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Dragon blood spraying film agent applied to superficial wound and preparation technology thereof

A preparation process and spray film technology, applied in the medical field, can solve the problems of waste of medicinal materials, inconvenient carrying, inconvenient use, etc.

Inactive Publication Date: 2013-07-10
中国医学科学院药用植物研究所云南分所
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is clinically used for various diseases such as cardiovascular diseases, bruises, burns, bedsores, hemorrhoids, cervical erosion, uterine fibroids, colitis, etc., especially for traumatic bleeding and gastrointestinal bleeding, and has a "holy medicine for hemostasis" It is said that with the increase of market demand, the medicinal resources of dragon's blood are becoming more and more scarce, and the traditional application of dragon's blood medicinal materials directly applied to the wound shows that it is not only inconvenient to use, but also has low bioavailability, resulting in a large amount of waste of medicinal materials. The invention discloses a dragon's blood patch (CN 102872303 A), which is limited by the dosage form and is inconvenient to carry. Therefore, an efficient and convenient dragon's blood preparation is invented, which can solve the increasingly severe resource crisis and bring new benefits to the use. come very convenient

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0011] Example 1 Preparation of dragon's blood jerky spray film

[0012] 1. Weigh 1.5g of dragon's blood and 3g of borneol, dissolve in 50mL of absolute ethanol, dissolve completely, and obtain solution A.

[0013] 2. Weigh 3g of polyvinylpyrrolidone, 2g of polyethylene glycol 2000, 1g of methylcellulose, 1g of ethylcellulose, and 1.5g of polyvinyl alcohol, dissolve them in 40mL of distilled water and stir, swell for 24 hours, and dissolve them all to obtain Solution B.

[0014] 3. Add solution A to solution B, stir evenly, and add 0.2g glycerin for reconciliation without precipitation.

[0015] 4. Put the solution obtained in step 3 into a spray bottle. Under the pressure of the nozzle, the liquid in the bottle can be sprayed into a mist, and the drug can quickly form a film when attached to the skin surface.

Embodiment 2

[0016] Example 2 Preparation of dragon's blood jerky spray film

[0017] 1. Weigh 2g of dragon's blood and 4g of borneol, dissolve in 50mL of absolute ethanol, dissolve completely, and form solution A.

[0018] 2. Weigh 6g of polyvinylpyrrolidone, 3g of polyethylene glycol 2000, 2g of methylcellulose, 2g of ethylcellulose, and 3g of polyvinyl alcohol, dissolve them in 70mL of distilled water and stir, swell for 24 hours, and dissolve them all to obtain a solution b.

[0019] 3. Add solution A to solution B, stir evenly, and add 0.5g glycerin for reconciliation without precipitation.

[0020] 4. Put the solution obtained in step 3 into a spray bottle. Under the pressure of the nozzle, the liquid in the bottle can be sprayed into a mist, and the drug can quickly form a film when attached to the skin surface.

Embodiment 3

[0021] Example 3 Preparation of dragon's blood jerky spray film

[0022] 1. Weigh 1g of dragon's blood and 2g of borneol, dissolve in 40mL of absolute ethanol, dissolve completely, and form solution A.

[0023] 2. Weigh 2g of polyvinylpyrrolidone, 1g of polyethylene glycol 2000, 0.5g of methylcellulose, 0.5g of ethylcellulose, and 0.5g of polyvinyl alcohol, dissolve them in 50mL of distilled water and stir, and swell for 24 hours to make them all dissolve , to obtain solution B.

[0024] 3. Add solution A to solution B, stir evenly, and add 0.01g glycerin for reconciliation without precipitation.

[0025] 4. Put the solution obtained in step 3 into a spray bottle. Under the pressure of the nozzle, the liquid in the bottle can be sprayed into a mist, and the drug can quickly form a film when attached to the skin surface.

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PUM

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Abstract

The invention discloses a dragon blood spraying film agent applied to a superficial wound and a preparation technology thereof. The dragon blood spraying film agent is characterized by comprising the following components by weight percent of 1-3% of dragon blood, 2-4% of borneol, 2-6% of polyvinylpyrrolidone, 1-3% of polyethylene glycol 2000, 0.5-2% of methylcellulose, 0.5-2% of ethyecellulose, 0.5-3% of polyving alcohol, 0.01-0.5% of glycerol, 40-70% of ethanol and the balance of distilled water. The preparation technology comprises the steps of dissolving the dragon blood and the borneol drug into solution A by the ethanol with the weight percent; evenly agitating the polyvinylpyrrolidone, the polyethylene glycol 2000, the methylcellulose, the ethyecellulose and the polyving alcohol into the distilled water to swell for 24 hours to prepare solution B, mixing the solution A with the solution B, blending the glycerol, and charging into a pressure spray bottle, and finally obtaining the dragon blood spraying film agent. The spraying film agent sprays the solution containing a drug into fog to be attached to the skin surface to quickly form a film under the effects of bottle pressure and the nozzle pressure. The spray film agent has the effects of stopping bleeding, inhibiting bacterium, healing sore and relieving pain, and is especially suitable for the symptoms such as small-area burns and scalds, scratch, bruise and unhealing score.

Description

technical field [0001] The invention belongs to the field of medical technology, and particularly relates to a spray film of dragon's blood for treating superficial wounds and a preparation process thereof. It is a spray film agent for hemostasis in trauma, astringent sores, and infection prevention. Background technique [0002] Dracaena cochinchinensis (Lour.) S.C.Chen is a resin extracted from the lipid-containing xylem of Dracaena cochinchinensis (Lour.) S.C.Chen. It is mainly produced in southern Yunnan and Southern Guangxi. It has the effects of promoting blood circulation and removing blood stasis, reducing swelling and relieving pain, astringent and hemostasis, softening hard masses and resolving stagnation, promoting granulation and suppressing sores. It is clinically used for various diseases such as cardiovascular diseases, bruises, burns, bedsores, hemorrhoids, cervical erosion, uterine fibroids, colitis, etc., especially for traumatic bleeding and gastrointest...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/896A61K9/12A61P17/02A61P31/02A61P7/04A61K31/045A61K9/70
Inventor 陈曦李光李宜航路娟李学兰马小军
Owner 中国医学科学院药用植物研究所云南分所
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