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Traditional Chinese medicine itching-relieving gel and preparation method thereof

A technology of gel and traditional Chinese medicine, which is applied in the field of medicine, can solve the problems of low bioavailability, inconvenient use, poor transdermal absorption, etc., and achieve the effect of good colloidal compatibility, good release, and low viscosity

Active Publication Date: 2013-04-17
上海国创医药股份有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although hormone drugs have quick effects on anti-inflammation, antipruritic and exudation reduction, they recur soon after drug withdrawal, and long-term use can easily cause many adverse reactions, such as rough skin, enlarged pores and pigmentation
Although there are many traditional Chinese medicine treatment methods, there are few drugs for external use, and the traditional external preparations of traditional Chinese medicine are mostly lotions, powders, oils, fumigants, tinctures, etc., which are inconvenient to use, poor transdermal absorption, low bioavailability, Defects such as easy to fall off and affect the appearance

Method used

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  • Traditional Chinese medicine itching-relieving gel and preparation method thereof
  • Traditional Chinese medicine itching-relieving gel and preparation method thereof
  • Traditional Chinese medicine itching-relieving gel and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] The preparation of the decoction concentrate of the traditional Chinese medicine composition: Weigh Viola odorifera, Baixian peel, and Sophora flavescens at a mass ratio of 2:1:1, add water and decoct twice for 1 hour each time, filter, combine the filtrate, and combine The liquid is concentrated under low temperature and decompression (below 70°C) to 1.674g crude drug / g concentrated solution.

[0023] Preparation of traditional Chinese medicine antipruritic gel: Weigh 12 parts of hydroxyethyl cellulose, 3 parts of carrageenan, 5 parts of Avidin CL-611, 4 parts of sodium hydroxide, add 350 parts of distilled water, and heat in a water bath at 80℃ , Stir well and swell into a transparent solution, continue to add 100 parts of glycerin, 50 parts of absolute ethanol, 15 parts of azone, continue to stir to prepare a gel matrix; then add the anti-itch and anti-inflammatory traditional Chinese medicine concentrate to the gel matrix Stir 539 parts evenly and cool down at low temp...

Embodiment 2

[0025] The preparation of the decoction concentrate of the traditional Chinese medicine composition: Weigh Viola odorifera, Baixian peel, and Sophora flavescens at a mass ratio of 2:1:1, add water to decoct twice, 3 hours each time, filter, combine the filtrate, and combine The liquid is concentrated under low temperature and reduced pressure (below 70℃) to 1.600g crude drug / g of concentrated solution.

[0026] Preparation of traditional Chinese medicine antipruritic gel: Weigh 13 parts of hydroxyethyl cellulose, 1.5 parts of carrageenan, 118 parts of Aiweisuo CL-6, 10 parts of sodium hydroxide and 350 parts of distilled water, then heat in a water bath at 80℃ and stir. After uniformly swelling into a transparent solution, continue to add 100 parts of glycerin, 50 parts of absolute ethanol, 15 parts of azone, and continue to stir to prepare a gel matrix; then add 273.75 parts of antipruritic and anti-inflammatory traditional Chinese medicine concentrate to the gel matrix Stir eve...

Embodiment 3

[0028] Preparation of the concentrated decoction of the traditional Chinese medicine composition: Weigh Viola odorifera, Baixian peel, and Sophora flavescens at a mass ratio of 2:1:1, add water and decoct twice for 2 hours each time, filter, combine the filtrate, and combine the The liquid is concentrated under low temperature and decompression (below 70℃) to 1.700g crude drug / g concentrated solution.

[0029] Preparation of traditional Chinese medicine antipruritic gel: Weigh 14 parts of hydroxyethyl cellulose, 6.5 parts of Aiweisu CL-611 and 400 parts of distilled water, heat it in a water bath at 80°C, stir evenly, and continue to swell into a transparent solution. Add 100 parts of glycerin, 50 parts of absolute ethanol, 15 parts of azone, and continue to stir to prepare a gel matrix; then add 390 parts of antipruritic and anti-inflammatory traditional Chinese medicine concentrate to the gel matrix, stir evenly, and cool down. The above parts are calculated by mass parts.

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Abstract

The invention belongs to the technical field of medicines and relates to traditional Chinese medicine itching-relieving gel. The traditional Chinese medicine itching-relieving gel is prepared from raw materials comprising Chinese violet, cortex dictamni and sophora flavescens at a mass ratio of 2:1:1. The invention further relates to a preparation method of the traditional Chinese medicine itching-relieving gel. The preparation method comprises the following steps: (1) performing preparation of concentrated solution decocted with water of a traditional Chinese medicine; (2) performing preparation of gel substrate; and (3) finally adding the concentrated solution decocted with the water of the itching-relieving traditional Chinese medicine to the gel substrate, uniformly stirring, and cooling down at low temperature. According to the preparation method provided by the invention, the auxiliary of the gel comprises the following components in parts by weight: 12-14 parts of hydroxyethyl cellulose, 5-8 parts of avicel CL-611, 100 parts of glycerol, 50 parts of absolute ethyl alcohol, 15 parts of azone, 300-400 parts of distilled water, 0-3 parts of carrageen and 0-1 part of sodium hydroxide. The traditional Chinese medicine itching-relieving gel disclosed by the invention is applied to medicines for treating skin itch caused by various reasons, such as eczema, urticaria and pruritus; and in addition, cosmeceuticals can be prepared by adding 5-10 parts of lavender essential oil or menthol essential oil to the traditional Chinese medicine itching-relieving gel.

Description

Technical field [0001] The invention belongs to the technical field of medicine, and in particular relates to an antipruritic Chinese medicine gel and a preparation method and application of the gel. technical background [0002] Skin pruritus is the most common disease in dermatology clinics. Clinically, patients with only skin pruritus without primary skin damage are called pruritus, which is called wind pruritus in Chinese medicine, which belongs to the category of Chinese medicine "itch wind". Mainly manifested as dry skin, desquamation, excessive itching, skin ulceration, multiple scratches, and blood scabs may occur due to repeated scratching. There are many patients with pruritus caused by various reasons, and the disease is common and frequent, especially in elderly patients. Although pruritus does not cause serious harm, it will affect the patient’s mood, work and quality of life over time , Can cause insomnia or poor sleep, irritability, etc., so itching should be take...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/86A61K47/38A61K9/06A61P17/04A61P29/00
Inventor 张伟荣王冰干仲元丁阅异马梦雨葛臻方杭夏艳秋
Owner 上海国创医药股份有限公司
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