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Corneal contact lens nursing composition containing trehalose quaternary ammonium salt

A corneal contact lens, quaternary ammonium salt technology, applied in the directions of glasses/goggles, glasses/protective glasses, drug delivery, etc., can solve the problems of corneal hypoxia, lack of tears, hinder the contact between cornea and air, etc., to reduce mortality , Promotes repair, relieves dryness and soreness

Inactive Publication Date: 2013-05-08
JIANGSU HORIEN CONTACT LENS
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0003] Existing soft contact lenses have high hydrophilicity. Because the contact lenses are worn into the eyes, they cover the front of the cornea, hindering the contact between the cornea and air and causing corneal hypoxia. In addition, tears can moisten the cornea , outside the conjunctiva, the lens must also be moistened, resulting in a lack of tears, causing dryness and soreness in the eyes of the lens wearer

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0018] Trehalose quaternary ammonium salt 2%, isotonicity regulator: sodium chloride 0.36%, potassium chloride 0.04%, surfactant: poloxamer 0.2%, complexing agent: edetate disodium 0.1%, Buffer: boric acid 0.64%, borax 0.09%, antimicrobial agent: polyhexamethylene biguanide (PHMB) 0.000018%, water 96.569992%.

Embodiment 2

[0020] Trehalose quaternary ammonium salt 1%, isotonicity adjuster: sodium chloride 0.5%, surfactant: poloxamer 0.2%, complexing agent: disodium edetate 0.1%, buffer: boric acid 0.64% , Borax 0.09%, antimicrobial agent: polyhexamethylene biguanide 0.000018%, water 97.46009%.

Embodiment 3

[0022] Trehalose quaternary ammonium salt 0.5%, isotonic adjustment agent: sodium chloride 0.6%, surfactant: sodium lauroyl glutamate 0.15%, complexing agent: disodium edetate 0.1%, buffering agent : Disodium hydrogen phosphate 0.17%, sodium dihydrogen phosphate 0.03%, antimicrobial agent: polyhexamethylene biguanide 0.00001%, alexidine (Alexidine) 0.00004%, water 98.45%.

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PUM

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Abstract

A corneal contact lens nursing composition containing trehalose quaternary ammonium salt is provided; the corneal contact lens nursing composition is characterized by consisting of the following components in percentage by weight: 0.001-2% of trehalose quaternary ammonium salt, 0.01-2% of isotonic regulator, 0.05-2% of surfactant, 0.01-1% of complexing agent, 0.01-3% of buffer, 0.00001-1% of anti-microorganism compound and 89-99.91899% of water. The composition provided by the invention has corneal contact lens storing, sterilizing, cleaning, lubricating, hydrating and anti-drying functions and is very effective for relieving dryness and stiffness of eyes; by adopting the composition, the death rate of corneal epithelial cells under a dry condition is reduced and the repairing of corneal epithelial cells and endothelial cells is prompted. The kill rate of each composition to escherichia coli, pseudomonas aeruginosa and staphylococcus aureus is greater than 99.9% and the kill rate to candida albica and solanaceae fusarium is greater than 90.0%.

Description

technical field [0001] The invention relates to a composition for corneal contact lens care. Specifically, the composition is a contact lens care composition including trehalose quaternary ammonium salt. Background technique [0002] Contact lenses can be divided into three types: rigid, semi-rigid and soft. Rigid contact lenses are made of polymethyl methacrylate (PMMA) that is basically impermeable to oxygen and siloxane and acrylate copolymers that are permeable to oxygen. Semi-rigid contact lenses are made of silicone rubber that is permeable to oxygen and can maintain the normal respiration of the corneal surface. It needs to use a special wetting solution to keep it moist to meet the comfort and physiological requirements; Soft contact lenses, most commonly lenses made of polyhydroxyethylmethacrylate (HEMA). The HEMA molecule has a network structure, which enables the lens to absorb and release low-molecular liquid. The looser the network structure of the lens, the h...

Claims

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Application Information

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IPC IPC(8): A61L12/14A61L12/12G02C13/00A61L101/50A61L101/32A61L101/44
CPCA61L12/14G02C13/00A61L12/12A01N47/44A61K9/0051Y02A50/30A01N25/30A01N2300/00
Inventor 何坚
Owner JIANGSU HORIEN CONTACT LENS
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