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Alfacalcidol capsules and preparation method thereof

A technology of alfacalcidol and capsules, applied in capsule delivery, bone diseases, pharmaceutical formulations, etc., can solve problems such as low bioavailability, poor disintegration and dissolution effects, and affect treatment effects, and achieve high bioavailability, Rapid dissolution and good stability

Active Publication Date: 2013-05-22
CP PHARMA QINGDAO CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] Existing alfacalcidol capsules have the defects of poor disintegration and dissolution effect and low bioavailability, which affect its clinical therapeutic effect. Therefore, it is necessary to develop alfacalcidol capsules with short disintegration time and rapid drug dissolution. Alcohol Capsules

Method used

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  • Alfacalcidol capsules and preparation method thereof
  • Alfacalcidol capsules and preparation method thereof
  • Alfacalcidol capsules and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0019] The preparation of embodiment 1 alfacalcidol capsules

[0020] Each component is weighed according to the following weight percentage:

[0021]

[0022] Mix alfacalcidol, fillers, disintegrants, surfactants, diluents, lubricants, glidants and flavoring agents uniformly; crush through a 120-mesh sieve to make granules, and put them into capsules to obtain the product.

Embodiment 2

[0023] The preparation of embodiment 2 alfacalcidol capsules

[0024] Each component is weighed according to the following weight percentage:

[0025]

[0026]

[0027] Mix alfacalcidol, fillers, disintegrants, surfactants, diluents, lubricants, glidants and flavoring agents uniformly; crush through a 120-mesh sieve to make granules, and put them into capsules to obtain the product.

Embodiment 3

[0028] The preparation of embodiment 3 alfacalcidol capsules

[0029] Each component is weighed according to the following weight percentage:

[0030]

[0031] Mix alfacalcidol, fillers, disintegrants, surfactants, diluents, lubricants, glidants and flavoring agents uniformly; crush through a 120-mesh sieve to make granules, and put them into capsules to obtain the product.

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Abstract

The invention discloses alfacalcidol capsules and a preparation method of the alfacalcidol capsules. The alfacalcidol capsules comprise alfacalcidol and formulation excipients, wherein the formulation excipients comprise a filler, a disintegrant, a surfactant, a diluent, a lubricant, a glidant and a flavoring agent. The alfacalcidol capsules disclosed by the invention have the advantages of quickness in dissolution, fastness in absorption, high bioavailability, good stability and convenience in taking.

Description

technical field [0001] The invention relates to capsules, in particular to alfacalcidol capsules and a preparation method thereof, and belongs to the field of alfacalcidol capsules. Background technique [0002] Alfacalcidol regulates the balance of calcium and phosphorus in the body, increases the absorption of calcium and phosphorus in the intestine, reduces the level of parathyroid hormone in plasma, and improves women's menopause and osteoporosis caused by hormone drugs . It is suitable for the prevention and treatment of osteoporosis, nephrogenic bone disease (nephrotic rickets, hyperparathyroidism (with bone disease), hypoparathyroidism, rickets and osteomalacia caused by nutritional and absorption disorders, false Rickets and osteomalacia due to calcium deficiency (D-dependent type I). [0003] Capsules can cover the bad smell of medicines and are easy to swallow; they can improve the stability and bioavailability of medicines; they can also release medicines at a f...

Claims

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Application Information

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IPC IPC(8): A61K9/48A61K31/592A61K47/38A61K47/36A61K47/32A61K47/34A61P19/08A61P19/10A61P3/02
Inventor 王明刚陈阳生任莉
Owner CP PHARMA QINGDAO CO LTD
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