Hydroxydecyl quinone derivative for treating or preventing nerve diseases
The technology of a drug and a compound, which is applied in the field of pharmaceutical use of 6--2,3-dimethoxy-5-methyl-1,4-benzoquinone, can solve disorientation and does not relieve elderly surgical patients Post-anesthesia effects, impaired cognitive function, etc.
- Summary
- Abstract
- Description
- Claims
- Application Information
AI Technical Summary
Problems solved by technology
Method used
Image
Examples
Embodiment 1
[0134] Embodiment 1: preparation compound of the present invention
[0135] The general reaction process of the present embodiment is as follows:
[0136]
[0137]
[0138] (i), the preparation of 10-acetoxydecanoic acid (2)
[0139] In the reaction flask, add sodium hydroxide 115g (2.875mol), water 40ml, castor oil 150g and mixed cresol 45g, stir in 180~195 ℃ (reaction initial stage has frothing phenomenon, needs rapid stirring), reflux 3h. The volatile matter was removed by distillation, 1.5 L of water was added to the residue, the pH was adjusted to acidic with 50% sulfuric acid (containing Congo red), and heated to boiling. Separate the oil layer with a preheated separatory funnel, wash with ether, and dry over anhydrous sodium sulfate. Filtrate, recover the solvent from the filtrate, add 350ml of acetic anhydride to the residue, heat, stir and reflux for 5~6h, pour the reactant into an appropriate amount of ice, and place it overnight. Extracted several times wi...
Embodiment 2
[0152] Embodiment 2: preparation compound of the present invention
[0153] Use embodiment 1 step (vi) gained product, carry out according to the method for embodiment 1 step (vii), difference is to use: 5mL dichloromethane is good solvent, 5mL sherwood oil is the first antisolvent, 15ml cyclohexane is Second anti-solvent; crystallization cooling rate is 0.05°C / min. The yield was 91.3%. mp54.5~55°C.
Embodiment 3
[0154] Embodiment 3: preparation compound of the present invention
[0155] Use embodiment 1 step (vi) gained product, carry out according to the method for embodiment 1 step (vii), difference is to use: 4mL dichloromethane is good solvent, 7mL n-pentane is the first anti-solvent, 13ml n-hexane is The second anti-solvent; the crystallization cooling rate is 0.5°C / min. The yield was 90.9%. mp54~54.5°C.
PUM
Abstract
Description
Claims
Application Information
- R&D Engineer
- R&D Manager
- IP Professional
- Industry Leading Data Capabilities
- Powerful AI technology
- Patent DNA Extraction
Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic, Popular Technical Reports.
© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap|About US| Contact US: help@patsnap.com