Tebipenem pivoxil oral preparation and preparation method thereof
A tibipenem ester and oral preparation technology, which is applied in the field of carbapenem antibiotics, can solve the problems of children's poor taking compliance, and achieve the effects of improving drug taking compliance, improving taste, and simple process
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Embodiment 1
[0057] Example 1 Preparation of tibipenem-β-cyclodextrin inclusion compound
[0058] Weigh tibipenem 10g and β-cyclodextrin 30g, mix thoroughly, and then carry out DSC determination, the results are shown in image 3 .
[0059] The test results show that good Tibipenem-β-cyclodextrin inclusion compound can be obtained by physical mixing method.
Embodiment 2
[0060] Example 2 tibipenem granule 50mg / 0.5g
[0061] Prescription (1000 bags):
[0062]
[0063] Remarks: In the total amount of the preparation, based on tybipenem, 1g of tybipenem is equivalent to 1.3g of tybipenem. (The same below) Operation:
[0064] 1. Weigh the prescription amount of raw materials and mix them with β-cyclodextrin, and then fully mix them with other excipients;
[0065] 2. After the raw and auxiliary materials are fully mixed, add an appropriate amount of water-based soft materials containing pigments, granulate with a 16-mesh sieve and dry in a boiling dryer. The inlet air temperature is controlled at ≤60°C, and the material temperature is controlled at ≤40°C. The dry granules are granulated through a 14 mesh, and the essence is added and mixed to obtain tibipenem granules.
Embodiment 3
[0066] Example 3: tibipenem granule 50mg / 0.5g
[0067] Prescription (1000 bags):
[0068]
[0069] Operation is with embodiment 2.
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