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Preparation method and application of brain-soothing hypertension pill

A technology of Jiangyao tablets and clearing brain, applied in the field of preparation of Qingnao Jiangya tablets, can solve the problems of large dosage, backwardness, and many impurities in patients, and achieve the effect of reducing the dosage

Active Publication Date: 2013-03-27
TONGHUA YUSHENG PHARMA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

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Problems solved by technology

[0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingnao Jiangya Tablets. However, the method of powdering and decocting in water is rough and backward in process and has many impurities, which leads to excessive dosage for patients and unnecessary It is convenient to take, which has seriously affected the clinical application of this product

Method used

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  • Preparation method and application of brain-soothing hypertension pill

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0025] Take 100g of Scutellaria baicalensis, 60g of Prunella vulgaris, 60g of Sophora japonica, 60g of calcined magnet, 60g of Achyranthes bidentata, 100g of angelica, 40g of rehmannia root, 40g of salvia miltiorrhiza, 20g of leech, 60g of uncaria, 100g of cassia seed, 20g of earthworm, 40g of mother-of-pearl. Join to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 4%, the extraction pressure is 15MPa, the temperature is 30°C, the CO2 flow rate is 1m1 / g crude drug min, and the extraction time is 150min to obtain a supercritical extract , set aside; take the rest of the traditional Chinese medicine, pulverize, add 2L of 70% ethanol, put it into a microwave extraction device for microwave extraction, extraction power 400W, extract twice, each time 4 minutes, combine the extracts, concentrate, add to D101 macropore adsorption On the resin column, elute with 50% ethanol, collect 5 tim...

Embodiment 2

[0028] Take 100g of Scutellaria baicalensis, 60g of Prunella vulgaris, 60g of Sophora japonica, 60g of calcined magnet, 60g of Achyranthes bidentata, 100g of angelica, 40g of rehmannia root, 40g of salvia miltiorrhiza, 20g of leech, 60g of uncaria, 100g of cassia seed, 20g of earthworm, 40g of mother-of-pearl. Join to CO 2 In a supercritical extractor, ethanol is used as an entrainer, and the volume percentage of the entrainer in the total extraction solvent is 6%, the extraction pressure is 30MPa, the temperature is 50°C, and the CO 2 The flow rate is 3m1 / g crude drug·min, the extraction time is 180min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, pulverized, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction, with an extraction power of 600W, and extracted twice. 8 minutes each time, combine the extracts, concentrate, add to D101 macroporous adsorption resin column, elute w...

Embodiment 3

[0031] Take 100g of Scutellaria baicalensis, 60g of Prunella vulgaris, 60g of Sophora japonica, 60g of calcined magnet, 60g of Achyranthes bidentata, 100g of angelica, 40g of rehmannia root, 40g of salvia miltiorrhiza, 20g of leech, 60g of uncaria, 100g of cassia seed, 20g of earthworm, 40g of mother-of-pearl. Join to CO 2 In the supercritical extractor, ethanol is used as an entrainer, and the entrainer accounts for 5% by volume of the total extraction solvent, the extraction pressure is 20MPa, the temperature is 40°C, and the CO 2 The flow rate is 2m1 / g crude drug·min, the extraction time is 160min, and the supercritical extract is obtained for use; the rest of the traditional Chinese medicine is taken, crushed, added 2L of 70% ethanol, and put into a microwave extraction device for microwave extraction. The extraction power is 500W, and the extraction is performed twice. Combine the extracts for 6 minutes each time, concentrate, add to D101 macroporous adsorption resin colu...

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Abstract

The invention provides a preparation method of a brain-soothing hypertension pill. The brain-soothing hypertension pill is prepared by using 100g of baical skullcap roots, 60g of common selfheal fruit-spike, 60g of sophora flower bud, 60g of forged lodestone, 60g of twotooth achyranthes roots, 100g of Chinese angelica, 40g of rehmannia, 40g of danshen roots, 20g of sanguisuga, 60g of uncaria rhynchophylla, 100g of semen cassia, 20g of lumbricus and 40g of nacre as bulk drugs and adopting supercritical extraction and microwave-assisted extraction modes. By adopting the method, the content of baicalin is greatly improved; and the invention also provides application of the brain-soothing hypertension pill in preparation of drugs for inhibiting cell proliferation of rat adrenal pheochromocytoma PC-12.

Description

technical field [0001] The invention relates to the technical field of traditional Chinese medicine preparations, in particular to a preparation method and application of a Qingnao Jiangya tablet. Background technique [0002] Qingnao Jiangya tablet is recorded in the standard WS3-B-0424-90 of the Ministry of Health, consisting of 100g of Scutellaria baicalensis, 60g of Prunella vulgaris, 60g of Huai Mi, 60g of calcined magnet, 60g of Achyranthes bidentata, 100g of angelica, 40g of rehmannia glutinosa, 40g of salvia miltiorrhiza, 20g of leech, Uncaria 60g, cassia seed 100g, earthworm 20g, mother-of-pearl 40g are made as raw materials, which can clear the brain and lower blood pressure. For high blood pressure, dizziness, dizziness, insomnia, forgetfulness, and memory loss. [0003] In the prior art, there is no report on the use of supercritical and microwave technology in the extraction and preparation of Qingnao Jiangya Tablets. However, the method of powdering and decoct...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/804A61K9/20A61P9/12A61P25/28A61K35/64A61K35/62A61K35/56A61K33/26A61K35/618
Inventor 不公告发明人
Owner TONGHUA YUSHENG PHARMA
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