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Botanical drug compound recipe for preventing and treating microwave radiation injury

A technology of microwave radiation and medicine, which is applied in the direction of medical formula, plant raw materials, plant/algae/fungus/moss components, etc., can solve the problems of large dosage, inconvenience, high price, etc., and achieve the effect of excellent effect and enhanced immune function

Active Publication Date: 2012-10-17
INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA +1
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004]Although Andolin Capsules has obvious therapeutic effects on microwave radiation damage, the dosage of the drug is relatively large, which brings some inconvenience to the users and is relatively expensive

Method used

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  • Botanical drug compound recipe for preventing and treating microwave radiation injury
  • Botanical drug compound recipe for preventing and treating microwave radiation injury
  • Botanical drug compound recipe for preventing and treating microwave radiation injury

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0065] Example 1 Preparation of compound medicine for preventing and treating microwave radiation damage (1)

[0066] formula:

[0067] Red peony 700g, Astragalus 1500g, Green pineapple 1200g, Salvia 830g, Chinese wolfberry 580g, Chuanxiong 420g

[0068] Preparation method:

[0069] 1) Add the ingredients in the above formula (except for the green pineapple) to decoction twice for 1.5 hours each, filter and collect the filtrate;

[0070] 2) Heat the chlorella and ethanol to reflux for 1.5 hours, and filter; after the ethanol is filtered out, the ethanol is recovered. Decoction the medicine residue in water for 1.5 hours, filter, and collect the filtrate;

[0071] 3) Combine the filtrate in steps 1) and 2) above, and concentrate it to an extract with a relative density of 1.4 to 1.5;

[0072] 4) The obtained extract is dried, crushed, and divided into 1000 capsules.

[0073] Finished product: This product is a hard capsule, the content is brown-yellow powder with slightly fishy smell and s...

Embodiment 2

[0075] Example 2 Preparation of compound medicine for preventing and treating microwave radiation damage (2)

[0076] formula:

[0077] Red peony 700g, Astragalus 1500g, Lvyan 1200g, Salvia 830g, Wolfberry 580g

[0078] Chuanxiong 420g Ligustrum 440g Ginseng 44g Green Tea 330g

[0079] The preparation method, finished product and use method are the same as in Example 1.

[0080] The following are the formulations of 8 different medicines of the present invention, and the preparation methods are the same as in Example 1.

[0081]

[0082] Note: The data in the table are parts by weight.

[0083] Pharmacodynamic experiment description of the drug of the present invention

[0084] In the following experiments, the "Kangfuling" is the drug formulated in Example 1 of the present invention.

[0085] In the pharmacodynamic experiments of the following examples, unless otherwise specified, proceed as follows:

[0086] 1. Laboratory animals and groups

[0087] 120 secondary Wistar male rats (Academy o...

Embodiment 4

[0197] Example 4 Pharmacodynamic experiment of formula

[0198] Formula: Red peony 8, Astragalus 18, Lupin 14, Salvia 10, Chinese wolfberry 7, Chuanxiong 5, Ligustrum lucidum 5.

[0199] Experiment on changes of rat sperm motility parameters

[0200] 6h after the drug was stopped, that is, 14 days after the radiation, the radiation control group was compared with the normal control group, the activity rate (A+B) sperm ratio of the radiation control group was significantly reduced (p<0.05), while the C-level sperm ratio was significantly increased (p<0.01 ), the proportion of class D sperm has an increasing trend; the motility parameter curve velocity (VCL), linear velocity (VSL), and average velocity (VAP) have a significant downward trend as the sperm motility rate decreases. Compared with the normal control group, the proportion of A+B sperm and AR sperm in each dose of the drug group decreased, and the proportion of D sperm increased, but there was no statistical difference; each...

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Abstract

The invention relates to a botanical drug compound recipe for preventing and treating microwave radiation injury. According to the invention, it is found that botanical drugs mainly consisting of peony root, milkvetch root, duckweed and red sage root can be used for preparing a medicine used for preventing and treating microwave radiation injury. According to results of abundant experiments of detection of learning and memory capacity of rats, hippocampal amino acid neurotransmitters, sperm motility, the rate of teratosperm, myocardial metabolic enzyme (CK-MB, LDH and AST activity) and the content of Ca<2+> in serum of rats, the number of peripheral blood lymphocytes and the like, the medicine provided in the invention has an obvious treatment effect on injury to the brain, reproduction, the heart and immunity of rats caused by microwave radiation, and the effect is superior to that of medicines on the market.

Description

Technical field: [0001] The invention relates to a compound medicine for preventing and treating microwave radiation damage, in particular to a plant medicine compound. Background technique: [0002] Studies have confirmed that microwave radiation has obvious damage to humans and animals, and can cause changes in multiple systems. Such as 30mW / cm 2 Microwave radiation has a detrimental effect on the spatial learning and memory ability of rats; it can cause the metabolic disorder of amino acid neurotransmitters in the hippocampus, which is manifested by the decrease of glycine and γ-aminobutyric acid content; it causes the decrease of lymphocytes in the peripheral blood of rats, CK-MB, LDH and AST activity and Ca 2+ The content increases; it causes a decrease in the sperm motility rate of the rat epididymis, and an increase in sperm mortality and deformity rate. [0003] In the prior art, there are few medicines for preventing and treating microwave radiation damage. The anti-micr...

Claims

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Application Information

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IPC IPC(8): A61K36/71A61P17/16
Inventor 彭瑞云刘韧董霁姚斌伟胡韶华张雪岩高亚兵王水明徐新萍左红艳王丽峰赵黎刘曙晨刘润东刘中柱
Owner INST OF RADIATION MEDICINE ACAD OF MILITARY MEDICAL SCI OF THE PLA
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