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Preparation method and application of sulfur and phosphorus composite artificial bone

A composite, artificial bone technology, applied in medical science, prosthesis, etc., can solve the problem of the mismatch between the rate of degradation and the rate of new bone formation, and achieve the effect of solving the mismatch between the rate of degradation and the rate of new bone formation and accelerating repair.

Active Publication Date: 2013-04-17
浙江嘉佑医疗器械有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0005] In view of the above problems, the present invention provides a preparation and application of a sulfur-phosphorus composite artificial bone to solve the problem that the degradation rate of traditional artificial bone does not match the rate of new bone formation in the process of filling and repairing bone defects

Method used

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  • Preparation method and application of sulfur and phosphorus composite artificial bone
  • Preparation method and application of sulfur and phosphorus composite artificial bone
  • Preparation method and application of sulfur and phosphorus composite artificial bone

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Experimental program
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Effect test

Embodiment 1

[0030] According to the chemical composition requirements of the sulfur-phosphorus composite artificial bone, a certain amount of calcium sulfate hemihydrate, tricalcium phosphate, and calcium dihydrogen phosphate were weighed to form solid ingredients. Among them, tricalcium phosphate accounts for 22.5% of the total mass of solid ingredients, and the particle size of tricalcium phosphate is (100~600) μm; calcium sulfate hemihydrate accounts for 70% of the total mass of solid ingredients, and the particle size of calcium sulfate hemihydrate is (10~100) μm; calcium dihydrogen phosphate accounts for 7.5% of the total mass of solid ingredients, and the particle size of calcium dihydrogen phosphate is (50~300) μm. Pour the solid ingredients into the v-shaped barrel mixer and mix for 40 minutes at a rate of 20r / min. Then pour the mixed material into the kneader, add 130ml of normal saline, and stir and knead for 120s. Take out the kneading material and pour it on the rubber templa...

Embodiment 2

[0032] According to the chemical composition requirements of the sulfur-phosphorus composite artificial bone, a certain amount of calcium sulfate hemihydrate, tricalcium phosphate, and calcium dihydrogen phosphate were weighed to form solid ingredients. Among them, tricalcium phosphate accounts for 37.5% of the total mass of solid ingredients, and the particle size of tricalcium phosphate is (100~600) μm; calcium sulfate hemihydrate accounts for 50% of the total mass of solid ingredients, and the particle size of calcium sulfate hemihydrate is (10~100) μm; calcium dihydrogen phosphate accounts for 12.5% ​​of the total mass of solid ingredients, and the particle size of calcium dihydrogen phosphate is (50~300) μm. Pour the solid ingredients into the v-shaped barrel mixer and mix for 40 minutes at a rate of 20r / min. Then pour the mixed material into the kneader, add 130ml of physiological saline, and stir and knead for 150s. Take out the kneading material and pour it on the rub...

Embodiment 3

[0034]According to the chemical composition requirements of the sulfur-phosphorus composite artificial bone, a certain amount of calcium sulfate hemihydrate, tricalcium phosphate, and calcium dihydrogen phosphate were weighed to form solid ingredients. Among them, tricalcium phosphate accounts for 52.5% of the total mass of solid ingredients, and the particle size of tricalcium phosphate is (100~600) μm; calcium sulfate hemihydrate accounts for 30% of the total mass of solid ingredients, and the particle size of calcium sulfate hemihydrate is It is (10~100) μm; calcium dihydrogen phosphate accounts for 17.5% of the total mass of solid ingredients, and the particle size of calcium dihydrogen phosphate is (50~300) μm. Pour the solid ingredients into the v-shaped barrel mixer and mix for 40 minutes at a rate of 20r / min. Then pour the mixed material into the kneader, add 130ml of physiological saline, and stir and knead for 150s. Take out the kneading material and pour it on the ...

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Abstract

The invention relates to preparation and application of a sulfur and phosphorus composite artificial bone, belonging to the technical field of the preparation and the application of artificial bone repairing materials for bone defect filling and replacing. According to the invention, an artificial bone product controllable in porosity and degradation speed can be prepared through taking tricalcium phosphate, calcium sulfate hemihydrate and monocalcium phosphate as raw materials, taking purified water or normal saline as an curing agent and regulating the proportion of the raw materials and the consumption of the curing agent, so that the problem of a traditional artificial bone that the degradation speed is not matched with the new bone forming speed in the bone defect filling and repairing processes is solved.

Description

technical field [0001] The invention relates to the preparation and application of a sulfur-phosphorus composite artificial bone, and belongs to the technical field of preparation and application of artificial bone repair materials used for bone defect filling and replacement. Background technique [0002] Clinically, bone defects caused by various reasons are usually repaired by bone grafting. Bone transplantation is currently the most common tissue transplant procedure after blood transfusion. According to statistics, 70% of nonunion and bone defects caused by bone fractures, 10% of total wrist fractures, 15% of bone and joint repairs, 85% of spinal fusion, 15% of cervical and facial bone repairs and 85% Bone graft material is used in all extraction wounds. Therefore, bone graft materials have broad market prospects and good room for growth. [0003] Currently, bone grafting materials used clinically mainly include autologous bone, allogeneic bone and artificial bone re...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L27/12A61L27/02
Inventor 李向军常婷朱颖陈静杜瑞林胡誉怀
Owner 浙江嘉佑医疗器械有限公司
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