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Production process for extraction of chlorogenic acid from green coffee bean

A green coffee bean and production process technology, which is applied in the preparation of carboxylic acid esters, the preparation of organic compounds, organic chemistry, etc., can solve the problems that the content of chlorogenic acid is not fully proposed, the content of chlorogenic acid is not high, and the process is complicated. The effect of improving the yield and its purity, saving the cost of raw materials, and simplifying the process

Active Publication Date: 2013-08-07
南京宏冠生物科技有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] However, the process for producing chlorogenic acid in the prior art is not only complicated, but the content has not been fully proposed mainly through repeated alcohol extraction, and the content of chlorogenic acid proposed is not high in addition. Chlorogenic acid includes total acid and Monoacids, usually companies can only extract up to 50% of total acids, and monoacids are around 20%

Method used

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Examples

Experimental program
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Effect test

Embodiment 1

[0016] The invention discloses a production process for extracting chlorogenic acid from green coffee beans. The green coffee beans are used as raw materials, and the chlorogenic acid is obtained through crushing, extraction, concentration, centrifugal ultrafiltration, resin separation and elution, and refining.

[0017] (1) The crushing process is as follows: 2000Kg green coffee beans are crushed to 10mm particles by superradiation wave pretreatment.

[0018] (2) The extraction process is as follows: add 80% ethanol three times according to the mass multiple of green coffee beans, 4 times, 3 times, and 3 times, and extract three times from the crushed green coffee bean particles, that is, add 80% ethanol three times The ethanol is 8000Kg, 6000Kg, 6000Kg respectively, and then the extracts are collected three times respectively. The extraction time is 1.5h, 1.5h, 1.5h respectively, and the extraction temperature is 90°C. The first extract is concentrated to obtain 27.25% The t...

Embodiment 2

[0024] The invention discloses a production process for extracting chlorogenic acid from green coffee beans. The green coffee beans are used as raw materials, and the chlorogenic acid is obtained through crushing, extraction, concentration, centrifugal ultrafiltration, resin separation and elution, and refining.

[0025] (1) The crushing process is as follows: 2000Kg green coffee beans are crushed to 10mm particles by superradiation wave pretreatment.

[0026] (2) The extraction process is as follows: add 80% ethanol three times according to the mass multiple of green coffee beans, 3 times, and 2 times, and extract three times from the crushed green coffee bean particles, that is, add 80% ethanol three times The ethanol was 10000Kg, 6000Kg and 4000Kg respectively, and then the extracts were collected three times respectively. The extraction time was 1.5h, 1.5h and 1.5h respectively, and the extraction temperatures were 85°C, 90°C, and 95°C respectively. Concentrate to obtain a...

Embodiment 3

[0032] The invention discloses a production process for extracting chlorogenic acid from green coffee beans. The green coffee beans are used as raw materials, and the chlorogenic acid is obtained through crushing, extraction, concentration, centrifugal ultrafiltration, resin separation and elution, and refining.

[0033] (1) The crushing process is as follows: 2000Kg green coffee beans are crushed to 10mm particles by superradiation wave pretreatment.

[0034] (2) The extraction process is as follows: add 80% ethanol three times according to the mass multiple of green coffee beans, 4 times, 2 times, and extract three times from the crushed green coffee bean particles, that is, add 80% ethanol three times The ethanol was 8000Kg, 8000Kg, 4000Kg respectively, and then the extracts were collected three times, the extraction time was 1.5h, 1.5h, 1.5h respectively, and the extraction temperatures were 90°C, 90°C, 88°C respectively. Concentrate to obtain a total of 362kg of total chl...

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Abstract

The invention brings forward a production process for extraction of chlorogenic acid from a green coffee bean. According to the production process, the green coffee bean is used as a raw material, and crushing, extraction, condensation, centrifugal ultrafiltration, resin separation, elution and refining are carried out so as to obtain chlorogenic acid. Compared with the prior art, the invention has the following beneficial effects: since supersonic waves are used for pretreatment, ultrafiltration technology is used for removing macro-molecules and the resin D-140 is used to adsorb chlorogenic acid or adjust a pH value, chlorogenic acid is separated from an organic layer in an aqueous layer, the yield rate and the purity of chlorogenic acid are substantially improved, chlorogenic acid contained in the green coffee bean can be effectively and fully extracted, 70% of total chlorogenic acid can be extracted, 60% of single chlorogenic acid can be extracted, cost for the raw material is saved, technology is improved, no harmful solvent is used, and the production process is simple and easy and is suitable for industrial production.

Description

technical field [0001] The invention relates to a production process for extracting chlorogenic acid from green coffee beans. Background technique [0002] Chlorogenic acid, also known as chlorogenic acid, coffee tannin, 3-caffeoyl quinic acid Cyclohexanecarboxylic acid, (1S,3R,4R,5R)-3-[[3-(3,4-dihydroxyphenyl)-1 -Oxo-2-propenyl]oxy]-1,4,5-trihydroxycyclohexanecarboxylic acid, research data show that chlorogenic acid is almost non-toxic, and the LD50 of young rats orally is greater than 1g / kg, and the intraperitoneal injection is greater than 0.25 g / kg. It has a wide range of biological activities. Modern scientific research on the biological activities of chlorogenic acid has penetrated into many fields such as food, health care, medicine and daily chemical industry. Chlorogenic acid is an important biologically active substance, which has the functions of antibacterial, antiviral, increasing white blood cells, protecting liver and gallbladder, antitumor, lowering blood ...

Claims

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Application Information

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IPC IPC(8): C07C69/732C07C67/56
Inventor 王恕
Owner 南京宏冠生物科技有限公司
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