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Hydrogel dressing and preparation process thereof

A preparation process and hydrogel technology, which is applied in medical science, bandages, absorbent pads, etc., can solve the problems of single function and less hydrogel, and achieve the effects of good degradability, increased viscosity, and strong antibacterial properties

Active Publication Date: 2012-11-07
WUHAN HUMANWELL MEDICAL SUPPLIES
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, the hydrogels prepared by this method are still very few, and the functions are relatively simple.

Method used

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  • Hydrogel dressing and preparation process thereof
  • Hydrogel dressing and preparation process thereof
  • Hydrogel dressing and preparation process thereof

Examples

Experimental program
Comparison scheme
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Embodiment 1

[0027] The hydrogel dressing provided in the present embodiment is made up of 3% carboxymethyl chitosan CMCS, 1.5% hydroxyethyl cellulose HEC, 15% propylene glycol, 0.01% benzalkonium bromide and water. The preparation process is as follows:

[0028] First, weigh each component according to the above ratio, wherein the carboxymethyl chitosan CMCS used is carboxymethyl chitosan CMCS with a 2% aqueous solution viscosity of 160-1000Cp at 20°C, and the hydroxyethyl cellulose used HEC is hydroxyethyl cellulose HEC with a viscosity of 10,000 to 50,000 Cp in a 2% aqueous solution at 20°C. Dissolve carboxymethyl chitosan CMCS in water, and heat the solution to 60°C, then add hydroxyethyl cellulose HEC into the solution and stir well. Propylene glycol and benzalkonium bromide are sequentially added to the above solution and fully stirred to obtain a final solution, and the hydrogel dressing can be prepared after the final solution is allowed to stand at room temperature for defoaming....

Embodiment 2

[0031] The hydrogel dressing provided in the present embodiment is made up of 2.7% carboxymethyl chitosan CMCS, 1.5% hydroxyethyl cellulose HEC, 16% propylene glycol, 0.011% benzalkonium bromide and water. The preparation process is as follows:

[0032] First, weigh each component according to the above ratio, wherein the carboxymethyl chitosan CMCS used is carboxymethyl chitosan CMCS with a 2% aqueous solution viscosity of 160-1000Cp at 20°C, and the hydroxyethyl cellulose used HEC is hydroxyethyl cellulose HEC with a viscosity of 10,000 to 50,000 Cp in a 2% aqueous solution at 20°C. Dissolve carboxymethyl chitosan CMCS in water, and heat the solution to 62°C, then add hydroxyethyl cellulose HEC into the solution and stir well. Propylene glycol and benzalkonium bromide are sequentially added to the above solution and fully stirred to obtain a final solution, and the hydrogel dressing can be prepared after the final solution is allowed to stand at room temperature for defoami...

Embodiment 3

[0035] The hydrogel dressing provided in the present embodiment is made up of 3.1% chitosan quaternary ammonium salt, 1.7% hydroxyethyl cellulose HEC, 15.8% propylene glycol and water, and its preparation process is as follows:

[0036] First weigh each component according to the above ratio, wherein the chitosan quaternary ammonium salt used is the chitosan quaternary ammonium salt under the condition of molecular weight 500~500000, quaternary ammonium group substitution degree 0.1~1.0, the chitosan quaternary ammonium salt is 20 At 20°C, the viscosity of 2% aqueous solution is 1-1000 Cp, and the hydroxyethyl cellulose HEC used is hydroxyethyl cellulose HEC at 20°C, the viscosity of 2% aqueous solution is 10000-50000 Cp. Dissolve chitosan quaternary ammonium salt in water, and heat the solution to 58.5°C, then add hydroxyethyl cellulose HEC into the solution and stir well. Propylene glycol is added into the above solution and fully stirred to obtain a final solution, and the ...

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Abstract

The invention provides a hydrogel dressing which comprises HEC (hydroxyethyl cellulose), propylene glycol, water and one of CMCS (carboxymethyl chitosan) and chitosan hyamine. A preparation process of the hydrogel dressing includes the steps: taking components for standby application according to the ratio of the components as demanded; dissolving the CMCS or the chitosan hyamine in water and heating the CMCS or the chitosan hyamine; adding the HEC into solution and sufficiently stirring the solution; adding the propylene glycol into the solution and sufficiently stirring the solution to obtain final solution; and standing and defoaming the final solution to obtain the hydrogel dressing. The hydrogel dressing has fine biocompatibility and degradability, and has a sterilizing function, so that high antibacterial activity can be achieved when a wound is treated, and high toxicity is avoided.

Description

technical field [0001] The invention relates to a biodegradable hydrogel dressing and a preparation process thereof, in particular to a dressing containing carboxymethyl chitosan (CMCS) or chitosan quaternary ammonium salt, and hydroxyethyl cellulose (HEC) Hydrogel dressings of macromolecular substances. Background technique [0002] Hydrogels are gels in which water is the dispersion medium. By introducing a part of hydrophobic groups and hydrophilic residues into the water-soluble polymer with a network crosslinked structure, the hydrophilic residues combine with water molecules to connect the water molecules inside the network, while the hydrophobic residues meet with water swell. Hydrogel is a polymer network system, which is soft in nature, can maintain a certain shape, and can absorb a large amount of water. All water-soluble or hydrophilic polymers can form hydrogels through certain chemical cross-linking or physical cross-linking. [0003] According to different ...

Claims

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Application Information

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IPC IPC(8): A61L15/28A61L15/42
Inventor 尹乃达周应山贾云昆
Owner WUHAN HUMANWELL MEDICAL SUPPLIES
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