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Pharmaceutical composition for treating hyperlipidemia as well as preparation method and applications

A technology for hyperlipidemia and composition, applied in the field of pharmaceutical compositions and preparations for treating hyperlipidemia, can solve problems such as inapplicability to general audiences, and achieve the effects of simple composition, lowering blood lipid levels, and clear mechanism of action

Inactive Publication Date: 2013-09-18
CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although this method has achieved satisfactory therapeutic effects in clinical treatment, it is only applicable to individual individuals and not to the general audience

Method used

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  • Pharmaceutical composition for treating hyperlipidemia as well as preparation method and applications
  • Pharmaceutical composition for treating hyperlipidemia as well as preparation method and applications
  • Pharmaceutical composition for treating hyperlipidemia as well as preparation method and applications

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0021] Embodiment 1: the extraction method of evodiamine

[0022] Weigh 100 grams of decoction pieces of Evodia rutaecarpa, crush to pass through a 60-mesh sieve, undergo ultrasonic treatment for 180-300s, and dry at 50-60°C at a low temperature, and place it in an extraction tank; add entraining agent absolute ethanol at a ratio of 4.2:100; Extraction pressure 19-20MPa, extraction temperature 35-40°C, CO 2 Separation was carried out under the condition of a flow rate of 2.0-3.0L / min. After 120-150 minutes of dynamic operation, 4.50g of crude evodiamine was obtained, and the yield of the crude product was 4.50%. Anhydrous ethanol was recovered, and the clean CO 2 The fluid is recycled in the device after being condensed by the condenser. The extracted evodiamine was purified by chromatography, the purification instrument was Anjie 1100, the column conditions were: C18 column, mobile phase: acetonitrile-water (42:55); flow rate: 1.0mL min -1 ;Column temperature: 40°C; Detecti...

Embodiment 2

[0024] Embodiment 2: the extraction method of berberine

[0025] Weigh 100 grams of Coptidis decoction pieces, crush them to pass through a 60-mesh sieve, put them into a 500ml round-bottomed flask, add 800ml of 75% ethanol, heat in a hot water bath at 60°C for 30min, leave to soak for 2h, suction filter, and repeat the above treatment for the filter residue twice. 3 times, the filtrates were combined for 3 times, and the ethanol was distilled off under reduced pressure until it was a brownish-red syrup. Add 1% acetic acid (about 30-40ml) to the brown-red syrup and heat to dissolve, filter with suction to remove insoluble matter, then add concentrated hydrochloric acid to the solution until the solution is cloudy, that is, berberine is precipitated, and then pumped Filter, wash the crystals twice with water and once with acetone, dry and weigh to obtain the refined product of berberine. Berberine purity ≥ 98%.

[0026] In addition to extracting berberine according to the abo...

Embodiment 3

[0028] Weigh 10 g of raw materials evodiamine and 50 g of berberine, add 200 g of auxiliary materials starch to granulate, 4 g of magnesium stearate, 100 g of dextrin, and 100 g of microcrystalline cellulose, uniformly prepare granules, and compress into tablets to obtain tablets.

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Abstract

The invention discloses a pharmaceutical composition for treating hyperlipidemia as well as a preparation method and applications. The pharmaceutical composition comprises the following ingredients in parts by weight: 1-10 parts of evodiamine, and 5-15 parts of berberine. The pharmaceutical composition is prepared by combining active ingredients of natural pharmaceutical raw materials or the extract of active ingredients of pharmaceutical raw materials, is simple in constituents, is affirmed for curative effect, is not required for being decocted for administration, is convenient to carry and take after being prepared into tablets, capsules, pills, granules and oral liquid. Compared with the traditional natural pharmaceutical formulation, the composition has the advantages of less impurity content, high purity, clear action mechanism and stable character, is capable of better controlling the product quality in industrialization, and the like.

Description

technical field [0001] The invention belongs to the field of medicines, and relates to a pharmaceutical composition for treating hyperlipidemia, in particular to a pharmaceutical composition and a preparation method for treating hyperlipidemia which are prepared from extracts of traditional Chinese medicine decoction pieces. Background technique [0002] Hyperlipidemia is a symptom of abnormally increased lipoproteins in the blood. It is one of the common diseases in the cardiovascular system. The main reason is that the lipid metabolism disorder in the body causes the decline of high-density lipoproteins, which reduces the ability to eliminate blood lipids. As a result, triglycerides and cholesterol in the blood increase, accompanied by symptoms such as obesity, chest tightness, heavy head, dizziness, abdominal distension, and loss of appetite. The disease is closely related to hypertension, hyperglycemia and aging, and is most closely related to the incidence of coronary h...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/519A61P3/06A61K31/4375
Inventor 沈涛徐世军薛红
Owner CHENGDU UNIV OF TRADITIONAL CHINESE MEDICINE
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