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Traditional Chinese medicine extract of total saponin ingredients and preparation method of same

A technology of extracts and total saponins, which is applied in the field of traditional Chinese medicine extracts of total saponins and its preparation, can solve the problems of few applications, and achieve the effects of low cost, improvement of symptoms, and convenient preparation methods

Inactive Publication Date: 2013-01-16
BAOTOU CHINESE TRADITIONAL MEDICINE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Macroporous separation technology is widely used in domestic extract production enterprises, but rarely used in the production of Chinese patent medicines

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0022] (1) Respectively remove impurities from Lily and Anemarrhena, wash, and dry at a low temperature of 50-60°C;

[0023] (2) After mixing Lily and Anemarrhena, soak overnight at 50°C with 2 times the amount of 70% ethanol, and start percolation. Add 3 times of water for diafiltration, and collect the aqueous solution as B.

[0024] (3) Recover ethanol from A to obtain a concentrated liquid C with a weight of 1:1 medicinal material, and mix B and C.

[0025] (4) Filtration (ceramic membrane) or microfiltration.

[0026] (5) Adsorb on the PlPl01 resin column at a speed of 2ml / min.

[0027] (6) Wash with 10 times the column volume of purified water, backwash with 4 times the column volume of 70% ethanol, recover the 70% ethanol solution, concentrate, and dry.

[0028] (7) The dry matter is crushed and passed through a 100-mesh sieve.

Embodiment 2

[0030] (1) Remove impurities from Lily and Anemarrhena, wash and dry at 60-70°C;

[0031] (2) After mixing Lily and Anemarrhena, soak overnight at 50°C with 4 times the amount of 70% ethanol, and start percolation. Add 5 times of water for diafiltration, and collect the aqueous solution as B.

[0032] (3) Recover ethanol from A to obtain a concentrated liquid C with a weight of 1:1 medicinal material, and mix B and C.

[0033] (4) Filtration (ceramic membrane) or microfiltration.

[0034] (5) Adsorb on the PlPl01 resin column at a speed of 3ml / min.

[0035] (6) Wash with purified water for 8 times the column volume, backwash with 70% ethanol for 5 times the column volume, recover the 70% ethanol solution, concentrate, and dry.

[0036] (7) The dry matter is crushed and passed through a 100-mesh sieve.

Embodiment 3

[0038] (1) Respectively remove impurities from Lily and Anemarrhena, wash, and dry at a low temperature of 50-70°C;

[0039] (2) After mixing Lily and Anemarrhena, soak overnight at 50°C with 3 times the amount of 70% ethanol, and start percolation. Add 3 times of water for diafiltration, and collect the aqueous solution as B.

[0040] (3) Recover ethanol from A to obtain a concentrated liquid C with a weight of 1:1 medicinal material, and mix B and C.

[0041] (4) Filtration (ceramic membrane) or microfiltration.

[0042] (5) Adsorb on the PlPl01 resin column at a speed of 2ml / min.

[0043] (6) Wash with 10 times the column volume of purified water, backwash with 5 times the column volume of 70% ethanol, recover the 70% ethanol solution, concentrate, and dry.

[0044] (7) The dry matter is crushed and passed through an 80-mesh sieve.

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PUM

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Abstract

The invention relates to a traditional Chinese medicine (TCM) extract of total saponin ingredients and a preparation method of same. Raw materials for extracting the extract are 10-90 percent of lily and 10-90 percent of rhizoma anemarrhenae. All components are produced by adopting the following steps: purifying lily and rhizoma anemarrhenae, cleaning and then drying at low temperature of 50-70 DEG C; soaking lily and rhizoma anemarrhenae in alcohol, infiltering the alcohol and collecting alcohol liquor as A; adding water in residue for infiltration and collecting water solution as B; reclaiming A to alcohol to obtain a concentrated solution C with the herb weight of 1:1, and mixing B and C; filtering (a ceramic membrane) or micro-filtering; loading a P1P101 resin column at the speed of 2-3 ml / min for adsorption; and washing, backwashing with alcohol, concentrating, drying, crushing and screening. The invention has the advantages that as the extract contains saponin, a research shows that the extract can play a role of improving the symptom of a chronic stress induced depression model rat and can be used for curing human depression; and the preparation method is convenient, the cost is low, the implementation is easy, deficiencies in the prior art are made up, and a broad way is provided for development of the medicine industry.

Description

1. Technical field [0001] The invention belongs to the field of traditional Chinese medicines, and in particular relates to a traditional Chinese medicine extract of total saponins and a preparation method thereof. 2. Technical background [0002] Chinese medicine extract is a new type of traditional Chinese medicine product of modern pharmaceutical technology, and has a broad market space. The extract is the carrier of modern herbal medicine and a new product form in the international natural medicine and health care products market. This kind of product is produced under the requirements of GAP and GMP, and adopts advanced technology and testing technology at the same time. Macropore separation technology is widely used in domestic extract production enterprises, but it is rarely used in the production of Chinese patent medicines. 3. Contents of the invention [0003] The object of the present invention is to provide a kind of Chinese medicine extract and its preparati...

Claims

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Application Information

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IPC IPC(8): A61K36/8967A61P25/24
Inventor 李卫民贾金良杨丽
Owner BAOTOU CHINESE TRADITIONAL MEDICINE
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