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A kind of composite sponge and preparation method thereof

A composite sponge and solution technology, applied in bandages, absorbent pads, medical science, etc., can solve problems such as poor absorption of exudate, weak anti-infection performance, poor wet strength, etc., to achieve enhanced repair, obvious antibacterial effect, The effect of high water absorption

Inactive Publication Date: 2020-01-14
WUHAN UNIV OF TECH
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although there are different types of dressings used in the treatment or nursing of chronic wounds clinically, they are all unsatisfactory and have some defects to varying degrees, such as weak anti-infection performance, drug allergy, poor ability to absorb exudate, and low wet strength. Poor, slow wound healing, etc.

Method used

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  • A kind of composite sponge and preparation method thereof
  • A kind of composite sponge and preparation method thereof

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preparation example Construction

[0021] The preparation method of chitosan quaternary ammonium salt of the present invention is:

[0022] 1) dissolving chitosan powder in glacial acetic acid solution, and then adding sodium hydroxide to the above solution to obtain chitosan precipitation; the precipitation is washed to pH=7.0;

[0023] 2) Disperse the above-mentioned treated chitosan in the isopropanol solution, and after the dispersion is complete, stir, heat and reflux to raise the temperature to 80°C;

[0024] 3) the Virahol solution that will contain 2,3-epoxypropyltrimethylammonium chloride is added dropwise in the above-mentioned solution; Control chitosan and 2,3-epoxypropyltrimethylammonium chloride The molar ratio is 1:4;

[0025] 4) The mixed solution was reacted at 80° C. for 24 hours, cooled, filtered, the filter cake was washed with absolute ethanol and ether in sequence, and vacuum-dried to obtain chitosan quaternary ammonium salt.

[0026] The preparation method of hyaluronic acid-RGD peptide...

Embodiment 1

[0029] Weigh 0.2g of chitosan quaternary ammonium salt, 0.8g of hyaluronic acid-RGD peptide, 1.2g of gelatin, and 1.0g of PVA to make 1%, 4%, 3%, and 5% concentration solutions respectively, and put them in a 250mL flask. Stir evenly, add 0.5g glycerin to the above solution, speed up the stirring rate, stir for 2 hours, and foam, quickly pour the mixture into a petri dish with a radius of 3cm, put it in a refrigerator at about -20°C, and pre-freeze for 24 hours , moved into a freeze-vacuum dryer, and vacuum-dried for 24-48 hours to obtain a composite sponge.

Embodiment 2

[0031] Weigh 0.4g of chitosan quaternary ammonium salt, 1.0g of hyaluronic acid-RGD peptide, 1.6g of gelatin, and 1.5g of PVA to make 2%, 5%, 4%, and 7.5% concentration solutions respectively, and put them in a 250mL flask. Stir evenly, add 1.0g glycerin to the above solution, speed up the stirring rate, stir for 4 hours, and foam, quickly pour the mixture into a petri dish with a radius of 3cm, put it in a refrigerator at about -20°C, and pre-freeze for 24 hours , moved into a freeze dryer, and vacuum-dried for 24-48 hours to obtain a composite sponge.

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Abstract

The invention relates to composite sponge and a preparation method of the composite sponge. The composite sponge is prepared from the following components in percentage by weight: 5%-15% of chitosan quaternary ammonium salt, 10%-23% of hyaluronic acid-RGD peptide, 25%-38% of gelatin, 15%-36% of PVA, and 5%-25% of glycerol. With the adoption of the technical scheme, the composite sponge and the preparation method have the beneficial technical effects that the antibacterial property of the novel chitosan sponge is improved, and the repairing for the surface of the wound is enhanced; the composite sponge containing the chitosan quaternary ammonium salt is simple in preparation method and low in cost, is safe and non-toxic, is obvious in antibacterial effect, can promote the cell growth, is beneficial for the repairing of the surface of the wound, is high in water absorption rate, and is suitable for industrial production.

Description

technical field [0001] The invention relates to a composite sponge and a preparation method thereof, belonging to the field of preparation of medical sponge dressings. Background technique [0002] The incidence of chronic difficult-to-heal wounds, such as ulcers and decubitus ulcers, has been increasing year by year with the aging of the population in recent years. For typical chronic refractory wounds, there are generally three characteristics: the wound is susceptible to infection; the wound has moderate to large amount of exudate; and the wound is painful. Although there are different types of dressings used in the treatment or nursing of chronic wounds clinically, they are all unsatisfactory and have some defects to varying degrees, such as weak anti-infection performance, drug allergy, poor ability to absorb exudate, and low wet strength. Poor, slow wound healing, etc. Chitosan, as the second largest natural polymer produced in the world, has the functions of hemosta...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61L15/46A61L15/44A61L15/42A61L15/32A61L15/28A61L15/24
CPCA61L15/24A61L15/28A61L15/325A61L15/425A61L15/44A61L15/46A61L2300/232A61L2300/412C08L5/08C08L89/06C08L29/04
Inventor 吕波洪慧宋豪源胡英
Owner WUHAN UNIV OF TECH
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