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Carbomer gel and preparation method thereof

A carbomer gel and formula technology, applied in pharmaceutical formulas, medical preparations with inactive ingredients, sexually transmitted diseases, etc., can solve the problems of irregular bleeding, easy recurrence, and contaminated clothing, etc. Effect

Inactive Publication Date: 2013-03-27
娄飞
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Clinical treatment mostly adopts freezing, laser, microwave and other methods, but there are often a large amount of vaginal discharge and irregular bleeding after treatment, the recovery time is long, easy to be infected, and patients are not easy to accept, and the treatment of cervical erosion is mainly local medicine, especially cervical cancer For those with mild erosion or shallow inflammation, local drug therapy should be used, such as local drug film application or drug liquid rubbing, which can obtain better curative effect
Because local drug treatment needs to be carried out many times, the course of treatment is long, and must be completed by the main medical staff, therefore, patients often find it difficult to adhere to it, which affects the curative effect
There are many types of gynecological external medicines for the treatment of cervical erosion in the market, but the cure rate is low, easy to recur, pollutes clothes, and is inconvenient to use

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0017] 1. Weigh 30g of carbomer, add 500g of water for injection to soak and swell, and let stand for 12h. While stirring, 50 g of triethanolamine solution was added to adjust the pH to 6.5 to form a transparent hydrogel.

[0018] 2. Weigh 250 g of glycerin, 0.1 g of disodium edetate, and 5 g of benzyl alcohol into the transparent hydrogel for emulsification and stirring for 1 hour.

[0019] 3. Add 164.9g of water for injection and continue to stir for 20 minutes to make the solution uniform.

[0020] 4. Sampling is carried out for intermediate inspection, and filling is carried out in a 10,000-level environment after passing the test.

[0021] 5. Blister packaging after filling.

[0022] 6. Microwave sterilization and packaging are carried out after blistering.

Embodiment 2

[0024] 1. Weigh 50g of carbomer, add 500g of water for injection to soak and swell, and let stand for 10h. While stirring, 40 g of ethylenediamine solution was added to adjust the pH to 5.0 to form a transparent hydrogel.

[0025] 2. Weigh 250 g of glycerol, 0.2 g of disodium edetate, and 10 g of benzoic acid into the transparent hydrogel for emulsification and stirring for 1 hour.

[0026] 3. Add 149.8g of water for injection and continue to stir for 40 minutes to make the solution uniform.

[0027] 4. Sampling is carried out for intermediate inspection, and filling is carried out in a 10,000-level environment after passing the test.

[0028] 5. Blister packaging after filling.

[0029] 6. Microwave sterilization and packaging after blistering.

Embodiment 3

[0031] 1. Weigh 80g of carbomer, add 500g of water for injection to soak and swell, and let stand for 12h. While stirring, 35 g of sodium hydroxide solution was added to adjust the pH to 6.0 to form a transparent hydrogel.

[0032] 2. Weigh 250g of glycerin, 0.3g of sodium sulfite, and 8g of sodium benzoate into the transparent hydrogel for emulsification and stirring for 1 hour.

[0033] 3. Add 126.7g of water for injection and continue to stir for 20 minutes to make the solution uniform.

[0034] 4. Sampling is carried out for intermediate inspection, and filling is carried out in a 10,000-level environment after passing the test.

[0035] 5. Blister packaging after filling.

[0036] 6. Microwave sterilization and packaging after blistering.

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PUM

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Abstract

The invention discloses carbomer gel and a preparation method thereof, relates to a medicament for treating gynecopathy and the preparation method thereof and specifically relates to the carbomer gel and the preparation method thereof. The invention provides the carbomer gel with good efficacy and convenience in preparation and the preparation method thereof. The carbomer gel comprises the following components in percentage by weight (accounted by 100%): 3%-8% of carbomer, 3%-5% of triethanolamine, ethylenediamine or sodium hydroxide, 20%-30% of glycerol or propylene glycol, 0.5%-1% of benzyl alcohol, benzoic acid or sodium benzoate, 0.01-0.03% of ethylenediaminetetraacetic acid disodium or sodium sulfite and the balance of water.

Description

Technical field: [0001] The invention relates to a medicine for treating gynecological diseases and a preparation method thereof, more specifically, to carbomer gel and a preparation method thereof. Background technique: [0002] At present, cervical erosion is a common and frequently-occurring disease in gynecology, and it is also a high-risk factor for cervical cancer. Clinical treatment mostly adopts freezing, laser, microwave and other methods, but there are often a large amount of vaginal discharge and irregular bleeding after treatment, the recovery time is long, easy to be infected, and patients are not easy to accept, and the treatment of cervical erosion is mainly local medicine, especially cervical cancer For those with mild erosion or shallow inflammation, local drug therapy should be used, such as local drug film application or drug liquid rubbing, which can obtain better curative effect. Because local drug therapy needs to be carried out many times, the...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/78A61K9/06A61K47/32A61P15/00A61P31/12A61P37/02
Inventor 娄飞
Owner 娄飞
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