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Composite calcium carbonate/vitamin D3 granules for children and preparation method thereof

A compound calcium carbonate and vitamin technology, applied in the direction of aluminum/calcium/magnesium active ingredients, non-active ingredient medical preparations, medical preparations containing active ingredients, etc., can solve poor absorption, inconvenient taking, calcium carbonate blisters Eliminate the discomfort of the taste of Teng granules, etc., and achieve the effect of easy preparation, easy acceptance, and high dissolution rate

Active Publication Date: 2013-02-06
北京朗迪制药有限公司
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0008] However, the above-mentioned calcium carbonate effervescent granules have defects such as still uncomfortable mouthfeel, foaming, inconvenience in taking and poor absorption, etc.

Method used

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  • Composite calcium carbonate/vitamin D3 granules for children and preparation method thereof
  • Composite calcium carbonate/vitamin D3 granules for children and preparation method thereof
  • Composite calcium carbonate/vitamin D3 granules for children and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] 1. Prescription 1

[0066] Specification (500mg)

[0067]

[0068] 2. Preparation method: Take respectively 125.0g of calcium carbonate, 145.0g of microcrystalline cellulose, and 30.0g of sucrose in the prescribed quantities, and pass through a 100-mesh sieve to mix them evenly. Take 0.5mg vitamin D 3 Add absolute ethanol to dissolve, and make a solution with a concentration of about 50 μg / ml. Add the above solution to the fine powder of raw materials and auxiliary materials, mix well, and add an appropriate amount of 30% ethanol to make a soft material. Press the soft material through a 14-mesh sieve to make granules. After the wet granules are made, put them into an oven to dry at 70°C immediately, take them out after drying, and sieve. The results of testing this prescription sample are shown in Table 1.

[0069] Table 1 Determination results of prescription 1

[0070]

Embodiment 2

[0072] 1. Prescription 2

[0073] Specification (500mg)

[0074]

[0075] 2. Preparation method: Take respectively 125.0g of calcium carbonate, 130.0g of lactose, and 45.0g of sucrose in the prescribed quantities, and pass through a 100-mesh sieve to mix them evenly. Take 0.5 mg of vitamin D3 and add absolute ethanol to dissolve it to make a solution with a concentration of about 50 μg / ml. Add the above solution to the fine powder of raw materials and auxiliary materials, mix well, and add an appropriate amount of 30% ethanol to make a soft material. Press the soft material through a 14-mesh sieve to make granules. After the wet granules are made, put them into an oven to dry at 70°C immediately, take them out after drying, and sieve. The results of testing this prescription sample are shown in Table 2.

[0076] Table 2 Determination results of prescription 2

[0077]

Embodiment 3

[0079] 1. Prescription 3

[0080] Specification (500mg)

[0081]

[0082] 2. Preparation method: Weigh 125.0g of calcium carbonate, 75.0g of sucrose, and 100.0g of mannitol, respectively, and pass through a 100-mesh sieve to mix them evenly. Take 0.5 mg of vitamin D3 and add absolute ethanol to dissolve it to make a solution with a concentration of about 50 μg / ml. Add the above solution to the fine powder of raw materials and auxiliary materials, mix well, and add an appropriate amount of 30% ethanol to make a soft material. Press the soft material through a 14-mesh sieve to make granules. After the wet granules are made, put them into an oven to dry at 70°C immediately, take them out after drying, and sieve. The results of testing this prescription sample are shown in Table 3.

[0083] Table 3 Determination results of prescription 3

[0084]

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PUM

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Abstract

The invention relates to composite calcium carbonate / vitamin D3 granules for children prepared from the raw materials, such as calcium carbonate / vitamin D3 and an adjuvant. The preparation is granules, each bag contains 1,250mg of calcium carbonate and vitamin D3 with an international unit of 200, and the adjuvant is selected from a diluent, a bonding agent, a wetting agent and a flavoring agent. The invention also relates to a preparation method of the composite calcium carbonate / vitamin D3 granules for children, a prescription and a preparation technology are feasible, so that the grannles are suitable for mass production; and the prepared composite calcium carbonate / vitamin D3 granules are good in granulation property, and have better degree of homogeneity and higher dissolution rate. The composite calcium carbonate / vitamin D3 granules for children disclosed by the invention are suitable for children, old people and the persons who have swallowing difficulties, especially suitable for children.

Description

technical field [0001] The invention belongs to the field of pharmaceutical preparations, in particular to a compound calcium carbonate / vitamin D3 granule for children and a preparation method thereof. Background technique [0002] Calcium deficiency in children can cause a variety of diseases. Rickets, for example, is one of them. Rickets is commonly known as calcium deficiency and is more common in infancy. It is a disease in which vitamin D deficiency causes calcium and phosphorus metabolism disorders in the body, resulting in poor bone calcification. The onset of rickets is slow, and it is not easy to attract attention. Rickets lowers children's resistance, and is easy to be combined with diseases such as pneumonia and diarrhea, which affects children's growth and development. Even though the current living standard has improved a lot, the incidence of rickets is still very high. According to reports, in the south, the rate of rickets in infants under 1 year old is 20-...

Claims

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Application Information

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IPC IPC(8): A61K33/10A61K9/16A61K47/38A61K47/40A61K47/36A61K47/32A61P3/02A61P19/08A61K31/593
Inventor 李细海
Owner 北京朗迪制药有限公司
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