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Method for detecting residual quantity of perfluoroalkylation compounds in cosmetics

A perfluoroalkyl and detection method technology, applied in measuring devices, instruments, scientific instruments, etc., can solve problems such as no perfluoroalkyl compound method, and achieve advanced detection methods, good precision and reproducibility Effect

Inactive Publication Date: 2012-10-10
吉林出入境检验检疫局检验检疫技术中心
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0004] At present, there is no report on the method for detecting perfluoroalkyl compounds

Method used

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  • Method for detecting residual quantity of perfluoroalkylation compounds in cosmetics
  • Method for detecting residual quantity of perfluoroalkylation compounds in cosmetics
  • Method for detecting residual quantity of perfluoroalkylation compounds in cosmetics

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0051] liquid sample

[0052] 1. Weigh 1g sample (Lotion No. 1 provided by Liaoning Entry-Exit Inspection and Quarantine Bureau) into a 50 mL centrifuge tube, add 20 mL methanol, shake and extract with an oscillator for 30 min, then ultrasonically extract for 20 min; place in a centrifuge Centrifuge at 10000 r / min for 10 min. Pipette the supernatant into a 250 mL concentrator bottle and repeat the above extraction steps, combine the extracts, and concentrate by rotary evaporation in a water bath at 40 °C. Dilute to 10 mL with methanol, take 1 mL of the solution in a polypropylene centrifuge tube, dilute to 20 mL with water, adjust the pH to 4-5 with 2% formic acid, and wait for purification.

[0053] 2. After the extraction is complete, transfer the extract to a 250 mL concentrator bottle, and concentrate by rotary evaporation in a water bath at 40 °C. Dilute to 10 mL with methanol, take 1 mL of the solution in a polypropylene centrifuge tube, dilute to 20 mL with water, a...

Embodiment 2

[0055] powdery, milky samples

[0056] Weigh 1 g of sample (Lipstick No. 2 provided by Liaoning Entry-Exit Inspection and Quarantine Bureau), add about 5 g of diatomaceous earth, and mix well; put it into the extraction pool for extraction, and the extraction conditions of the fast solvent extraction instrument: Sample pool temperature: 80 ℃ ; Pressure: 1500 psi; Heating time: 5 min; Static extraction time: 5 min; Solvent: methanol; Flushing volume: methanol (60% of the sample cell volume); Nitrogen purge: 60 s; After completion, the extract was transferred to a 250 mL concentrator bottle, and concentrated by rotary evaporation in a water bath at 40 °C. Dilute to 10 mL with methanol, take 1 mL of the solution in a polypropylene centrifuge tube, dilute to 20 mL with water, adjust the pH value to 4-5 with 2% formic acid, and wait for purification;

Embodiment 3

[0058] powdery, milky samples

[0059] Weigh 1 g of sample (emulsion No. 3 provided by Liaoning Entry-Exit Inspection and Quarantine Bureau), add about 5 g of diatomaceous earth, mix well; put it into the extraction pool for extraction, extraction conditions of fast solvent extraction instrument: sample pool temperature: 80 ℃ ; Pressure: 1500 psi; Heating time: 5 min; Static extraction time: 5 min; Solvent: methanol; Flushing volume: methanol (60% of the sample cell volume); Nitrogen purge: 60 s; After completion, the extract was transferred to a 250 mL concentrator bottle, and concentrated by rotary evaporation in a water bath at 40 °C. Dilute to 10 mL with methanol, take 1 mL of the solution in a polypropylene centrifuge tube, dilute to 20 mL with water, adjust the pH value to 4-5 with 2% formic acid, and wait for purification;

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Abstract

The invention discloses a method for detecting the residual quantity of perfluoroalkylation compounds in cosmetics. The method is characterized in that compositions to be detected are separated from large quantities of base materials in a cosmetic sample by extracting and purifying steps, and the compositions to be detected are further separated from other compositions which interfere with measurement, and are purified by means of purification, so that the problem that detection cannot be carried out due to excessive interferences is solved. The method is advanced, is good in precision and repeatability, and can be used for comprehensively detecting the perfluoroalkylation compounds in the cosmetics.

Description

technical field [0001] The invention discloses a method for detecting the residual amount of perfluoroalkyl compounds in cosmetics, and belongs to the technical field of chemical substance detection methods. Background technique [0002] The types of perfluoroalkyl compounds in cosmetics involved in the present invention include perfluorocaproic acid, perfluorooctanoic acid, perfluorononanoic acid, perfluorodecanoic acid, perfluoroundecanoic acid, perfluorododecanoic acid, perfluorobutanesulfonic acid, Perfluorohexane sulfonic acid, perfluorooctane sulfonic acid, and perfluorodecane sulfonic acid, the above-mentioned substances are harmful to the human body in use. The current toxicological tests have proved that the toxicity of perfluoroalkyl compounds is still unacceptable. Neglected, if humans are exposed to fluorocarbon surfactants for a long time, there may be acute or chronic toxicity. Systemic effects can be caused by oral administration, inhalation or skin penetratio...

Claims

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Application Information

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IPC IPC(8): G01N30/02G01N30/08G01N30/14
Inventor 周晓卢利军刘晶张代辉胡婷婷吴连鹏
Owner 吉林出入境检验检疫局检验检疫技术中心
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