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Application of slender dioscin and pharmaceutical composition containing the same

A technology of diosgenin slender and composition is applied in the field of pharmaceutical compositions containing diosgenin slender, which can solve problems such as inconclusive active ingredients, achieve good application prospects, and reduce the effects of adhesion and lumps.

Inactive Publication Date: 2012-11-21
NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the exact effective part or active ingredient of Smilax has not yet been determined.

Method used

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  • Application of slender dioscin and pharmaceutical composition containing the same
  • Application of slender dioscin and pharmaceutical composition containing the same
  • Application of slender dioscin and pharmaceutical composition containing the same

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] The preparation of embodiment 1 fine diosgenin, diosgenin and protodioscin

[0028] Smilax crude drug 1kg was refluxed in 75% ethanol water bath for 2h, and the ethanol extract was collected. After 3 alcohol extractions, the alcohol extracts were combined. After recovering ethanol, put it on a polyamide column (30-60 mesh) at a flow rate of about 5BV (volume of polyamide) h. The column was washed with distilled water, and the water washings were collected. Then with 95% ethanol, the flow rate is about 2.5BVh. Rinse the polyamide column and collect the eluate. Use NaHCO3 to adjust the pH value of the above-mentioned washing solution to 4-5, add sodium chloride to 1.5 mol / L, put it on a macroporous resin column (D101, resin branch of Tianjin Pesticide Co., Ltd., batch number: 20020407), and wash it with water until Eluate to neutral. With 75% ethanol, the flow rate is about 2.5BVh. Rinse, collect the eluate, and recover ethanol through a rotary evaporator to obtain ...

Embodiment 2

[0029] Example 2 Preparation of preparation containing fine diosgenin (1)

[0030] Take 80 g of fine diosgenin prepared according to the method of Example 1, add 5 g of poloxamer, 2.5 g of povidone, 2.5 g of lecithin, and 5 g of microcrystalline cellulose. The above ingredients are fully mixed, and 5 g of 10% starch slurry is added as a binder, then granulated, dried, and sized to prepare 200 tablets in total and coated.

Embodiment 3

[0031] Example 3 Preparation of slimy diosgenin preparation (2)

[0032] Take 60 g of fine diosgenin prepared according to the method of Example 1, add 10 g of poloxamer, 5 g of povidone, 5 g of lecithin, and 10 g of microcrystalline cellulose. The above ingredients are fully mixed, and 10 g of 10% starch slurry is added as a binder, then granulated, dried, sized, pressed into 200 tablets, and coated.

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Abstract

The present invention relates to application of slender dioscin and a pharmaceutical composition containing the slender dioscin. The invention provides application of the slender dioscin to prevention and / or treatment of acute or chronic inflammation, such as the treatment of gynecological inflammation. The invention also relates to application of the slender dioscin as a chinaroot greenbrier effective active component. The invention also relates to a preparation method of the slender dioscin.

Description

technical field [0001] The invention relates to the use of diosgenin, an active ingredient of sarsaparilla, and a pharmaceutical composition containing diosgenin. Background technique [0002] Smilax is the rhizome of Liliaceae Smilax Smilax chinaL. It is mainly distributed in the south of the Yangtze River in my country and is rich in resources. It is recorded in Part I of the 2005 edition of "Chinese Pharmacopoeia". It is a commonly used Chinese medicinal material. It has the effects of dispelling wind and dampness, detoxifying and dispelling blood stasis. It is mainly used for various gynecological inflammations, and the curative effect is remarkable. The traditional Chinese medicine preparation "Jingangteng Capsule" is clinically used to treat gynecological inflammatory diseases with remarkable curative effect. However, the traditional Chinese medicine preparation is prepared by a traditional production process, and its anti-inflammatory material basis is still unclear....

Claims

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Application Information

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Patent Type & Authority Applications(China)
IPC IPC(8): A61K31/7048A61P29/00A61P15/00
Inventor 侯连兵黄嗣航马云杨西晓王春霞李晓
Owner NANFANG HOSPITAL OF SOUTHERN MEDICAL UNIV
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