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Nanometer composite material having gold/tetra-sulfide hepta-copper core-shell structure and preparation method thereof

A technology of nanocomposite material and core-shell structure, which is applied in the field of gold/copper heptasulfide core-shell structure nanocomposite material and its preparation, which can solve the problems of high preparation cost, complex synthesis method and harsh conditions, and achieve particle dispersion Good, uniform particle size distribution, simple preparation method

Inactive Publication Date: 2013-08-21
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

At present, there are some studies on copper-sulfur compounds used as photothermal conversion agents in cancer laser hyperthermia at home and abroad, but the particle size of the obtained copper-sulfur compounds is relatively large, and the synthesis method is complicated, the conditions are harsh, and the preparation cost is high. Large limitations limit its further application in cancer clinical treatment research

Method used

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  • Nanometer composite material having gold/tetra-sulfide hepta-copper core-shell structure and preparation method thereof
  • Nanometer composite material having gold/tetra-sulfide hepta-copper core-shell structure and preparation method thereof
  • Nanometer composite material having gold/tetra-sulfide hepta-copper core-shell structure and preparation method thereof

Examples

Experimental program
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Embodiment 1

[0016] 1) Take 25 ml of chloroauric acid aqueous solution with a mass fraction of 0.01% and heat it to boiling under stirring, then add 0.5 ml of a 1.0% sodium citrate aqueous solution, react for 15 min, and cool to room temperature to obtain a gold nanoparticle sol solution.

[0017] 2) The gold sol solution (20 ml) prepared in step 1) was centrifuged at 6000 r / min for 20 min, the supernatant was removed, and 10 ml of deionized water was added to the gold nanoparticles in the lower layer to disperse to obtain Gold nanoparticles solution.

[0018] 3) Take 50 ml of copper nitrate solution with a concentration of 0.005 mol / L, add 0.5 g of polyvinylpyrrolidone to it to obtain a copper nitrate mixed solution, and add 2.5 ml of the gold nanoparticle solution prepared in step 2) while stirring at a constant temperature of 80 °C , and then added 0.01 ml of hydrazine hydrate with a mass fraction of 99%. After reacting for 2 min, the product was separated and washed three times with de...

Embodiment 2

[0022] 1) Take 25 ml of chloroauric acid aqueous solution with a mass fraction of 0.01% and heat it to boiling under stirring, then add 0.5 ml of a 1.0% sodium citrate aqueous solution, react for 40 min, and cool to room temperature to obtain a gold nanoparticle sol solution.

[0023] 2) The gold sol solution (20 ml) prepared in step 1) was centrifuged at a speed of 10,000 r / min for 10 min, the supernatant was removed, and 10 ml of deionized water was added to the gold nanoparticles in the lower layer for dispersion to obtain Gold nanoparticles solution.

[0024] 3) Take 50 ml of copper nitrate solution with a concentration of 0.05 mol / L, add 5 g of polyvinylpyrrolidone to it to obtain a copper nitrate mixed solution, and add 5 ml of the gold nanoparticle solution prepared in step 2) while stirring at a constant temperature of 80 °C , and then added 0.05 ml of hydrazine hydrate with a mass fraction of 99%. After 40 min of reaction, the product was separated and washed with dei...

Embodiment 3

[0027] 1) Take 50 ml of chloroauric acid aqueous solution with a mass fraction of 0.01% and heat it to boiling under stirring, then add 1 ml of 1.0% sodium citrate aqueous solution, react for 60 min, and cool to room temperature to obtain a gold nanoparticle sol solution.

[0028] 2) Centrifuge 50 ml of the gold sol solution prepared in step 1) at a speed of 12000 r / min for 5 min, remove the supernatant, and add 25 ml of deionized water to the lower layer of gold nanoparticles for dispersion to obtain gold nanoparticles particle solution.

[0029] 3) Take 50 ml of copper nitrate solution with a concentration of 0.1 mol / L, add 10 g of polyvinylpyrrolidone to it to obtain a copper nitrate mixed solution, and add 25 ml of the gold nanoparticle solution prepared in step 2) while stirring at a constant temperature of 20 °C , and then added 0.1 ml of hydrazine hydrate with a mass fraction of 99%. After reacting for 60 min, the product was separated and washed with deionized water th...

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Abstract

The invention discloses a nanometer composite material having a gold / tetra-sulfide hepta-copper core-shell structure and a preparation method of the nanometer composite material. The method comprises the following steps of: reducing chloroauric acid under a boiling condition to obtain a gold nano-particle sol solution; cleaning and concentrating the solution; dispersing into a cupric nitrate solution to ensure that the volume ratio of the gold nano-particle sol solution and the cupric nitrate solution is 0.05-0.5; reducing by using hydrazine hydrate to obtain gold / cuprous oxide core-shell structure particles; and finally, reacting gold / cuprous oxide particles with excessive amount of sodium sulfide in ethyl alcohol to obtain the nanometer composite material having the gold / tetra-sulfide hepta-copper core-shell structure. The preparation method of the composite material is simple and mild in condition; and in the preparation process, the particle dispersibility is good, the size is accurately controlled, the aim of medicinal-thermal co-therapy (medicine chemotherapy and laser-induced thermotherapy) against cancers is fulfilled, and the significance to the development of a cancer treatment method is realized.

Description

Technical field [0001] The present invention involves a gold / tadpan sulfurized seven -copper nuclear shell structure nano -composite materials and its preparation methods.It belongs to the technology field of gold and sulfide composite materials. Background technique [0002] Cancer, as a global public health issue, greatly threatens human health and has increasingly become the first killer that leads to human death.Therefore, the treatment of cancer has always been a huge challenge and key research direction in the medical field.At present, traditional treatments for cancer are mainly chemical treatment, radiation therapy, surgical treatment, and hormone immunotherapy. Although these methods have certain effects on the treatment of cancer, there are also deaths that can easily cause normal cells in the human body, destroy human immune immunityThe shortcomings of the system and the recurrence of cancer.Wide research and clinical data show that laser therapy can well overcome the ...

Claims

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Application Information

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IPC IPC(8): A61K41/00A61K47/02A61P35/00
Inventor 何芳刘贵高黄远李立军陈利霞李凤娇
Owner TIANJIN UNIV
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