Zengyetang formula granules and its preparation method, application and detection method
A technology of formula particles and detection methods, which is applied in pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc., can solve the problems of changes in clinical efficacy, changes in pharmacological effects, and neglect of the integrity of traditional Chinese medicine decoctions.
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Embodiment 1
[0085] The preparation of embodiment 1 Zengyetang formula granules
[0086] Take 149.9g of Radix Scrophulariae, 120.1g of Ophiopogon japonicus, and 119.9g of Rehmannia glutinosa, soak in water for 0.5h, decoct twice for 2 hours each time, filter the decoction, combine the two filtrates, and concentrate to a relative density of 1.05-1.10 (60°C) clear paste; take clear paste, spray dry (spray drying parameters are air inlet temperature 154°C, air outlet temperature 95°C, pump speed 25%) to obtain dry extract powder, add appropriate amount of water, granulate , sieving, subpackaging, and testing to obtain 210 g of Zengyetang formula granules. Process flow chart see figure 1 .
[0087] The results of dry extract powder are shown in Table 2.
[0088] Table 2 Extract result table
[0089] Extract character Extraction amount (g) Extraction rate (%) dry extract Light yellow; slightly fragrant, bitter, astringent 208.0 53.33
[0090] Get Zengyetang f...
Embodiment 2
[0095] The preparation of embodiment 2 Zengyetang formula granules
[0096] Take 720g of Radix Scrophulariae, 576g of Ophiopogon japonicus, and 576g of Rehmannia glutinosa, soak in water for 0.25h, decoct twice for 1.5 hours each time, filter the decoction, combine the two filtrates, and concentrate to a relative density of 1.05-1.10 (60°C ) clear paste, spray-dried to obtain powder, add appropriate amount of water, granulate and sieve to obtain Zengyetang formula granules 1000g.
Embodiment 3
[0097] The preparation of embodiment 3 Zengyetang formula granules
[0098] Take 720g of Radix Scrophulariae, 576g of Ophiopogon japonicus, and 576g of Rehmannia glutinosa, soak in water for 1 hour, decoct twice for 2.5 hours each time, filter the decoction, combine the two filtrates, and concentrate to a relative density of 1.05-1.10 (60°C) The clear paste was spray-dried to obtain a powder, which was added with an appropriate amount of water, granulated and sieved to obtain 1010 g of Zengyetang formula granules.
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