In-situ hemostatic containing desmopressin
A desmopressin and drug technology, which is applied in the directions of medical preparations containing active ingredients, drug combinations, pharmaceutical sciences, etc., can solve the problems such as the lack of aminopressin, and achieve the effect of obvious hemostatic effect.
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Embodiment 1
[0019] Chitosan 50g
[0020] water 1000ml
[0021] Desmopressin 500 micrograms
[0022] Mix the cross-linked chitosan with 800 milliliters of water, heat to dissolve, add 200 milliliters of water containing 500 micrograms of desmopressin after cooling, fully stir, and place in a suitable mold. Pre-freeze at -40 for 5 hours and freeze-dry for 24 hours to obtain desmopressin chitosan sponge hemostatic agent.
Embodiment 2
[0024] Dextrin 50g
[0025] water 200ml
[0026] Desmopressin 500 micrograms
[0027] The dextrin is firstly cross-linked into microspheres, and the particle size is controlled at 50-100 mesh. Fully mix 50 grams of dextrin with 200 milliliters of an aqueous solution containing 500 micrograms of desmopressin, stir for two hours, drain the water, and dry in a vacuum oven at 30 degrees for 36 hours until the water content is below 5%. Sterilize. That is, the dextrin powder of desmopressin is obtained.
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