Portable noninvasive real-time photoacoustic viscoelastic detector

Abstract

The invention relates to a portable noninvasive real-time photoacoustic viscoelastic detector which comprises a semiconductor laser, an electrooptical modulator, a function generator, a measuring box, a focusing lens, a rectangular prism group, an ultrasonic transducer, a preposed signal amplifier, a lock-in amplifier and a data acquisition device; along the laser propagation direction, the semiconductor laser, the electrooptical modulator, and the measuring box are orderly arranged; in the measuring box, a laser inlet, the focusing lens, the rectangular prism group, and a laser outlet are arranged in a line; in the measuring box, along the acoustic wave propagation direction, the laser outlet, the rectangular prism group, and the ultrasonic transducer are orderly arranged; the ultrasonic transducer, the preposed signal amplifier, the lock-in amplifier and the data acquisition device are orderly connected electrically; the function generator is respectively connected with the electrooptical modulator and the lock-in amplifier. The invention has the advantages of simple structure, higher measurement precision and sensitivity, and convenient operation, and belongs to the technical field of biomedical detection.

Description

technical field [0001] The invention relates to biomedical detection technology, in particular to a portable non-invasive, real-time photoacoustic viscoelastic detector. Background technique [0002] For a long time, palpation has been an indispensable means for doctors in clinical diagnosis. Through palpation of soft tissue, changes in the texture and viscoelasticity of the tissue can be sensed, thereby judging whether the tissue is normal or not. Especially for the exploration of tumor tissue, the texture, activity, and relationship with the surrounding area are often sensed by palpation to infer the benign and malignant tumors. It is generally believed that the change of soft tissue texture is closely related to its pathological process. From a biomechanical point of view, the change of soft tissue texture means the change of its mechanical properties, that is to say, when the tissue is diseased, the viscoelastic characteristics of the tissue will change accordingly. T...

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Problems solved by technology

However, in the above method, the photoacoustic excitation and the reception of the acoustic signal fail to achieve a coaxial confocal structure, so the efficiency of photoacoustic excitation and detection is not high, which reduces the accuracy of the measurement results

Moreover, the above method is in the opposite detection mode, which lacks the convenience of practical operation, and is not conducive to the viscoelasticity measurement of in vivo tissue, and the actual popularization and application have received great restrictions.

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