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Venlafaxine sustained-release capsule and preparation process thereof

A technology for sustained-release capsules and venlafaxine, which is applied in the directions of non-active ingredients medical preparations, active ingredients-containing medical preparations, organic active ingredients, etc., can solve the problem of accelerating drug release, increasing osmotic pressure, and increasing production costs. and other problems, to achieve the effect of slowing the release rate, reducing the solubility, and reducing the osmotic pressure

Active Publication Date: 2013-04-24
珠海天翼医药技术开发有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

This type of method has the following deficiencies: 1. The blank pellet core is easy to disintegrate or dissolve too quickly, which increases osmotic pressure and accelerates drug release. Therefore, it is necessary to increase the thickness of the slow-release coating layer, which increases the production cost, and does not achieve a good effect. Sustained release effect; 2. The coating process is relatively complicated, and it needs to be coated in a fluidized bed or a coating pan after the drug-containing pellets are made by a centrifugal granulator or a centrifugal spheronizer

Method used

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  • Venlafaxine sustained-release capsule and preparation process thereof
  • Venlafaxine sustained-release capsule and preparation process thereof

Examples

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preparation example Construction

[0046] A preparation method for venlafaxine sustained-release capsules, comprising the following steps:

[0047] 1) Weigh the adhesive according to the prescription amount, and prepare a 10-30% (g / mL) adhesive solution with ethanol for later use;

[0048] 2) Put the blank core in the granulator, weigh the binder solution and filler according to the prescription, spray the liquid and powder, so that the binder and filler are evenly dispersed and deposited on the blank core to form an isolated pellet. Floor;

[0049] 3) take binder solution and venlafaxine by prescription quantity, spray liquid and apply powder, make binder and venlafaxine evenly disperse and deposit on the isolation layer, make drug-containing layer, obtain drug-containing micropill;

[0050] 4) Then, weigh the binder solution and the filler according to the prescription amount, spray the liquid and apply the powder, so that the binder and the filler are evenly dispersed and deposited on the drug-containing la...

Embodiment 1

[0057] The sustained-release pellets consist of the following components by weight from the inside to the outside:

[0058] Sucrose blank core 10

[0059] isolation layer 5

[0060] Drug-containing layer 20

[0061] Slow Release Protective Layer 10

[0062] 1) Weigh ethyl cellulose and enteric acrylic resin in a weight ratio of 1:0.5 and mix them evenly as a binder, prepare a 15% (g / mL) binder solution with ethanol for later use; weigh talcum powder as a filler agent spare;

[0063] 2) Put the blank pellet core in the centrifugal granulator, take the binder solution and filler (the weight ratio of binder to filler is 1:4), spray liquid and powder, make the binder and filler Evenly disperse and deposit on the blank pellet core to make an isolation layer;

[0064] 3) Next, take the binder solution and venlafaxine (the weight ratio of binder to venlafaxine is 1:7), spray liquid and powder, so that the binder and venlafaxine are uniformly dispersed and deposited on the isolatio...

Embodiment 2

[0069] The sustained-release pellets consist of the following components by weight from the inside to the outside:

[0070] Starch blank core 15

[0071] isolation layer 10

[0072] Drug-containing layer 10

[0073] Slow Release Protective Layer 20

[0074] 1) Weigh ethyl cellulose and enteric acrylic resin in a weight ratio of 1:0.2 and mix them evenly as a binder, prepare a 10% (g / mL) binder solution with ethanol for later use; weigh talcum powder as a filler agent spare;

[0075] 2) Put the blank pellet core in the centrifugal granulator, take the binder solution and filler (the weight ratio of binder to filler is 1:6), spray liquid and powder, make the binder and filler Evenly disperse and deposit on the blank pellet core to make an isolation layer;

[0076] 3) Next, take the binder solution and venlafaxine (the weight ratio of binder to venlafaxine is 1:5), spray liquid and powder, so that the binder and venlafaxine are uniformly dispersed and deposited on the isolat...

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Abstract

The invention discloses a venlafaxine sustained-release capsule and a preparation process thereof. Ethyl cellulose and enteric acrylic acid resin are compounded as an adhesive; an isolation layer is coated outside a blank pellet, so that the pellet is not released at all, the osmotic pressure inside a sustained-release pellet is reduced, and the release speed of the medicine is decelerated; and meanwhile the adhesive is used for a medicine-containing layer and a sustained-release protection layer, so that venlafaxine medicine layers are encapsulated in a sustained-release material, the dissolubility of the pellet is further reduced, and the stable release of the medicine is guaranteed to reach a standard requirement.

Description

technical field [0001] The invention relates to a venlafaxine sustained-release capsule and a preparation process thereof. Background technique [0002] Venlafaxine is a drug for the treatment of depression. The half-lives of venlafaxine and its active metabolite O-desmethylvenlafaxine are 5 hours and 12 hours respectively. In order to achieve a stable blood concentration, it is necessary to take 2 hours a day. Or 3 times, taking it multiple times will lead to greater side effects, such as nausea and vomiting. Making venlafaxine sustained-release preparations can reduce the number of medications, reduce side effects, improve patient compliance, and improve therapeutic effect. Therefore, venlafaxine sustained-release preparations have been widely used in clinical practice. [0003] Sustained-release preparations can generally be divided into skeleton-type pellets, membrane-controlled pellets, and pellets made of a combination of the two according to the composition structure...

Claims

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Application Information

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IPC IPC(8): A61K9/52A61K31/137A61K47/38A61P25/24
Inventor 张晓明麦耀权曾万溪王美娟杨航
Owner 珠海天翼医药技术开发有限公司
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