A kind of preparation method of (r)-3,5-bis(trifluoromethyl)phenethyl alcohol

A technology of trifluoromethyl and phenylethyl alcohol, applied in the field of preparation of chiral pharmaceutical intermediates by asymmetric catalytic hydrogenation, can solve the problems of high price, impact on industrial production, and low production efficiency of biological methods

Active Publication Date: 2016-03-16
GUANGXI XINJING TECH +1
View PDF4 Cites 0 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Grasa etc. (JournalofOrganometallicChemistry, 2006,691:2332-2334.) at room temperature and under the effect of [(diphosphine) ruthenium dichloride (diamine compound)] novel catalyst, with isopropanol as solvent, the conversion rate 95% (R)-3,5-bis(trifluoromethyl)phenylethyl alcohol Gelo-Puiic etc. (Tetra-hedronAsymmetry, 2006,17:2000-2005.) adopts Lactobacillus kefir (Lactobacilluskefir) and Aspergillus niger (Aspergillusniger), reduction of 3,5-bis(trifluoromethyl)acetophenone, obtains (R)-3,5-bis(trifluoromethyl)phenethyl alcohol product with ee value as high as 99%, the largest of this method The disadvantage is that a large amount of coenzyme needs to be added, and the initial concentration of the reactant is too low, which seriously affects industrial production
[0007] Among these methods reported in the literature, both chemical synthesis and biosynthesis use 3,5-bis(trifluoromethyl)acetophenone as a raw material, and the separation of chemical catalysts is difficult and expensive
However, the production efficiency of the biological method is relatively low, and the amount of coenzyme added is large
Industrial production costs are relatively high

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • A kind of preparation method of (r)-3,5-bis(trifluoromethyl)phenethyl alcohol
  • A kind of preparation method of (r)-3,5-bis(trifluoromethyl)phenethyl alcohol

Examples

Experimental program
Comparison scheme
Effect test

example 1

[0031] Complexation steps:

[0032] 0.0082g catalyst [RuCl 2 (C 10 h 14 ) 2 ] 2 and the chiral phosphine ligand (S,S)-C 6 P 2 (NH) 2 Put it into a (catalyst: ligand=1:2) 100mL round bottom flask, add 50mL of tetrahydrofuran, and stir magnetically at 0°C for 10min to fully complex the catalyst and the ligand.

[0033] Reaction steps:

[0034] In the 2500mL reactor, add 400mL of tetrahydrofuran (organic solvent: substrate=20:1), and then add 20mL of substrate 3,5-bis(trifluoromethyl)acetophenone and 0.82gKOH (base:catalyst=100:1 ) into the reaction kettle, and then add 50 mL of the above-mentioned complexed catalyst and ligand mixed solution, and replace the reaction kettle with hydrogen for 3 times to ensure that the reaction is carried out under anaerobic conditions. Turn on the stirring, set the stirring rate to 600r / min, and the hydrogen pressure to 2MPa. Afterwards, the temperature was raised to 100°C and kept at a constant temperature, and the reaction was carrie...

example 2

[0039] Complexation steps:

[0040] 0.0082g catalyst Ir[(COD)Cl] 2 and the chiral ligand (S,S)-C 6 P 2 (NH) 2 (catalyst: ligand = 1: 1) was put into a 100mL round-bottomed flask, 50mL of toluene was added, and magnetically stirred at 10°C under normal pressure for 20min to fully dissolve and complex the catalyst and the ligand;

[0041] Reaction steps:

[0042] In 2500mL reactor, add toluene 2000mL (organic solvent: substrate=100: 1), behind the 20mL substrate 3,5-bis(trifluoromethyl) acetophenone and 0.082gKOH (base: catalyst=10: 1 ) into the reaction kettle, and then add 50 mL of the above-mentioned complexed catalyst and ligand mixed solution, and replace the reaction kettle with hydrogen for 3 times to ensure that the reaction is carried out under anaerobic conditions. Stirring was started, the stirring rate was set to 600r / min, and the hydrogen pressure was 2.5MPa. Afterwards, the temperature was raised to 45°C and kept at a constant temperature, and the reaction wa...

example 3

[0047] Complexation steps:

[0048] 0.0082g catalyst Ir[(COD)Cl] 2 Put the chiral ligand BINAP (catalyst: ligand = 1: 1.2) into a 100mL round bottom flask, add 50mL of absolute ethanol, and stir magnetically at 20°C for 30min to fully dissolve and complex the catalyst and the ligand;

[0049] Reaction steps:

[0050] In 2500mL reactor, add dehydrated alcohol 600mL (organic solvent: substrate=30: 1), behind 20mL substrate 3,5-bis(trifluoromethyl) acetophenone and 0.164gNaOH (base: catalyst=20 : 1) add in the reactor, then add 50mL of the catalyst and ligand mixed solution that the above-mentioned complexation is completed, replace 3 times with hydrogen in the reactor, to guarantee that the reaction is carried out under anaerobic conditions. Turn on the stirring, set the stirring rate to 600r / min, and the hydrogen pressure to 3MPa. Afterwards, the temperature was raised to 50°C and kept at a constant temperature, and the reaction was carried out for 6h.

[0051] Separation s...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

PropertyMeasurementUnit
boiling pointaaaaaaaaaa
flash pointaaaaaaaaaa
Login to view more

Abstract

The present invention provides a method for preparing (R)-3,5-bis(trifluoromethyl)benzene-ethanol by using 3,5-bis(trifluoromethyl)acetophenone as a raw material, through asymmetric-hydrogenation catalytic reduction. The method of the invention belongs to the technical field of asymmetric catalytic hydrogenation synthesis of chiral pharmaceutical intermediates. In the method, [RuCl2(C10H14)2]2 or Ir[(COD)Cl]2 is used as a catalyst, and BINAP or (S, S)-C6P2 (NH) 2 is used as a chiral phosphine ligand to form a complex catalyst, in an oxygen-free sealed high-pressure hydrogenation reaction system, the substrate 3,5-bis(trifluoromethyl)acetophenone is catalyzed to prepare (R)-3,5-bis(trifluoromethyl)benzene-ethanol.

Description

technical field [0001] The invention relates to a method for preparing a chiral pharmaceutical intermediate by asymmetric catalytic hydrogenation, specifically, (R)-3 is prepared by asymmetric hydrogenation catalytic reduction of 3,5-bis(trifluoromethyl)acetophenone as a raw material , the method of 5-bis(trifluoromethyl)phenethyl alcohol. Background technique [0002] Chiral hydroxy alcohols are an important class of pharmaceutical and chemical intermediates, widely used in pharmaceuticals, food, spices and pesticides and other fields. The chemical formula of (R)-3,5-bis(trifluoromethyl)phenethyl alcohol is C 9 h 8 f 6 O, English name: (R)-3,5-bis(trifluoromethyl)benzene-ethanol, its structural formula is as follows: [0003] [0004] Physical and chemical properties: CAS: 127852-28-2; Molecular weight: 258.16; Density: 1.376g / mL; Boiling point: 175.8°C; Flash point: 60.1°C. [0005] (R)-3,5-bis(trifluoromethyl)phenethyl alcohol is a key intermediate in the synthesi...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
Patent Type & Authority Patents(China)
IPC IPC(8): C07C33/46C07C29/143
Inventor 蒲国荣孙果宋韦志明黄科润黄平穆允玲袁芳爱周龙昌向忠权
Owner GUANGXI XINJING TECH
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap