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Compound and preparation method and application thereof

A compound and preparation method technology, applied in the fields of medicine, health and food chemical industry

Active Publication Date: 2013-01-30
林翔 +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, so far, a new compound of texiic acid derivatives has not been found

Method used

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  • Compound and preparation method and application thereof
  • Compound and preparation method and application thereof
  • Compound and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0053] Preparation of Gallinadin A and Gallinadin B

[0054] Take 500g of (feather) chicken bone grass leaves, add 50% ethanol to reflux extraction twice, combine the extracts, recover under reduced pressure until there is no alcohol smell or a moderate amount, and centrifugally filter to obtain the supernatant A. The supernatant A is loaded on the treated polyamide or macroporous resin column for adsorption, then eluted with deionized water, 50% ethanol by volume, and 95% ethanol by volume, and the 95% ethanol is collected The eluate was evaporated to dryness under reduced pressure, the residue was dissolved with a small amount of water, and the 18 Reverse-phase silica gel chromatography column, carry out gradient chromatography separation with methanol aqueous solution with volume ratio concentration of 10%, 20%, 30%, 40%, 50%, 60%, 80%, 100%, collect each separation liquid, reduce Recycled to dryness, the residue was dissolved with an appropriate amount of water and methan...

Embodiment 2

[0056] Preparation of Gallinadin A and Gallinadin B

[0057] Take 500g of (feather) chicken bone grass leaves, add water or 95% ethanol to reflux twice, combine the extracts, recover to an appropriate amount under reduced pressure, add an appropriate amount of ethanol or water until the alcohol content is 50% for precipitation treatment, concentrate to an appropriate amount, and obtain concentrated Liquid B. Load the concentrated solution B on the treated polyamide or macroporous resin column for adsorption, then elute with water, ethanol with a concentration of 50% by volume, and ammonia solution at pH 10, collect the eluate with ammonia solution at pH 10, and evaporate to dryness under reduced pressure , the residue was dissolved with a small amount of water, on C 18 Reverse-phase silica gel chromatography column, carry out gradient chromatography separation with methanol aqueous solution with volume ratio concentration of 10%, 20%, 30%, 40%, 50%, 60%, 80%, 100%, collect ea...

Embodiment 3

[0059] Preparation of Gallinadin A and Gallinadin B

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PUM

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Abstract

The invention discloses a compound. The molecular formula of the compound is C36H34N2O10, the molecular weight is 654, and the structure formula of the compound is shown in the specifications. The invention further discloses a preparation method of the compound. In the compound, abrus cantoniensis hance oridonin and abrus cantoniensis hance ponicidin have remarkable effects of protecting liver, resisting inflammation and easing pain, and be taken as active ingredients for preparing medicaments, food additives and health-care products for preventing and treating acute and chronic hepatitis, cholecystitis, gastritis, pain and relevant diseases, and can be applied to prevention and treatment of acute and chronic hepatitis, cholecystitis, gastritis, pain and relevant diseases.

Description

【Technical field】 [0001] The invention belongs to the fields of medicine, hygiene and food chemical industry, and specifically relates to a compound which has liver-protecting, anti-inflammatory and analgesic effects and can be used for the prevention and treatment of acute and chronic hepatitis, cholecystitis, gastritis, pain and related diseases and its preparation. law and use. 【Background technique】 [0002] The liver is a detoxification organ and an important metabolic site in animals. Affected by environmental pollution, living habits and drugs, liver disease has become one of the common infectious diseases and frequently-occurring diseases that seriously endanger human health. Liver damage caused by various harmful factors can be manifested as liver necrosis, fatty liver, and cholestasis. , liver fibrosis, etc. According to its etiology, it can be divided into viral hepatitis, autoimmune hepatitis, alcoholic hepatitis, non-alcoholic fatty liver, drug-induced hepatit...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): C07C235/40C07C231/24A61K31/195A61P29/00A61P1/16A61P1/04A61P11/00A61P11/02A61P19/02A61P25/06A23F3/34A23L1/30A23L1/302A23L33/15
Inventor 袁旭江林励
Owner 林翔
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