Preparation method of ginkgo leaf essence

A technology of Ginkgo biloba extract and Ginkgo leaf, which is applied in the field of preparation of Ginkgo biloba extract refined product Ginkgo biloba extract, can solve the problems of many inorganic chemical media, high cost, complex process, etc., to improve the stability of properties and increase the content And the effect of easy control of proportion and process

Active Publication Date: 2015-04-22
中意九州生物科技有限公司
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  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In this method, many organic and inorganic chemical media are used, the process is complicated, the cost is high, and it is easy to cause residue, which affects the quality of the product.
At present, the production technology of Ginkgo biloba extract in China is mainly extracted by water or alcohol solvent, and then adsorbed by macroporous resin (Chinese Patent Application No. 94114835.1), but its acquisition rate is low, and the content of the obtained extract is also low. high

Method used

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  • Preparation method of ginkgo leaf essence

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Experimental program
Comparison scheme
Effect test

Embodiment 1

[0026] Get 100kg of Ginkgo biloba leaves, use 12, 10, and 10 times the amount of 40% ethanol (referring to the ratio of raw material weight to solution volume, the same as in the following example). Immersion and stirring at 80°C for three times, 2 hours each time, release the extract, combine and concentrate to a small volume, add 5 times the amount of purified water to dilute, and add 5 times the amount of purified water after crude separation of the medicinal solution at 0°C or - Settling at 1°C. The supernatant was passed through styrene macroporous adsorption resin (AB-8), washed with 2 times the resin volume of water, eluted with 20% ethanol, and then eluted with 70% ethanol to collect the eluate. The resin can be reused after regeneration. The eluate was concentrated under reduced pressure, then dried under reduced pressure, and the temperature was controlled to be less than or equal to 75°C to obtain 2.4 kg of Ginkgo biloba extract containing 26.5% of ginkgo flavonol ...

Embodiment 2

[0028] Take 200kg of Ginkgo biloba leaves and pulverize it into coarse powder, extract 10, 6, and 5 times the amount of 75% ethanol at 70 ° C for three times, each time for 3 hours, release the extract, combine and concentrate to a small volume, and add 8 times the amount of purified water. Diluted, after crude separation of the medicinal solution, the purified water was added to make the volume to 1600L, and the solution was allowed to settle at a temperature of 20°C. The supernatant was passed through a styrene macroporous adsorption resin column (DM-130), washed with 2 times the resin volume of purified water, eluted with 30% ethanol, and then eluted with 95% ethanol to collect the eluate. The resin can be reused after regeneration. The eluate is concentrated under reduced pressure at a temperature of less than 75°C, and then spray-dried to obtain 4.6kg of Ginkgo biloba extract containing flavonol glycosides ≥ 28%, ginkgo terpene lactones ≥ 9%, and ginkgo lactones up to 4.5...

Embodiment 3

[0030] Take 200kg of Ginkgo biloba leaves and pulverize them into coarse powder, extract 9, 7, and 5 times the amount of 85% ethanol at 70 °C for three times, each time for 3 hours, release the extract, combine and concentrate to a relative density of 1.20 at 70 °C, add 8 times After the crude separation of the medicinal liquid, the purified water was added to dilute to 1600L, and the liquid was allowed to settle at a temperature of 20°C. The supernatant was passed through a styrene macroporous adsorption resin column (DM-130), washed with 2 times the resin volume of purified water, eluted with 25% ethanol, and then eluted with 90% ethanol, and the eluate was collected. The resin can be reused after regeneration. Eluent with CO 2 Supercritical fluid drying, the conditions are: drying temperature 40 ℃, pressure 15MPa, CO 2 The flow rate is 20kg / h, and 5.2kg of Ginkgo biloba extract containing flavonol glycosides ≥28%, ginkgo terpene lactones ≥10%, of which ginkgo lactones are...

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Abstract

The invention relates to a preparation method of ginkgo leaf essence. The preparation method comprises the following steps of: extracting ginkgo leaves by hydrous ethanol for a plurality of times, concentrating an extracting solution, recovering a solvent, diluting the concentrated solution by water or purified water, cooling the diluted solution at the temperature below 20 DEG C, precipitating, taking supernate, absorbing the supernate by a macroporous resin column, carrying out elution by an alcoholic solution for twice, and drying the eluant to obtain the ginkgo leaf essence. In the preparation method, the used medium does not contain or contains less harmful substance residues; the method is easy in technology control and high in extraction yield; and the product is high in content of active ingredients and stable in quality.

Description

technical field [0001] The invention relates to an extraction technology of natural plant medicinal components, in particular to a preparation method of ginkgo biloba extract, a refined product of ginkgo biloba extract. Background technique [0002] Ginkgo biloba is one of the oldest tree species in the world and is known as a "living fossil". Ginkgo biloba leaves are the leaves of Ginkgo biloba. Ginkgo biloba leaf is sweet, bitter and astringent in nature, beneficial to the heart and lungs, dampness and diarrhea. "Chinese Medicine Chronicles" records that it can "absorb lung qi, relieve asthma and cough, and stop turbidity". According to modern pharmacological research, Ginkgo biloba has a wide range of effects on the human body, such as improving cardiovascular and peripheral vascular circulation functions, improving myocardial ischemia, promoting memory and improving brain function. In addition, Ginkgo biloba extract (GBE) has a very strong antioxidant effect, which can...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/16A61K127/00
Inventor 崔海影
Owner 中意九州生物科技有限公司
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