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Effervescent tablet type low molecular weight collagen peptide and preparation method thereof

A technology of collagen peptide and low molecular weight, which is applied in the field of effervescent tablet low molecular weight collagen peptide and its preparation, can solve the problems of low yield and wide distribution range of collagen peptide, and achieve simple production process and high raw material utilization rate High, production cost reduction effect

Inactive Publication Date: 2014-06-04
TIANJIN UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It not only solves the problem of high-molecular collagen contained in cosmetics that is difficult for the human body to absorb in the prior art, but also solves the problem of wide distribution and low yield of collagen peptides in industrial production; at the same time, it is the first to create collagen that does not contain preservatives New formulations of cosmetics

Method used

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  • Effervescent tablet type low molecular weight collagen peptide and preparation method thereof
  • Effervescent tablet type low molecular weight collagen peptide and preparation method thereof
  • Effervescent tablet type low molecular weight collagen peptide and preparation method thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0036] (1) Remove non-collagenous protein in pigskin:

[0037] Select 500g of freshly chopped pigskin, wash it, drain it, soak it in 0.15mol / l NaOH solution with a volume of 15L at 25°C at room temperature, and stir it at 200 rpm for 18h to remove the non-collagenous protein in the pigskin. Then filter to get the pigskin for later use.

[0038] ⑵Removal of fat in pigskin:

[0039] Put the pigskin treated in step (1) into 15L of clear water, and use Na 2 CO 3The powder was used to adjust the pH of the water to 9, then 2.5 g of lipase was added, and the mixture was stirred at a constant temperature of 35°C and 200 rpm for 10 hours. Then filter, wash the pigskin with water and set aside.

[0040] ⑶ Sol:

[0041] The pigskin washed in step (2) was placed in 10L of distilled water, kept at a constant temperature of 80°C, and stirred at a low speed of 200 rpm for 5 hours to obtain a mixture of pigskin and water-soluble collagen.

[0042] ⑷Preparation of trypsin hydrolyzed prot...

Embodiment 2

[0051] (1) Remove non-collagenous protein in pigskin:

[0052] Select 500g of fresh pigskin, wash it, drain it, soak it in 0.1mol / l NaOH solution with a volume of 15L at room temperature at 20°C, and stir it at a low speed of 100 rpm for 20 hours to remove the non-collagenous protein in the pigskin. Then filter to get the pigskin for later use.

[0053] ⑵Removal of fat in pigskin:

[0054] Put the pigskin treated in step (1) into 15L of clear water, and use Na 2 CO 3 Adjust the pH value of the water to 9.3 with the powder, then add 5 g of lipase, and stir at a constant temperature of 35° C. at a low speed of 100 rpm for 10 hours. Then filter, wash the pigskin with water and set aside.

[0055] ⑶ Sol:

[0056] The pigskin washed in step (2) was placed in 10L of distilled water, kept at a constant temperature of 80°C, and stirred at a low speed of 100 rpm for 6 hours to obtain a mixture of pigskin and water-soluble collagen.

[0057] ⑷Preparation of trypsin hydrolyzed prot...

Embodiment 3

[0066] (1) Remove non-collagenous protein in pigskin:

[0067] Select 500g of fresh pigskin, wash it, drain it, soak it in 0.1mol / l NaOH solution with a volume of 15L at room temperature at 20°C, and stir it at a low speed of 150 rpm for 24 hours to remove non-collagenous protein in the pigskin. Then filter to get the pigskin for later use.

[0068] ⑵Removal of fat in pigskin:

[0069] Put the pigskin treated in step (1) into 15L of clear water, and use Na 2 CO 3 Use the powder to adjust the pH of the water to 9.2, then add 5 g of lipase, and stir at a constant temperature of 35° C. at a low speed of 150 rpm for 10 hours. Then filter, wash the pigskin with water and set aside.

[0070] ⑶ Sol:

[0071] The pigskin washed in step (2) was placed in 10 L of distilled water, kept at a constant temperature of 80°C, and stirred at a low speed of 150 rpm for 6 hours to obtain a mixture of pigskin and water-soluble collagen.

[0072] ⑷Preparation of trypsin hydrolyzed protein pep...

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Abstract

The invention discloses effervescent tablet type low molecular weight collagen peptide and a preparation method of the effervescent tablet type low molecular weight collagen peptide. The preparation method comprises main steps of removing noncollagenous protein, degreasing by virtue of biological enzyme, soling, implementing enzymolysis by virtue trypsin, jointly discoloring by virtue of kieselguhr and macroporous resin, concentrating and drying, mixing with various beneficial raw materials, and pressing to obtain the effervescent tablets. With the adoption of the preparation method disclosed by the invention, the technical conditions for soling and enzymolysis are optimized based on conventional technology, so that the collagen peptide with molecular weight centrally distributed within the range from 500 to 1600Da is obtained, the follow-up technological operation is simplified, and the producing cost is reduced; the way of jointly discoloring the collagen peptide liquid by virtue of the kieselguhr and macroporous resin is first provided; and with the implementation of the way, good discoloring effect is obtained, and little collagen peptide is lost. In aspect of preparation, the effervescent tablets which are capable of beautifying and moisturizing and high in permeation of skin are adopted; and any preservatives are not added, so that the cosmetic is safe and beneficial for human skin.

Description

technical field [0001] The invention relates to the field of collagen peptide extraction and application, and more specifically relates to an effervescent tablet-type low-molecular-weight collagen peptide and a preparation method thereof. Background technique [0002] Collagen or collagen is a biopolymer compound synthesized by animal cells (from sponges to vertebrates), widely present in animal bones, tendons, cartilage, skin and other connective tissues, accounting for about 1 of the total mammalian proteins / 3, more than 90% of the protein in bones and tendons, and more than 50% of the protein in the skin is collagen. Collagen peptide, the hydrolyzed product of collagen, has many functions such as anti-blood pressure, immune regulation, anti-tumor, skin care and beauty. Collagen active peptides produced by protein hydrolysis are mainly obtained by chemical and enzymatic hydrolysis. Chemical methods use acid or alkali to break protein peptide bonds. Due to the extreme rea...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): C12P21/06C07K4/12C07K1/36C07K1/34C07K1/18A61K8/97A61K8/65A61K8/02A61Q19/00
Inventor 朱宏吉张华王世鹏滕欣余路明月姜珊方洁张鑫
Owner TIANJIN UNIV
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