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Medicinal composition containing lysine hydrochloride compound

A technology of lysine hydrochloride and a composition, applied in the field of medicine, can solve the problems of inconvenience of use, unsatisfactory dissolution rate and the like, and achieve the effects of convenient use, rapid dissolution and good tolerance

Active Publication Date: 2014-04-16
姚云
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Some products have unsatisfactory dissolution speed during clinical use, which causes inconvenient use. This invention provides a new prescription and preparation method, so that the medicine will not turn yellow when stored for a long time, and at the same time, the dissolution speed is improved.

Method used

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  • Medicinal composition containing lysine hydrochloride compound
  • Medicinal composition containing lysine hydrochloride compound
  • Medicinal composition containing lysine hydrochloride compound

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Lysine hydrochloride 3000g;

[0054] Mannitol 150g;

[0055] Propylene glycol 1.5g

[0056] Calcium EDTA 2g;

[0057] Vitamin C 1.5g,

[0058] 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4;

[0059] Preparation

[0060] (1) Weigh the raw and auxiliary materials according to the prescription quantity

[0061] (2) Add mannitol, propylene glycol, EDTA calcium, and vitamin C to 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4, and stir to dissolve.

[0062] (3) Add the prescribed amount of lysine hydrochloride into the solution and stir to dissolve completely. Stir to combine.

[0063] (4) Measure the pH value of the solution, which is 7.0.

[0064] (5) Fine filter with a 0.2 μm microporous membrane to check the clarity of the solution.

[0065] (6) According to the measurement results, fill the liquid medicine into a vial with a volume of about 2ml.

[0066] ...

Embodiment 2

[0069] Lysine hydrochloride 3000g;

[0070] Mannitol 100g;

[0071] Propylene glycol 1.5g

[0072] Calcium EDTA 1g;

[0073] Vitamin C 1g,

[0074] 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4;

[0075] Preparation

[0076] Same as Example 1

Embodiment 3

[0078] Lysine hydrochloride 3000g;

[0079] Mannitol 200g;

[0080] Propylene glycol 1.5g

[0081] Calcium EDTA 3g;

[0082] Vitamin C 2g,

[0083] 2000ml of disodium hydrogen citrate and trisodium citrate buffer solution with a molar ratio of 1:4;

[0084] Preparation

[0085] With embodiment 1.

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Abstract

The invention relates to a medicinal composition containing a lysine hydrochloride compound, and in particular relates to freeze-dried injection of lysine hydrochloride and a preparation method thereof. Each 1,000 injections are prepared from the following components: 3,000g of lysine hydrochloride, 100 to 200g of mannitol, 1 to 3g of ethylene diamine tetraacetic acid (EDTA) calcium, 1 to 2g of vitamin C, and 2,000ml of buffer solution of disodium hydrogen citrate and trisodium citrate in a mole ratio of 1:4.

Description

technical field [0001] The invention relates to a freeze-dried powder preparation of lysine hydrochloride and a preparation method thereof, belonging to the field of medicine. Background technique [0002] Lysine, English name: lysine, is one of the essential amino acids for the human body. In recent years, scientists have discovered that lysine is the most important and essential component of somatostatin, an important substance that controls human growth. and the peripheral nervous system play an important role. The current research also shows that lysine also plays a role in the treatment of craniocerebral trauma, chronic brain tissue ischemia, and hypoxic diseases. Its chemical structure is as follows: [0003] [0004] Lysine hydrochloride injections that have been on the market include freeze-dried powder injections. Because lysine hydrochloride is easily soluble in water, only mannitol is generally used as a filler in its formula. The problem of yellowing require...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K9/19A61K31/198A61K47/22A61P25/00
Inventor 姚云
Owner 姚云
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