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Anorectal administration drug

A medicament, anorectal technology, applied in the field of sustained-release medicaments, can solve the problems of prolonged wound healing time, no analgesic and anti-inflammatory effects, and difficulty in applying medicine to wounds, and achieve the effects of reducing wound bleeding, good hemostasis, and pain relief

Inactive Publication Date: 2012-12-12
凌峰 +2
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, since the human anus and the inner wall of the anorectum are very rich in blood vessels, and the external perception is also very sensitive, if gauze is used for packing, the pulling during dressing change will cause severe pain and bleeding of the patient, and at the same time, it is difficult to apply medicine to the wound surface and the wound healing time is prolonged.
After vaseline oil gauze, polymer materials and calcium alginate were used to treat wounds successively. Although there were improvements to varying degrees, there were still disadvantages such as slow hemostasis, inconvenient removal of plugs, and no analgesic and anti-inflammatory effects.

Method used

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Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0020] The anorectal plug filling agent of this embodiment is mixed by the following components:

[0021]

[0022] Among them, the main component of chitin as one of the active ingredients is chitosan, which is composed of 2-acetylamino-2-deoxy-D-glucopyranose and 2-amino-2-deoxy-D- Binary linear polymers of glucopyranose linked by β-(1→4) glycosidic bonds;

[0023] The main components of the Duanxueliu extract as the second active ingredient are: the whole plant contains Campanula saponin and Bogonginsa-9, 12, 17-triene 3β, 23-diol. Duanxueliu extract can be extracted from the roots, stems, leaves, flowers and other parts of Duanxueliu.

[0024] As the third active ingredient, the main components of Pollen extract are: flavonoids, naringenin, quercetin, rutinoside, isorhamnetin, isorhamnetin neohesperidoside, methyl palmitate, kaempferol Neohesperidoside and sitosterol. Cattail extract can be extracted from the pollen of cattails.

[0025] Azone is selected as the skin...

Embodiment 2

[0070] The anorectal plug filling agent of this embodiment is a change based on the first embodiment, except that it is the same as the first embodiment. The difference is: (1) the heating time of the anorectal plug filling agent during preparation is 12 minutes; (2) The mass percent of its component is as follows:

[0071]

[0072] (3) musk is selected as the skin penetration agent, and the consumption is 0.2% of the total mass of the anorectal plug filling agent; (4) the moisturizing agent is selected from propylene glycol, and the consumption is 2.797% of the total anorectal plug filling agent mass; (5) curing agent Active aluminum hydroxide is selected, and the dosage is 0.003% of the total mass of the anorectal plug filling agent.

[0073] The anorectal plug filling agent of this embodiment was subjected to hemostasis and antibacterial experiments respectively.

[0074] 1. Hemostasis experiment

[0075] 1. Using the normal saline solution of the anorectal plug fillin...

Embodiment 3

[0087] The anorectal plug filling agent of this embodiment is a change based on the first embodiment, except that it is the same as the first embodiment. The difference is: (1) the heating time of the anorectal plug filling agent during preparation is 25 minutes, (2) The mass percent of its component is as follows;

[0088]

[0089] (3) the skin penetration agent is selected from water, and the consumption is 0.8% of the total mass of the filling agent for the entire anorectal plug; (4) the moisturizing agent is selected from sorbitol, and the consumption is 2.198% of the total mass of the filling agent for the entire anorectal plug; (5) curing Active aluminum hydroxide is selected as the agent, and the dosage is 0.002% of the total mass of the anorectal plug filling agent.

[0090] The anorectal plug filling agent of this example was subjected to experiments on hemostasis and antibacterial in vivo.

[0091] 1. Hemostasis experiment

[0092] Get 8 rabbits, use the 20% aqu...

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Abstract

The invention relates to an anorectal administration drug which belongs to the technical field of medical preparation. The drug is prepared by mixing the following ingredients according to mass percent: 38-45% of chitin, 28-32% of Chinsee clinopodium herb extract, 22-28% of cattail pollen extract and the 1-5% of skin penetrant, wet storage agent and curing agent totally, wherein the chitin, the Chinsee clinopodium herb extract and the cattail pollen extract are active ingredients. After the drug of the invention is adopted, post-operation wound hemorrhage and pain can be quickly, effectively reduced, and the drug can exert the efficacy for 24 hours, prevents post-operation adhesion, diminishes swelling and inflammation, and accelerates healing; and moreover, and the drug can be used for avoiding pathogen damage and nerve fiber lesion.

Description

technical field [0001] The invention relates to a sustained-release medicament for hemostasis, pain relief, healing promotion and anti-inflammation for human surgical wounds, especially anorectal surgical wounds, and belongs to the technical field of medical preparations. Background technique [0002] The existing products for local hemostasis in the body mainly include fibrin glue, absorbable gelatin sponge, collagen sponge and oxidized cellulose, and these hemostatic materials have different hemostatic effects and functions. However, the hemostatic function is mainly achieved by long-term compression, and the effect of rapid hemostasis is not ideal. Among them, fibrin glue, which is widely used in clinical practice, is a protein biological product extracted from animal plasma. It has good hemostatic effect, but it has certain antigenicity and the risk of spreading blood viral diseases. [0003] At present, the wound treatment method after the anorectal disease operations ...

Claims

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Application Information

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IPC IPC(8): A61K36/88A61P7/04A61P29/00A61P41/00A61P31/04A61P31/10A61K31/722
Inventor 凌峰凌云凌晨
Owner 凌峰
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