Engineering high-efficiency counter-current chromatography equipment

Abstract

The invention discloses engineering high-efficiency counter-current chromatography equipment. The high-efficiency counter-current chromatography equipment comprises a machine base, wherein the machine base is provided with a planet carrier which can rotate relative to the machine base, the planet carrier is connected with a driving device for driving the planet carrier to rotate, and the planet carrier is provided with a planet shaft which is provided with a planetary wheel; and according to the key point of the technical scheme, multiple spiral-winding spiral separation tubes are wound outside the planetary wheel, and ratio of the winding semidiameter r1 of the innermost layer of spiral separation tube to the winding semidiameter r2 of the outermost layer of spiral separation tube is 0.85-1. The engineering high-efficiency counter-current chromatography equipment provided by the invention aims to overcome the deficiency of the prior art, the winding semidiameters of the multi-layer of spiral tubes are controlled so as to achieve high beta value.

Description

【Technical field】 [0001] The invention relates to a countercurrent chromatographic device. 【Background technique】 [0002] Countercurrent Chromatography (CCC) is a liquid-liquid partition chromatography technique invented by the National Institutes of Health in the United States. In 1970, it discussed the relationship between two immiscible liquid phases in a moving spiral tube. The scientific discovery of frequent distribution and transmission has laid a theoretical foundation for the development of CCC technology. From 1970 to 1980, he created the "flow-through planetary helical tube centrifuge" in the laboratory, which provided a basic physical model for the birth and development of countercurrent chromatographic separation instruments. According to the needs of the separation and identification of the components of antibiotics and other drugs in my country, my country has initiated the research work of CCC technology in the laboratory in Beijing since 1978, and independ...

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Problems solved by technology

In particular, the large-scale countercurrent chromatography equipment that has been reported has failed to fully retain the basic technical conditions of high-speed countercurrent chromatography while expanding the capacity of the separation column, namely: the column type of the multi-layer spiral column, the wound spiral column The limited inner diameter of the tube, high enough planetary motion speed, large β value coverage interval, high stationary phase retention rate, etc.

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