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Method for preparing fumaric acid through cis-trans isomerization of maleic acid

A technology of cis-trans isomerization and maleic acid, applied in the field of preparation of fumaric acid, can solve the problems of excessive waste liquid, large amount of catalyst, corrosion of catalyst to equipment, etc., and achieves high catalytic efficiency, low production cost, and product high yield effect

Inactive Publication Date: 2013-07-17
XIANGTAN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

In these methods, there are problems such as large amount of catalyst used, excessive waste liquid in the production process, and catalyst corrosion to equipment.

Method used

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  • Method for preparing fumaric acid through cis-trans isomerization of maleic acid
  • Method for preparing fumaric acid through cis-trans isomerization of maleic acid
  • Method for preparing fumaric acid through cis-trans isomerization of maleic acid

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0015] 2 mg of metalloporphyrins of formula (I), R 1 is cyclodextrin, R 2 for CH 3 , R 3 is H, M is Mn, X=C1, add 2g of maleic acid and 40ml of DMF, continuously feed air, the reaction pressure is 0.1Mpa, the flow rate is 0.05L / min, the reactant is stirred at 100°C for 5 hours, the product The yield of fumaric acid was 85%.

Embodiment 2

[0017] 3 mg of a metalloporphyrin of formula (I), R 1 , R 2 for Cl, R 3 is H, M is Mn, X is Br, add 1.6g maleic acid and 35ml DMF, continuously feed oxygen, the reaction pressure is 1.2Mpa, and the flow rate is 0.03L / min. The reactant was stirred at 120° C. for 8 hours, and the yield of the reaction product fumaric acid was 94%.

Embodiment 3

[0019] Chitin is immobilized with 3 mg metalloporphyrins of structural formula (I), R 1 for NO 2 , R 2 , R 3 Cl is Cl, M is Co, X is Br, add 1.5g maleic acid and 40ml xylene, continuously feed oxygen-deficient air containing 15% (v / v) oxygen, the reaction pressure is 0.2Mpa, and the flow rate is 0.03L / min. The reactant was stirred at 100° C. for 6 hours, and the yield of the reaction product fumaric acid was 88%.

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Abstract

The invention discloses a method for preparing fumaric acid through the cis-trans isomerization of maleic acid. The method comprises the following steps of: taking maleic acid as a raw material in the presence of air or oxygen according to the mass ratio of raw material to the solvent being 1:1-1:80, wherein the solvent contains N,N-dimethylformamide (DMF), dimethyl sulfoxide (DMSO), ethyl acetate, benzene, methylbenzene or nitrobenzene; controlling conditions that the reaction pressure is under 0.1-1.2Mpa and the temperature is 50-150 DEG C, reacting for 1-12 hours by taking monometallic porphyrin in formula (I) or mu-oxo bimetal porphyrin in formula (II) or immobilized metal porphyrin formed as catalysts, wherein the concentration of the catalysts is 5-160PPM; and performing isomerization of maleic acid to obtain the product fumaric acid. The method has the following technical effects of being small in catalyst usage amount, high in catalytic efficiency, free from corrosion action to the equipment, high in conversion rate, high in product yield, and low in production cost.

Description

technical field [0001] The invention relates to a preparation method of fumaric acid. Background technique [0002] Fumaric acid, also known as fumaric acid, and maleic acid (maleic acid) are opposite isomers of cis-trans configuration, is an important organic chemical raw material and fine chemicals, widely It is used in many fields such as medicine, food, chemical industry, feed and so on. For a long time, scholars at home and abroad have carried out in-depth and meticulous research on the preparation of fumaric acid, and found many methods, the most effective of which is the catalytic conversion of maleic acid, but the current catalytic system has a large amount of catalyst and environmental pollution. , The problem of equipment corrosion. [0003] The traditional production method of fumaric acid mainly uses bromine, bromide, sulfuric acid, hydrochloric acid, thiosulfite, etc. as catalysts. The disadvantage of these methods is that the amount of catalyst and co-cataly...

Claims

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Application Information

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IPC IPC(8): C07C57/15C07C51/353B01J31/22
Inventor 李勇飞周凯刘跃进吴志民谈瑛杨彦松王欢
Owner XIANGTAN UNIV
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