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Carboxyethyl chitosan fiber and preparation method thereof

The technology of chitosan fiber and carboxyethyl group is applied in the field of fiber material preparation, which can solve the problems of uncertain distribution position and quantity of substituents, difficult to effectively control the liquid absorption performance of the product, and no antibacterial property, etc., so as to reduce pain, Inhibition of bacterial growth on wound surfaces and increased effects of polycationic properties

Active Publication Date: 2015-06-24
JIANGSU NEWVALUE MEDICAL PROD CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

However, these modification methods, on the one hand, have harsh reaction conditions, cumbersome steps, and are not easy to control; on the other hand, the distribution position and quantity of substituents on the molecular chain of the product obtained from the reaction are uncertain, making it difficult to effectively control the liquid absorption performance of the product.
In addition, the above products do not have antimicrobial properties either
These problems will greatly limit the clinical application of dressings prepared from chitosan fibers, especially for burns and chronic wounds.

Method used

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  • Carboxyethyl chitosan fiber and preparation method thereof
  • Carboxyethyl chitosan fiber and preparation method thereof
  • Carboxyethyl chitosan fiber and preparation method thereof

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preparation example Construction

[0031] The preparation method of carboxyethyl chitosan fiber, described preparation method is carried out as follows:

[0032] a. Disperse chitosan fiber in alcohol, the mass volume ratio of chitosan fiber to alcohol is 1:10~50, then add acrylic acid to the mixture of chitosan fiber and alcohol, the amino group of acrylic acid and chitosan fiber The molar ratio is 1:0.1~20, stir evenly at room temperature, and react in a constant temperature water bath at 40~90°C for 4~48h; the alcohol is one of methanol, ethanol, propanol, butanol or isopropanol .

[0033] Generally speaking, chitosan is difficult to form polycations under neutral or alkaline conditions, and the antibacterial effect is weak. The present invention is through the Michael addition reaction of the amino group on the molecular chain of chitosan and the carbon-carbon double bond on the acrylic acid molecule. A carboxyethyl group is introduced on the N position. The carboxylic acid on the carboxyethyl group gives ...

Embodiment 1

[0042]Weigh 5 g of chitosan fibers and disperse them in 50 mL of methanol, add 22.38 g of acrylic acid, shake and stir at room temperature, react in a constant temperature water bath at 90°C for 48 hours, separate the reacted chitosan fibers from the reaction mixture, and separate The chitosan fibers produced were dispersed in 80% (v / v) methanol aqueous solution, and 30% (w / v) sodium hydroxide aqueous solution was added dropwise, the pH of methanol and sodium hydroxide aqueous solution mixture was adjusted to 7.3, soaked for 30 minutes, Then the soaked chitosan fibers were separated from the mixture, washed twice with 80% (v / v) methanol aqueous solution, dehydrated, and dried at 40°C to obtain 0.8 carboxyethyl chitosan fiber.

Embodiment 2

[0044] Weigh 5 g of chitosan fibers and disperse them in 250 mL of ethanol, add 0.11 g of acrylic acid, shake and stir at room temperature, react in a constant temperature water bath at 40°C for 4 hours, separate the reacted chitosan fibers from the reaction mixture, and separate The obtained chitosan fibers were dispersed in 80% (v / v) ethanol aqueous solution, and 30% (w / v) potassium hydroxide aqueous solution was added dropwise, and the pH of the mixture of ethanol and potassium hydroxide aqueous solution was adjusted to 8.0, soaked for 30 minutes, Then the soaked chitosan fiber is separated from the mixture, washed twice with 80% (v / v) ethanol aqueous solution, dehydrated, and dried at 40°C to obtain a fiber with a viscosity of 900 cps and a carboxyethyl substitution degree 0.01 carboxyethyl chitosan fiber.

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Abstract

The invention relates to a carboxyethyl chitosan fiber and a preparation method thereof and belongs to the field of preparation of a fiber material. The carboxyethyl chitosan fiber is characterized in that the chemical structural formula of the carboxyethyl chitosan fiber is shown as specification. The preparation method comprises the following steps of: dispersing a chitosan fiber into alcohol so as to obtain the carboxyethyl chitosan fiber by separating, washing and drying through Michael addition reaction with acrylic acid. The fiber has a good antibacterial property and high liquid absorption amount; and a prepared surgical dressing can be used for infectious wound surfaces with percolate, such as burns and scalds, and bedsores, so as to have the effects on inhibiting bacteria at the wound surfaces from growing, absorbing the percolate of the wound surfaces, and providing a wet healing environment to accelerate the wound surfaces to be healed. The preparation method of the carboxyethyl chitosan fiber is moderate in conditions, simple in process and low in cost, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a chitosan fiber and a preparation method thereof, in particular to a carboxyethyl chitosan fiber and a preparation method thereof, belonging to the field of fiber material preparation. Background technique [0002] Chitin is a renewable resource second only to cellulose in reserves on the earth. Its deacetylated derivative, chitosan, has good biocompatibility, biodegradability, hemostasis, and promotion of wound healing. Absorbable surgical sutures, wound dressings, drug carrier materials, artificial skin and other tissue engineering scaffold materials have broad application prospects. [0003] Dissolve chitosan in organic acid or inorganic acid to form viscous colloid. After spinning, coagulation, washing, drying and other processes, chitosan fiber can be obtained, which can be used to prepare wound dressings. Japanese Open Patent Publication (JP 60,059,123, 1985), Chinese Patent Publication No. CN1129748, the publication da...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D06M13/203D06M101/10
Inventor 周应山徐卫林施龙献李芳
Owner JIANGSU NEWVALUE MEDICAL PROD CO LTD
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