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Degradable anti-adhesion compound membrane and preparation method thereof

A composite film and anti-adhesion technology, used in medical science, surgery, etc., can solve the problems of polyester-polyether copolymer mechanical strength limitation, loss, and difficulty in meeting the needs of surgery, so as to shield wounds and avoid wear and tear. Transparent and thin effect

Inactive Publication Date: 2013-04-03
ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Although polyether has an excellent effect on inhibiting fibroblasts, if pure polyether is blended with a degradable polyester material, the soluble polyether will first dissolve into the body fluid in the body and then be lost from the membrane, which will not achieve the desired effect on the membrane. Inhibitory effect of fibroblast proliferation on the surface of
[0006] The Chinese patent application whose publication number is CN 102344558A discloses the application of a polyester-polyether copolymer, and specifically discloses the use of the polyester-polyether copolymer as a medical anti-adhesion film, but the polyester-polyether The mechanical strength of the copolymer is limited, and it can only be prepared as a single-layer cast film in clinical practice. If the copolymer is made into a porous medical film, the strength is difficult to meet the needs of surgery.

Method used

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  • Degradable anti-adhesion compound membrane and preparation method thereof
  • Degradable anti-adhesion compound membrane and preparation method thereof
  • Degradable anti-adhesion compound membrane and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0045] Synthesis of polyester: place 50 grams of dehydrated and purified L-lactide and glycolide in a weight ratio of 85 / 15 in a 500ml reaction bottle, and then add a stannous octoate catalyst with a total weight of 0.02% of the polymerized monomers , 150 ° C under vacuum conditions for 15 hours to obtain a random polymer polyester. The polymer was dissolved in chloroform, precipitated in ethanol, and the precipitate was dried in a vacuum desiccator for 48 hours. The viscosity-average molecular weight of the product is 480,000, and the weight ratio of L-lactide accounts for 85% in the polyester as determined by nuclear magnetic 1H spectrum. The glass transition temperature was determined to be 57°C.

[0046] Synthesis of polyether-polyester copolymer: put 50 grams of dehydrated and purified L-lactide, glycolide and methoxy single-capped polyethylene glycol 5000 in 500ml according to the weight ratio of 85 / 15 / 100 Add 0.05% stannous octoate catalyst to the reaction bottle, and r...

Embodiment 2

[0055] The following synthetic method is similar to that in Example 1, and is briefly described as follows:

[0056] Synthesis of polyester-polyether: 50 grams of dehydrated and purified DL-lactide and polyethylene glycol in a weight ratio of 1 / 2 are placed in a 500ml reaction bottle, and the viscosity-average molecular weight of the product after the reaction is 4.5 Wan, by NMR 1 According to H spectrum measurement, the polyether accounts for 68% of the polyester-polyether copolymer in the polyether-DL-lactide copolymer.

[0057] Preparation of composite film: blend the same polyester as in Example 1 with the polyester-polyether in Example 2 in a 50 / 50 ratio to form a chloroform solution with a concentration of 5%, pour 120ml of the solution into a 50*50cm in the flat mold. It was left still at 40° C. and a humidity of 50%. When it is not completely dry but has lost its fluidity, it is transferred to the electrospinning drum for the preparation of the electrospun layer. P...

Embodiment 3

[0063] The following synthetic method is similar to that in Example 1, and is briefly described as follows:

[0064] Synthesis of polyester: Put DL-lactide, glycolide, and caprolactone that have been dehydrated and purified in a weight ratio of 70 / 15 / 15, and put a total of 50 grams into a 500ml reaction bottle, and then add 0.02 % stannous octoate catalyst was reacted for 48 hours at 140° C. under vacuum conditions to obtain polyester random polymers. The polymer was dissolved in chloroform, precipitated in ethanol, and the precipitate was dried in a vacuum desiccator for 48 hours. The viscosity-average molecular weight of the product is 300,000, and the glass transition temperature is 28°C as measured by experiments.

[0065] Preparation of composite film: blend polyester with polyester-polyether in Example 2 at a ratio of 50 / 50 to form a chloroform solution with a concentration of 5%, and pour 120ml of the solution into a 50*50cm flat-bottomed mold. Naturally volatilize at...

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Abstract

The invention discloses a degradable anti-adhesion compound membrane which has two layers, wherein one layer of the anti-adhesion compound membrane is a base membrane, and the other layer of the anti-adhesion compound membrane is an electrospinning film; a material of the base membrane and the electrospinning film is a blending material of polyester-polyether copolymer and polymer; and the blending material comprises the following components in percentage by weight, 10%-90% of polyester and 10%-90% of polyester-polyether copolymer. The anti-adhesion compound membrane can be excellently attached to tissues and has a good inhibition effect on fibroblasts, so that the tissues can be effectively isolated and the anti-adhesion effect is achieved. The invention further discloses a preparation method for the anti-adhesion compound film, and the electrospinning membrane of the prepared compound membrane has micro-grade holes and can be effectively attached to the tissues.

Description

technical field [0001] The invention belongs to the field of biomedical materials, and in particular relates to a degradable anti-adhesion composite film and a preparation method thereof. Background technique [0002] How to prevent wound adhesion in surgery has been a problem that has not been well resolved. The sequelae caused by tissue adhesion after surgery are: continuous pain at the surgical site, and partial loss of function at the surgical site. For example, adhesions caused after abdominal surgery may lead to intestinal obstruction, chronic pain, and even infertility, making the second surgery difficult. [0003] At present, in the internationally recognized adhesion mechanism, the massive proliferation of fibroblasts is one of the important reasons for the formation of adhesion. Earlier clinical reports mainly used drugs to inhibit the growth of fibroblasts, but the side effects were large, the inhibition could not be sustained, and the apposition between the two...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61L31/06A61L31/14A61B17/00
Inventor 马驰熊左春熊成东蒋国华刘如意陈栋梁庞秀炳
Owner ZHEJIANG APELOA JIAYUAN BIOMEDICAL MATERIAL
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