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Cyrtomium fortunei extract and preparation method and application thereof

A technology of extracts and Guanzhong, which is applied in the field of extracts of traditional Chinese medicine, can solve the problems of anti-cancer and antioxidant effects of Guanzhong extracts that have not yet been discovered

Inactive Publication Date: 2013-01-09
GUIZHOU UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in the existing traditional Chinese medicine materials, no records and reports have been found that the extracts of Guanzhong are used to treat cancer or have anti-cancer and anti-oxidation effects.

Method used

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  • Cyrtomium fortunei extract and preparation method and application thereof
  • Cyrtomium fortunei extract and preparation method and application thereof
  • Cyrtomium fortunei extract and preparation method and application thereof

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0032] After weighing 15 kilograms of dry tubers and pulverizing them, add 2-3 times the raw materials and 80% ethanol aqueous solution of the total amount and heat and reflux for extraction. The first reflux extraction is 6 hours, the second reflux extraction is 3 hours, and the third time is reflux extraction. Reflux extraction for 1 hour, and then combine three ethanol extracts. The three combined ethanol extracts were distilled under reduced pressure, and the ethanol solution was recovered to obtain the total ethanol extract extract.

Embodiment 2

[0034] The ethanol extract was dispersed in water, and extracted three times with 10 liters of petroleum ether, ethyl acetate and n-butanol at a time. Ethyl acetate and n-butanol extracts were distilled under reduced pressure to recover the solvent to obtain ethyl acetate and n-butanol extracts. Ethyl acetate and n-butanol extractions are brown viscous substances.

Embodiment 3

[0036] Carry out the silica gel (200-300 order) column chromatography of all ethyl acetate, sherwood oil: ethyl acetate (20:1-1:1), dot plate tracking, merge ratio shift value (R f value) the same flow segment, a total of 10 coarse segments (Fr.1-Fr.10) were obtained.

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Abstract

The invention discloses a cyrtomium fortunei extract and a preparation method and an application thereof and relates to a traditional Chinese medicine extract. The cyrtomium fortunei extract is prepared by the steps that tuber of cyrtomium fortunei which is a traditional Chinese medicine in Guizhou province is utilized as a raw material, the cyrtomium fortunei is subjected to extraction in ethanol to obtain an ethanol total extract, an ethanol total extract aqueous solution is sequentially subjected to extraction by petroleum ether, ethyl acetate and n-butyl alcohol, after reduced pressure distillation and solvent recovery, a petroleum ether extract, an ethyl acetate extract and an n-butyl alcohol extract are obtained, and the ethyl acetate and n-butyl alcohol extracts are respectively subjected to coarse segmentation by column chromatography to obtain coarse segmentation sections. The ethyl acetate and n-butyl alcohol extracts and the coarse segmentation sections have anti-cancer and oxidation resisting characteristics. The cyrtomium fortunei extract can be used for preparing anti-cancer and oxidation resisting medicines.

Description

technical field [0001] The invention relates to an extract of traditional Chinese medicine, in particular to an extract of Guizhou Chinese herbal medicine Guanzhong, and also relates to a preparation method and application of the extract of Guanzhong. Background technique [0002] Human aging and the occurrence of malignant tumors are both related to excessive free radicals in human cells, especially active oxygen free radicals. The DNA of every cell in the human body is damaged by 104 oxidative attacks every day. Free radicals destroy cell membranes, making cells unable to learn new things, and lose their ability to resist bacteria and viruses; free radicals attack genes that are being replicated, causing gene mutations and inducing cancer. The incidence of cancer is increasing at a rate of 3% to 5% every year, and the mortality rate caused by cancer has become the world's number one mortality rate. Therefore, finding effective anti-cancer and anti-oxidation drugs is stil...

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K36/11A61P35/00A61P39/06
Inventor 杨松杨胜杰薛伟胡德禹刘明川梁娜刘敏洁赵洪菊龚华玉
Owner GUIZHOU UNIV
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