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Radix millettiae speciosae extract and application thereof in preparing drugs for treating osteoporosis

A technology of osteoporosis and extract, which is applied in the direction of drug combination, bone disease, medical formula, etc., to achieve the effect of low cost, avoiding large side effects, and simple preparation method

Inactive Publication Date: 2013-04-17
HAINAN NORMAL UNIV +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

The root of Niu Dali is used as medicine. After searching, the current pharmacological research on Niu Dali (the root of Niu Dali) mainly focuses on immune regulation, liver protection, anti-inflammation, anti-oxidation, free radical scavenging, anti-tumor, expectorant , antitussive, antiasthmatic, and anticoagulant effects, but there is no report on the application of drugs for the treatment of osteoporosis

Method used

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  • Radix millettiae speciosae extract and application thereof in preparing drugs for treating osteoporosis

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Effect test

Embodiment 1

[0021] The root of Niu Dali was dried and crushed into powder, and the powder was reflux extracted with 95% methanol for 3 times, the extracts were combined, filtered, and the methanol was recovered under reduced pressure to obtain the extract-like methanol crude extract, the methanol crude extract was diluted with water, and then Sequentially extract with petroleum ether, chloroform, and ethyl acetate, respectively concentrate the extracts under reduced pressure to the extract form, and vacuum-dry the powders obtained, respectively, the extracts from the petroleum ether part, the extract from the chloroform part, and the extract from the ethyl acetate part . After the extraction, the remaining aqueous solution is concentrated under reduced pressure to an extract, and the powder obtained by vacuum drying is the extract of the aqueous phase part of Niu Dali.

Embodiment 2

[0023] The root of Niu Dali was dried and crushed into powder, and the powder was reflux extracted with 95% ethanol for 4 times, the extracts were combined, filtered, and the ethanol was recovered under reduced pressure to obtain the extract-like ethanol crude extract, the ethanol crude extract was diluted with water, and then Sequentially extract with petroleum ether, chloroform, and ethyl acetate, respectively concentrate the extracts under reduced pressure to the extract form, and vacuum-dry the powders obtained, respectively, the extracts from the petroleum ether part, the extract from the chloroform part, and the extract from the ethyl acetate part . After the extraction, the remaining aqueous solution is concentrated under reduced pressure to an extract, and the powder obtained by vacuum drying is the extract of the aqueous phase part of Niu Dali.

Embodiment 3

[0025] The root of Niu Dali was dried and crushed into powder, and the powder was reflux extracted with 75% ethanol for 6 times, the extracts were combined, filtered, and the ethanol was recovered under reduced pressure to obtain the extract-like methanol crude extract, the ethanol crude extract was diluted with water, and then Sequentially extract with petroleum ether, chloroform, and ethyl acetate, respectively concentrate the extracts under reduced pressure to the extract form, and vacuum-dry the powders obtained, respectively, the extracts from the petroleum ether part, the extract from the chloroform part, and the extract from the ethyl acetate part . After the extraction, the remaining aqueous solution is concentrated under reduced pressure to an extract, and the powder obtained by vacuum drying is the extract of the aqueous phase part of Niu Dali.

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Abstract

The invention discloses a radix millettiae speciosae extract and an application of the radix millettiae speciosae extract in preparing drugs for treating osteoporosis. The radix millettiae speciosae extract is obtained by drying the roots of radix millettiae speciosae and crushing into powder, then refluxing with ethanol and extracting, filtering an extracting solution, decompressing and recycling a solvent completely. The radix millettiae speciosae extract is discovered with a good efficacy in treating osteoporosis on a basis of efficacy test, so that the radix millettiae speciosae extract can be used for preparing drugs for treating osteoporosis, and an effective way is provided for the treatment of osteoporosis, and moreover, the preparation method is simple, and the cost is low.

Description

technical field [0001] The invention belongs to the field of plant applications, and relates to a plant active extract and its application, in particular to a bovine herbaceous extract and its application in the preparation of medicines for treating osteoporosis. Background technique [0002] Osteoporosis (OP) is a systemic disease characterized by decreased bone mass, degeneration of bone microstructure, increased fragility, and susceptibility to fracture. Due to the high disability rate of osteoporosis, it greatly affects people's quality of life and brings a heavy economic burden to families and society. With the aging population, the problem of osteoporosis is becoming more and more prominent. [0003] Modern medicine believes that the basic pathological mechanism of osteoporosis is the imbalance of bone resorption and bone formation coupling in the process of bone metabolism, which leads to the imbalance of calcium and phosphorus metabolism in the human body and the cl...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/486A61P19/10
Inventor 韩长日陈光英张金超舒火明王呈文
Owner HAINAN NORMAL UNIV
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