ④, fully stir and mix;

[0110] ⑥, add lactic acid to the solution obtained in step ⑤, and fully stir and mix;

[0111] ⑦. Add glycerol and purified water to the solution obtained in step ⑥, fully stir and mix evenly, and fill to obtain.

Embodiment 2

[0113] prescription

[0114]

[0115] Preparation

[0116] After the above raw materials are placed in a stirrer and fully stirred and swelled, a chitosan hyaluronic acid lactic acid gel is obtained.

[0117] Example 3

[0118] prescription

[0119]

[0120] After the above raw materials are placed in a stirrer and fully stirred and swelled, they are filled to obtain a chitosan hyaluronic acid lactic acid gel.

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PUM

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Abstract

The invention belongs to the technical field of medicines, and discloses a gel and a use thereof. The gel comprises a chitosan polymer, a hyaluronic acid matter, a lactic acid matter, a gel matrix, a wetting agent and a diluter. The gel has the advantages of good antibacterial effect, wide antibacterial spectrum (comprising high risk HPV (Human Papilloma Virus), physical antibacterial effect, no tolerance, biodegradability, safety and environment-friendliness and lasting effect for a long time, and has the functions of nourishing, lubricating, whitening, repairing skins or mucosal tissues, and removing spots and inhibiting cicatrisation for skins or mucosal tissues.

Description

technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to a gel and its application. Background technique [0002] Vaginitis and cervicitis are persistent inflammations of the female reproductive tract. They usually occur in women of reproductive age. They are the most common diseases in gynecology. They are often caused by incomplete treatment or treatment against pathogens, which makes the disease protracted. Modern medicine has confirmed that bacterial and viral infections are one of the main causes of vaginitis, cervicitis and cervical erosion. HPV), Chlamydia trachomatis (CT), herpes simplex virus (HSV-n), etc., among which HPV plays a leading role in many etiologies. And HPV is closely related to cervical intraepithelial neoplasia (CIN) and cervical cancer, and cervical erosion can develop into cervical cancer through CIN. [0003] Cervical polyps are also one of the most common diseases of women's cervical lesions,...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/728A61K31/722A61K31/737A61K31/19A61K9/06A61P15/02A61P15/00A61P9/14A61P29/00A61P17/00A61P17/02A61P31/00A61P33/00A61P31/20A61P31/04A61K8/04A61K8/73A61K8/86A61K8/365A61Q19/00A61Q19/02A61L15/42A61L15/28A61L15/20A61L15/26
Inventor 康晓飞
Owner 海南世宝康医疗科技有限公司
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