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Cefotaxime sodium and tazobactam sodium preparation for injection and preparing method thereof

A technology of tazobactam sodium and cefotaxime sodium, applied in the field of medicine, can solve problems such as discoloration and poor content uniformity, achieve good sterilization effect, avoid uneven mixing, and simple operation process

Active Publication Date: 2013-03-06
HAINAN HULUWA PHARMA GRP CO LTD
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

In the preparation method of the compound preparation disclosed in this application, tazobactam sodium is a freeze-dried powder when mixed, and in actual production, direct mixing will cause stratification, resulting in a final product with poor content uniformity and discoloration after a period of storage

Method used

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  • Cefotaxime sodium and tazobactam sodium preparation for injection and preparing method thereof
  • Cefotaxime sodium and tazobactam sodium preparation for injection and preparing method thereof
  • Cefotaxime sodium and tazobactam sodium preparation for injection and preparing method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0033] Preparation of cefotaxime sodium and tazobactam sodium preparations for injection

[0034] The mass ratio of cefotaxime sodium to tazobactam sodium is 3.9:1.

[0035] Put 279.5g of cefotaxime sodium in the mixer and mix for 10 minutes, add 107.3g of newly prepared lyophilized powder of tazobactam sodium, mix for 5 minutes while passing compressed air, then add 559g of cefotaxime sodium and mix for 10 minutes , add 107.3g freshly prepared lyophilized powder of tazobactam sodium, mix for 5 minutes while feeding compressed air, discharge, sub-package to prepare cefotaxime sodium for injection and tazobactam sodium preparations.

Embodiment 2

[0037] Preparation of cefotaxime sodium and tazobactam sodium preparations for injection

[0038] The mass ratio of cefotaxime sodium to tazobactam sodium is 3.95:1.

[0039] Put 279.5g of cefotaxime sodium in the mixer and mix for 10 minutes, add 106.2g of freshly prepared lyophilized powder of tazobactam sodium, mix for 5 minutes while passing compressed air, then add 559g of cefotaxime sodium and mix for 10 minutes , add 106.2g freshly prepared lyophilized powder of tazobactam sodium, mix for 5 minutes while feeding compressed air, discharge, sub-package to prepare cefotaxime sodium for injection and tazobactam sodium preparations.

Embodiment 3

[0041] Preparation of cefotaxime sodium and tazobactam sodium preparations for injection

[0042] The mass ratio of cefotaxime sodium to tazobactam sodium is 3.98:1.

[0043] Put 279.5g of cefotaxime sodium in the mixer and mix for 10 minutes, add 105.3g of newly prepared lyophilized powder of tazobactam sodium, mix for 5 minutes while passing compressed air, then add 559g of cefotaxime sodium and mix for 10 minutes , add 105.3g freshly prepared lyophilized powder of tazobactam sodium, mix for 5 minutes while feeding compressed air, discharge, sub-package to prepare cefotaxime sodium for injection and tazobactam sodium preparations.

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Abstract

The invention discloses a cefotaxime sodium and tazobactam sodium preparation for injection and a preparing method thereof. The preparing method comprises the step that cefotaxime sodium and tazobactam sodium are mixed uniformly to prepare the cefotaxime sodium and tazobactam sodium preparation for injection, wherein the mass ratio of the cefotaxime sodium to the tazobactam sodium is 1-4:1. A product prepared throughin the preparing method has good uniformity, the operation is simple, no special devices are needed in the production, and the method is suitable for industrial production. The cefotaxime sodium and tazobactam sodium preparation for injection has good content uniformity and stable quality.

Description

technical field [0001] The invention relates to the technical field of medicine, in particular to a preparation of cefotaxime sodium and tazobactam sodium for injection and a preparation method thereof. Background technique [0002] Cefotaxime sodium is (6R,7R)-3-[(acetoxy)methyl]-7-[(2-amino-4-thiazolyl)-(methoxyimino)acetamido]-8-oxo Generation-5-thia-1-azabicyclo[4.2.0]oct-2-ene-2-carboxylic acid sodium salt. Molecular formula C 16 h 16 N 5 NaO 7 S 2 , Molecular weight: 477.45, the chemical structural formula is as follows: [0003] [0004] Cefotaxime sodium is a third-generation cephalosporin with broad-spectrum antibacterial effect. The drug is suitable for pneumonia and other lower respiratory tract infections, urinary tract infections, meningitis, sepsis, abdominal infections, pelvic infections, skin Soft tissue infection, reproductive tract infection, bone and joint infection, etc. Cefotaxime sodium can be used as the drug of choice for infantile meningit...

Claims

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Application Information

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IPC IPC(8): A61K31/546A61K31/431A61P31/04
Inventor 刘全国陈克领
Owner HAINAN HULUWA PHARMA GRP CO LTD
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