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Traditional Chinese medicine multicomponent micro-emulsion composition having function of resisting lung cancer, preparation method and application thereof in preparation of orally-taking lung cancer resistant medicine

A multi-component, anti-lung cancer technology, applied in the direction of drug combinations, medical preparations containing active ingredients, anti-tumor drugs, etc., can solve problems that have not been seen before, and achieve simple preparation process, good industrialization prospects, and easy industrialization Effect

Active Publication Date: 2013-03-13
陈彦
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, there are no reports of preparations combining the above four types of components in Ganoderma lucidum and Coix Seed through literature and patent searches.

Method used

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  • Traditional Chinese medicine multicomponent micro-emulsion composition having function of resisting lung cancer, preparation method and application thereof in preparation of orally-taking lung cancer resistant medicine
  • Traditional Chinese medicine multicomponent micro-emulsion composition having function of resisting lung cancer, preparation method and application thereof in preparation of orally-taking lung cancer resistant medicine

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0057] Prescription: Ganoderma lucidum total triterpenoids 4.5g, Coixenolide 24g, Ganoderma lucidum polysaccharide 5.4g, Coix seed polysaccharide 23.4g, polyoxyethylene hydrogenated castor oil 24g, polyethylene glycol 400 12g, distilled water 156g.

[0058] Accurately weigh Ganoderma lucidum polysaccharide and coix seed polysaccharide according to the prescription quantity, dissolve in the distilled water of the prescription quantity, prepare water phase, and set aside;

[0059] Take another container, accurately weigh the total triterpenes of Ganoderma lucidum according to the prescription ratio, put it in the container, add coixenolide, mix well under a magnetic stirrer to dissolve the drug, and then add the prescribed amount of polyoxyethylene hydrogenated castor oil, polyethylene glycol Alcohol 400, mixed under a magnetic stirrer; using the prepared water phase, the microemulsion nano composition was prepared by water titration.

Embodiment 2

[0061] Prescription: Ganoderma lucidum total triterpenes 4.5g, Coixenolide 27g, Ganoderma lucidum polysaccharide 6g, Coix seed polysaccharide 9g, poloxamer 30g, isopropanol 15g, distilled water 180g.

[0062] The preparation method is the same as in Example 1.

Embodiment 3

[0064] Prescription: Ganoderma lucidum total triterpenes 4.5g, Coixenolide 24g, Ganoderma lucidum polysaccharide 5.4g, Coix seed polysaccharide 19.5g, Tween 80 24g, ethanol 12g, distilled water 165g.

[0065] The preparation method is the same as in Example 1.

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Abstract

The invention discloses a traditional Chinese medicine multicomponent micro-emulsion composition having a function of resisting lung cancer, a preparation method and application thereof in preparation of an orally-taking lung cancer resistant medicine. The application comprises the following steps of: adding ganoderma lucidum total triterpenes, coixenolide, ganoderan and semen coicis polysaccharide used as raw material medicines into a nano-medicine composition which consists of surfactants and cosurfactant, wherein the traditional Chinese medicine multicomponent micro-emulsion composition comprises the following components in parts by weight: 5-30 parts of ganoderma lucidum total triterpenes, 45-150 parts of coixenolide, 5-50 parts of ganoderan and 10-90 parts of semen coicis polysaccharide, 45-200 parts of surfactants, 20-100 parts of cosurfactant and 300-900 parts of distilled water. The invention also discloses a preparation method of the composition. The ganoderma lucidum total triterpenes and the coixenolide are carried into a non-water phase, and the lucid ganoderma and the semen coicis polysaccharide are carried into a water phase, so that the coixendide can be used as medicines and also can be used as an auxiliary; the polysaccharide can enhance the immunization and the stability of a micro-emulsion system; and by the micro-emulsion, the absorption of the ganoderma lucidum total triterpenes and coixenolide used as the lipid solubility components can be increased, and the matching of four components have a synergy anti-tumor effect so as to increase the anti-tumor effect.

Description

[0001] technical field [0002] The invention relates to a multi-component anti-lung cancer microemulsion of traditional Chinese medicine. In the nano composition, the water-insoluble drugs Ganoderma lucidum triterpenoids and Coixenolide are loaded into the non-aqueous phase, and Ganoderma lucidum polysaccharides and Coix seed polysaccharides are loaded into the water phase. Prepare a multi-component microemulsion composition. The present invention also relates to the preparation method of this microemulsion composition. Background technique [0003] Lung cancer is currently the number one cancer killer in the world. There are 1.2 million new cases of lung cancer every year in the world, and one person dies of lung cancer every 30 seconds. In my country, lung cancer is also the cancer with the highest morbidity and mortality. It is predicted that by 2025, there will be more than 1 million lung cancer patients in my country every year, becoming the world's largest lung cance...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/074A61K9/107A61P35/00A61K31/715A61K31/22
Inventor 陈彦贺俊杰
Owner 陈彦
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