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Artificial lens with drug sustained release micro-capsules inlaid on loop and manufacturing method thereof

A technology of intraocular lens and manufacturing method, which is applied in the direction of medical devices, intraocular lenses, prostheses, etc., can solve the problems of inhibition and uncertainty of inhibition degree, poor stability of drug coating, and reduce the incidence of inflammation, etc., to achieve improved Effects of long-term vision, targeted inhibition of lens epithelial cells, and reduction of inflammatory infection

Active Publication Date: 2013-06-19
SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Chinese patent CN1701769A "Surface phospholipid-modified soft intraocular lens and its manufacturing method" is to modify the front surface of the hydrophobic intraocular lens contacting the anterior chamber to be hydrophilic through phospholipid modification, thereby reducing bacteria and inflammatory cells in the intraocular lens In order to reduce the incidence of inflammation; the Chinese patent CN1608601A "artificial lens with photocatalytic coating" is to coat the surface of the artificial lens with photocatalytic substances, which are excited by light to generate free radicals, thereby eliminating the anterior chamber. microorganisms, preventing and inhibiting endophthalmitis; although they can inhibit endophthalmitis to a certain extent by improving the surface properties or stimulating surrounding anti-inflammatory substances, they still have the following disadvantages: 1) The range of influence is limited to the surface of the artificial lens Or in the nearby area, the range is not enough, and the antibacterial ability is limited; 2) The inhibitory effect and degree of hydrophilicity or free radicals on endophthalmitis are not sure, and the adjustability is not high.
Although they can inhibit the proliferation of residual lens epithelial cells through in situ antibody inhibition or local concentration of drugs, they can only play a role through contact antibody inhibition, and the range of inhibition is small; or all The formed drug coating has poor stability, and there is a high possibility of sudden drug release, which may have toxic side effects on other tissues in the eye

Method used

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  • Artificial lens with drug sustained release micro-capsules inlaid on loop and manufacturing method thereof
  • Artificial lens with drug sustained release micro-capsules inlaid on loop and manufacturing method thereof
  • Artificial lens with drug sustained release micro-capsules inlaid on loop and manufacturing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0056] In this embodiment, the manufacturing method of the intraocular lens with anti-inflammatory drug slow-release microcapsules inlaid on the loop includes the following steps:

[0057] A one-piece intraocular lens is used, and a 500-micron round hole (haptic hole) is respectively carved at the root of the two haptics, that is, at the junction with the optics, for inlaying anti-inflammatory and anti-post-cataract drugs. Slow-release microcapsules.

[0058] Dissolve 300mg of gatifloxacin powder in 3ml of 1% hydrochloric acid, shake until clear, add 3ml of 1% sodium hydroxide solution, shake, then add 17ml of 0.2% by weight sodium alginate solution In the medium, shake and mix thoroughly until it is clear without precipitation, so as to obtain a sodium alginate solution containing gatifloxacin with a concentration of 15mg / ml; suck the above solution into a 50ml syringe, connect it to a microcapsule generator, adjust the machine parameters, and the diameter of the nozzle 300μ...

Embodiment 2

[0060] In this embodiment, the manufacturing method of the intraocular lens with anti-post-cataract drug slow-release microcapsules inlaid on the haptics is different from Example 1 in the difference of the material of the microcapsule material and the type and effect of the drug contained Different, but the preparation method of the microcapsule and the reagents and methods used for subsequent assembly are the same as in Example 1.

[0061] In this example, the selected drug is different from that in Example 1. It is a drug with anti-cataract effect, specifically, it has been discovered in recent years and has a good anti-post-cataract effect against post-cataract complications. Alkylphosphocholine drugs. The drug selected in this embodiment is miltefosine, and the main mechanism of this drug to inhibit post-cataract is to regulate the permeability and fluidity of the lens cell membrane, affect the enzymes of its cell signal transmission pathway, and change the composition of...

Embodiment 3

[0063] In this embodiment, the method for making an intraocular lens with anti-inflammatory and anti-post-cataract drug slow-release microcapsules inlaid on the loop is different from Example 1 and Example 2 in that the drug used is an anti-inflammatory drug. Different non-steroidal anti-inflammatory drugs, different microsphere cores, and different layer-by-layer self-assembled polyelectrolytes.

[0064] In this example, the specific drug used that is different from Example 1 and Example 2 is the non-steroidal anti-inflammatory drug bromfenac sodium, which can inhibit arachidonic acid by inhibiting cyclooxygenase-2, Ultimately prevent the biosynthesis and release of prostaglandins, prevent the stimulation and damage of inflammatory mediators to the eye, and play an anti-inflammatory and analgesic effect on eye inflammation. In addition, bromfenac sodium can also inhibit the proliferation of lens epithelial cells, Migration and transdifferentiation, thereby inhibiting post-cat...

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Abstract

The invention relates to an artificial lens with drug sustained release micro-capsules inlaid on a loop and a manufacturing method of the artificial lens. The artificial lens can suppress microbial infection and the like after a cataract surgery effectively. The manufacturing method is simple, mature and practical. The artificial lens with the drug sustained release micro-capsules inlaid on the loop is characterized in that at least one loop hole is formed in the loop, and the sustained release micro-capsules are inlaid in the loop holes. The manufacturing method comprises the following steps: 1) the loop holes are carved in the loop of the artificial lens, ultrasonic cleaning is conducted to the holes and the holes are reserved; 2) inner cores of the micro-capsules are prepared; 3) a plurality of layers of nanometer films are arranged on the inner surface layer of the inner core of each micro-capsule in a self-assembly mode; 4) the obtained micro-capsules are stored in cold, vacuum drying is conducted to the micro-capsules so that dry capsules without water are obtained; 5) the dry micro-capsules are inlaid in the loop holes of the artificial lens under a microscope, and therefore the artificial lens with the drug sustained release micro-capsules inlaid on the loop is manufactured; and then ethylene oxide sterilization and sealed package are conducted.

Description

technical field [0001] The invention relates to a foldable intraocular lens used in phacoemulsification cataract extraction to replace the intraocular lens, in particular to a loop mosaic capable of inhibiting microbial infection after cataract surgery, antagonizing inflammation, and preventing and inhibiting post-cataract Intraocular lens with drug sustained-release microcapsules and its manufacturing method. Background technique [0002] Cataracts are the leading cause of blindness worldwide; the only current treatment for cataracts is surgical removal of the cataract and implantation of an intraocular lens. Although cataract surgery has developed quite maturely, there are still some potential postoperative complications that may lead to vision loss or even blindness after surgery; such as bacterial endophthalmitis and post-cataract after cataract surgery. Most infectious endophthalmitis occurs after surgery, and 90% of cases are caused by bacteria (mostly from cataract s...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61F2/16A61M31/00A61L27/54A61L27/50
Inventor 姚克滕文琪崔建涛
Owner SECOND AFFILIATED HOSPITAL ZHEJIANG UNIV COLLEGE OF MEDICINE
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