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Use of resveratrol or another hydroxylated stilbene for preserving cognitive functioning

A technology of stilbene and hydroxylation, which is applied in the direction of active ingredients of hydroxyl compounds, functions and applications of food ingredients, etc.

Inactive Publication Date: 2013-03-06
NUTRICIA
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Effects on microvessels in the brain have not been reported

Method used

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  • Use of resveratrol or another hydroxylated stilbene for preserving cognitive functioning
  • Use of resveratrol or another hydroxylated stilbene for preserving cognitive functioning
  • Use of resveratrol or another hydroxylated stilbene for preserving cognitive functioning

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Experimental program
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Embodiment Construction

[0023] In the context of the present invention, the term "nutraceutical" as used herein refers to the use in the field of nutritional and pharmaceutical applications. Therefore, it has been found that the nutritional supplement composition containing hydroxylated stilbene can be used as a supplement for food and beverages, and as a pharmaceutical formulation for enteral or parenteral application, which can be a solid such as a capsule or a tablet. Formulations, or liquid formulations such as solutions or suspensions. From the above description, it is obvious that the term nutritional supplement composition also includes nutritional compositions containing the above-mentioned specific active ingredients, for example, nutritional bars, biscuits, drinks, yogurt, ice cream, beverages and the like.

[0024] Hydroxylated stilbene

[0025] The term hydroxylated stilbene as used herein includes compounds encompassed by general formula I

[0026]

[0027] Formula I

[0028] Where A represent...

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Abstract

The present invention relates to the use of an hydroxylated stilbene, in particular resveratrol, in the manufacture of a neutraceutical composition for increasing the mi- crovascular plasticity and / or microvessel density, and / or decreasing the microvessel abnormalities in the brain, in particular in the hippocampus of a mammal, in particular for the treatment of age- and condition-related decline in brain neuronal function and / or cognitive functioning in a mammal. In particular, the condition is selected from the group of Alzheimer's Disease, dementia, depression, sleep disorders, impaired memory function, psychoses, Parkinson's disease, Huntington's chorea, epilepsy, schizophrenia, paranoia, ADHD and anxiety.

Description

Technical field [0001] The present invention relates to the use of hydroxylated stilbene in the manufacture of nutritional supplement composition for increasing microvascular plasticity (plasticity, flexibility) and / or microvascular density in the brain, and / or reducing brain Abnormal blood vessels in the brain, and / or improve the distribution of blood in the mammalian brain, especially the hippocampus, and / or increase blood supply, and / or improve the nutrient supply to brain cells, and / or improve the oxygen supply to brain cells And / or improve the clearance of metabolites from mammalian brain tissue. Background technique [0002] Resveratrol (3,5,4'-trihydroxystilbene) is a natural polyphenol substance rich in grapes and red wine, and has potential beneficial effects on human health. In fact, the lower incidence of cardiovascular disease in countries that drink red wine with high saturated fat content in the diet is a phenomenon called "French paradox", which is usually related...

Claims

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Application Information

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IPC IPC(8): A61K31/05A23L1/30A61P25/00A61P25/28
CPCA23V2002/00A61K31/05A23L1/301A23L2/52A23L1/3002A23L33/105A23L33/127A61P25/00A61P25/08A61P25/16A61P25/18A61P25/22A61P25/24A61P25/28A61P9/00A23V2250/54246A23V2250/54252A23V2250/5114A23V2250/2132A23V2200/322
Inventor 埃利娜·马伦·范德贝克马蒂厄斯·科内利斯·德维尔德马丁·格罗宁戴克帕特里克·约瑟夫·赫拉尔杜斯·亨德里库斯·坎普乌斯
Owner NUTRICIA
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