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Tablet and preparation method

A tableting and tableting technology, applied in the field of medicine, can solve problems such as sticking and punching, and achieve the effect of good application prospects

Inactive Publication Date: 2013-05-15
SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] The present invention aims to solve the current technical problem of viscous and poor fluidity drugs in the direct compression process of tablets, and provides a tablet. The reasonable proportion of the tablet can effectively overcome the problem of sticking and punching during the tableting process, and the indicators of the final prepared tablet all meet the requirements of the Pharmacopoeia.

Method used

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Examples

Experimental program
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preparation example Construction

[0037] Tablet preparation method of the present invention comprises the following steps:

[0038] Grinding, mixing, and drying 2.5% to 3.5% of the lubricant and 20% to 50% of the main ingredient to obtain a mixture 1;

[0039] Pulverize and mix 1.5% to 2% of glidants and 32% to 64% of fillers to obtain mixture 2;

[0040] Mix 10% to 15% of binder, 1% to 1.5% of glidant, and 1% to 2% of disintegrant to obtain mixture 3;

[0041] Mix the mixtures 1, 2, and 3, dry, and pass through a 60-100 mesh sieve;

[0042] Tablets are obtained by using a rotary tablet press at a pressure of 8000N to 11000N and a speed of 10 to 15 rpm.

[0043] Another tablet preparation method of the present invention comprises the following steps:

[0044] Grinding, mixing, and drying 2.5% to 3.5% of the lubricant and 20% to 50% of the main ingredient to obtain a mixture 1;

[0045] Pulverize and mix 1.5% to 2% of glidants and 27% to 57% of fillers to obtain mixture 2;

[0046] Mix 10% to 15% of binder...

Embodiment 1

[0058] 1. Components and their weight percentages:

[0059]

[0060] 2. Preparation method:

[0061] To prepare lipoic acid powder, put 60-80 mesh food-grade lipoic acid raw materials into a tank mixer for crushing, so that the fluidity of the main drug lipoic acid is greatly increased, and through a 60-80 mesh sieve, lipoic acid is obtained Powder.

[0062] Weigh 3% lubricant magnesium stearate and food-grade lipoic acid powder and fully mix to obtain mixture 1. Magnesium stearate with fine particle size can effectively improve the fluidity of lipoic acid powder and make its angle of repose In the original 50°~60° tends to 30°~40° (see figure 1 ), providing a good foundation for the subsequent direct compression.

[0063] Weigh 57% of the filler microcrystalline cellulose and 2% of the glidant talcum powder and put them into a tank mixer for sufficient pulverization and mixing to obtain a mixture 2.

[0064] 1% micronized silica gel, 10% hydroxypropyl cellulose with fi...

Embodiment 2

[0067] 1. Components and their weight percentages:

[0068]

[0069]

[0070] Two, preparation method: with the preparation method of embodiment 1.

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PUM

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Abstract

The invention discloses a tablet, which comprises a main drug, a lubricant, a flow aid, a filler, an adhesive and a disintegrating agent. The invention also discloses a preparation method of the tablet, which comprises the following steps: using a proper amount of lubricant and main drug, crushing and mixing, increasing the fluidity of the main drug; mixing the flow aid and the filler of the tablet to increase the fluidity of the filler; selecting the proper adhesive and mixing with the flow aid and the disintegrating agent, and uniformly mixing with a generated mixture and then sieving; and using a conventional rotation tablet press for tabletting under proper pressure and speed condition. The tablet and the preparation method can effectively solve the sticking problem during a straight press process of the tablet, and the hardness, the disintegration time, the friability and the dissolution rate of the obtained tablet accord with a national pharmacopeia standard.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a tablet and a preparation method thereof. Background technique [0002] So far, many drugs have sticky problems in the process of direct compression, especially some drugs with high viscosity and poor fluidity. Generally, these drugs are made into dosage forms such as capsules and granules, even if they are made into tablets. Exist the problem that content is little, take many times more. This has also just caused the trouble of patient's taking medicine and manufacturer expends more manpower and material resources on process research, has increased investment on equipment. At the same time, many Chinese medicinal materials have a large dose of active ingredients, but they cannot be made into tablets because of their high viscosity. They encounter many obstacles when exporting to the European Union, North America and other countries. The barriers to entry into the EU market a...

Claims

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Application Information

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IPC IPC(8): A61K9/20A61K47/38A61K47/32A61K47/26A61K47/02
Inventor 高申戴子渊朱全刚丁雪鹰高静刘继勇王晓宇张敏张丽娟
Owner SECOND MILITARY MEDICAL UNIV OF THE PEOPLES LIBERATION ARMY
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