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Chinese wolfberry formula granule and its preparation method and detection method

A technology of formula granules and wolfberry leaves, which is used in pharmaceutical formulas, medical preparations containing active ingredients, measuring devices, etc.

Active Publication Date: 2016-08-17
广东省中医药工程技术研究院
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

[0007] At present, there is no report on the quality control of wolfberry leaf formula granules using infrared spectroscopy

Method used

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  • Chinese wolfberry formula granule and its preparation method and detection method
  • Chinese wolfberry formula granule and its preparation method and detection method
  • Chinese wolfberry formula granule and its preparation method and detection method

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0052] The preparation method of wolfberry leaf formula granules of the present embodiment is as follows:

[0053] (1) Take the raw wolfberry leaf, add 12 times the weight of water of the raw wolfberry leaf, soak for 1.5 hours, extract for 3 hours, heat and boil, keep it slightly boiled, heat and cook for 2 hours, and filter the extract; the second time Add 10 times the amount of water, heat and cook for 1.5h, filter, and combine the extracts.

[0054] (2) Pump it into the concentrator, control the concentration temperature between 50 and 80 °C, and concentrate it to a relative density of 1.12 to obtain "Legacy Leaf Clearing Paste". Heating to not less than 40℃, spray drying, controlling the inlet air temperature to 185℃, the outlet air temperature to 95℃, the negative pressure in the tower -0.03~-0.06Mpa, and the received spray dry powder is 8.9kg;

[0055] (3) Add 1.1kg of maltodextrin, mix well, dry granulation (the hole diameter of the punching plate is between 1.30 and 1...

Embodiment 2

[0061] The preparation method of wolfberry leaf formula granules of the present embodiment is as follows:

[0062] (1) Take 90kg of the raw medlar leaves, add 10 times the weight of water of the raw medlar leaves, heat and boil, keep slightly boiling, heat and cook for 3 hours, and filter the extract; add 8 times the amount of the feed for the second time. water, heated and boiled for 1 h, filtered, and the extracts were combined;

[0063] (2) Pump it into the concentrator, control the concentration temperature between 50 and 80°C, and concentrate it to a relative density of 1.24 to obtain "Legacy Leaf Clearing Paste". , control temperature 60~75 ℃ (slowly heating up), vacuum degree -0.07~-0.085Mpa, and receive 9.2kg of dried extract of wolfberry leaves;

[0064] (3) Pulverize, add 0.8kg of maltodextrin, mix well, and dry granulation (the hole diameter of the punching plate is between 1.30 and 1.70mm, the pressure of the oil cylinder is 20±7bar, the speed of the feeding screw...

Embodiment 3

[0073] The preparation method of wolfberry leaf formula granules of the present embodiment is as follows:

[0074] (1) Take 90kg of raw medlar leaves, add 8 times the weight of water of raw medlar leaves, heat and boil, keep slightly boiling, heat and decoct for 2 hours, and filter the extract; add 6 times the amount of feed for the second time. water, heated and boiled for 1.5h, filtered, and the extracts were combined;

[0075] (2) Pump it into the concentrator, control the concentration temperature between 50 and 80°C, and concentrate it to a relative density of 1.13 to obtain the "Legacy of Gouguye Qinggao". Heating to not less than 40℃, spray drying, controlling the inlet air temperature to 175℃, the outlet air temperature to 85℃, the negative pressure in the tower -0.03~-0.06Mpa, and the sprayed dry powder is 8.3kg;

[0076] (3) Add 1.7kg of maltodextrin, mix well, dry granulation (the hole diameter of the punching plate is between 1.30 and 1.70mm, the pressure of the o...

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Abstract

The invention discloses an ilicis cornutae folium formula granule, a preparation method and a detection method thereof. The formula granule is prepared in the following steps: preparing an ilicis cornutae folium dried powder by using ilicis cornutae folium as a raw material through water extraction, compression in reduced pressure, drying and other process flows, and performing dry-method granulation directly by ilicis cornutae folium dried powder or mixing with a proper amount of auxiliaries. A gram of ilicis cornutae folium formula granule is equivalent to 9g of a raw drug, and ilicis cornutae folium decoction pieces and ilicis cornutae folium formula granule are subjected to quality detection by adopting infrared fingerprint spectrum. The ilicis cornutae folium has a complete and advanced production process and a controllable detection standard with strong specific, the advanced process can be realized, and the quality standard relates to a scientific, advanced and quick detection method which is strong in operability.

Description

technical field [0001] The invention relates to a traditional Chinese medicine formula granule and a preparation method and a detection method thereof, in particular to a wolfberry leaf formula granule and a preparation method and a detection method thereof. Background technique [0002] Chinese herbal formula granules are granules made from Chinese herbal decoction pieces through various processes under the guidance of TCM theory, and are used for the preparation of clinical TCM prescriptions. The traditional Chinese medicine formula granules have the advantages of small size, easy to carry and store, stable and controllable quality, etc. As a new type of decoction to replace traditional Chinese medicine pieces, it is convenient, fast, safe, hygienic and scientific. [0003] The leaves are the dried leaves of Ilex cornuta Lindl.ex Paxt. of the Ilex cornuta plant. It has the functions of clearing heat and nourishing yin, invigorating the kidney and calming the liver. It is...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): A61K36/185A61K9/16A61P9/12G01N21/3563G01N30/02
Inventor 孙冬梅王洛临施之琪李智勇徐文杰
Owner 广东省中医药工程技术研究院
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