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Benorilate vitamin B1 particle for children and preparation process thereof

A technology of benoxylate and granules, which is applied in the field of medicine, can solve the problems of increasing the burden on children's liver and kidneys, the effect of the medicine is not long enough, and serious side effects, etc., and achieves the effect that fever is not easy to repeat, the preparation process is simple and feasible, and the toxic and side effects are small.

Inactive Publication Date: 2014-09-17
XIANGYU PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, it has the disadvantages of general western medicine, such as insufficient long-lasting drug effect, easy recurrence of fever, etc., requiring multiple doses of medicine, which easily increases the burden on children's liver and kidneys, and brings relatively large side effects.

Method used

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  • Benorilate vitamin B1 particle for children and preparation process thereof
  • Benorilate vitamin B1 particle for children and preparation process thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0016] A kind of beinolate vitamin B1 granules for children, which is prepared from the following ingredients: 0.3kg beinolate, vitamin B1 1 3g, 2.69kg of sucrose, 3g of essence and 0.25g of lemon yellow.

[0017] A preparation process of children's benolate vitamin B1 granules, which comprises the steps of:

[0018] (1) Sieving: Benoate and vitamin B1 are passed through a 100-mesh sieve, and sucrose is crushed through a 100-mesh sieve for subsequent use;

[0019] (2) Mixing: Weigh 0.3kg of Benoate, vitamin B 1 3g and 2.69kg of sucrose, first add Benoate and vitamin B 1 Mix well, then add sucrose and mix well;

[0020] (3) making soft material: 250ml of 30% ethanol solution that will be added with 0.25g tartrazine is added in the above-mentioned mixed powder, making soft material;

[0021] (4) Granulation: pass the soft material through a 20-mesh sieve to make wet granules;

[0022] (5) Drying: dry the wet granules at 60°C for 5 hours;

[0023] (6) granulation: pass the ...

Embodiment 2

[0027] A kind of beinolate vitamin B1 granules for children, which is prepared from the following ingredients: 0.3kg beinolate, vitamin B1 1 3g, 2.69kg of sucrose, 3g of essence, 0.25g of lemon yellow, 200g of Gongluomu, 180g of Chuanxiong, 160g of turmeric, 150g of Eucommia, 120g of safflower, 120g of Achyranthes bidentata, 100g of Bupleurum, 80g of Coptis chinensis, 80g of pangolin , Angelica dahurica 60g, ginseng 50g, Trichosanthes 30g.

[0028] A preparation process of children's benolate vitamin B1 granules, which comprises the steps of:

[0029] (1) Sieving: Benoate and vitamin B1 are passed through a 100-mesh sieve, and sucrose is crushed through a 100-mesh sieve for subsequent use;

[0030] (2) Mixing: Take 200g of Gongluomu, 180g of Chuanxiong, 160g of Curcuma, 150g of Eucommia, 120g of Safflower, 120g of Achyranthes, 100g of Bupleurum, 80g of Coptidis, 80g of Pangolin, 60g of Angelica dahurica, 50g of Ginseng, melon 30 g of betel, mixed, added 10 times the weight o...

Embodiment 3

[0039] The pharmacological experiment of the medicine that embodiment 1 and embodiment 2 prepare

[0040] 1. Toxicity test:

[0041] This experiment adopts healthy SD rats, and the drug dose gradient prepared by oral administration embodiment 1 and embodiment 2 is 0.01g / kg and 0.1g / kg, and it is administered continuously for 30 days. Within 1 week after taking the drug, there was no significant effect on animal growth status, activity and diet, hematology, blood biochemistry, organ tissue structure, and urine routine, which indicated that the clinical drug was safe and reliable.

[0042] 2. Analgesic experiment:

[0043] Effect on the writhing reaction induced by acetic acid in BALB / c mice: 60 BALB / c mice, half male and half male, with an average body weight of 28.3g, were randomly divided into 3 groups, which were respectively normal saline group, embodiment 1 drug group, Embodiment 2 medicine group; Administer once every day, dose is 0.01g / kg (experimental group gives medi...

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Abstract

The invention belongs to the field of medical technology and discloses a benorilate vitamin B1 particle for children. The benorilate vitamin B1 particle for children is prepared from 0.3kg of benorilate, 3g of vitamin B1, 2.69g of sucrose, 3g of essence and 0.25g of tartrazine. The invention also discloses a preparation method of the benorilate vitamin B1 particle for children. According to the benorilate vitamin B1 particle for children, a good curative effect is brought to cold fever, the cold fever is not easy to relapse, less toxic and side effects are caused and the preparation process is simple and feasible.

Description

technical field [0001] The invention belongs to the technical field of medicines, and in particular relates to children's benoxylate vitamin B1 granules and a preparation process thereof. Background technique [0002] Fever is a common disease in young children, and its etiology is mostly caused by infection of pathogenic microorganisms. The pathogenic microorganisms that cause fever in young children mainly include bacteria, viruses, mycoplasma, and chlamydia. In the prior art, the research on the treatment method of exogenous fever in children is the most, mainly including (1) physical cooling, such as warm water or alcohol scrub bath, ice pack cooling, saline enema, etc.; Naijin or intramuscular injection, intravenous infusion of dexamethasone and other drugs, while taking antibiotics to treat infection; (3) Chinese medicine therapy: such as oral Chinese medicine preparations, external application of Chinese medicine, etc. However, there are many defects in the above-men...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K31/621A61K36/9066A61K9/16A61P29/00A61P11/00A61K31/51
Inventor 林凡友
Owner XIANGYU PHARMA
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