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Application of oleanolic acid to medicine for treating obesity

A technology of oleanolic acid, obesity, applied in the application field of medicine, to achieve the effect of preventing the rise and ensuring the effectiveness

Inactive Publication Date: 2012-10-10
FOURTH MILITARY MEDICAL UNIVERSITY
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

Therefore, simply releasing triglycerides from fat cells cannot fundamentally solve the obesity problem, and promoting the decomposition of triglycerides is a direct and effective way to treat obesity

Method used

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  • Application of oleanolic acid to medicine for treating obesity
  • Application of oleanolic acid to medicine for treating obesity
  • Application of oleanolic acid to medicine for treating obesity

Examples

Experimental program
Comparison scheme
Effect test

Embodiment

[0015] 1. Experimental equipment

[0016] Electronic scales for animals, blood glucose monitors (Johnson & Johnson), precision electronic balances, cameras, 1ml syringes, etc.

[0017] 2. Experimental animals and materials

[0018] 2.1 Experimental animals

[0019] SD rats, clean grade, male, weighing 180±220 g, were provided by the Experimental Animal Center of Fourth Military Medical University.

[0020] 2.2 Experimental materials

[0021] Physiological saline, picric acid, blood glucose test strips, insulin, glycerin determination kits.

[0022] 3. Experimental method

[0023] 24 db / db mice (6-8 weeks old) were randomly divided into 3 groups: positive group: db / db mice; OA low-dose treatment group: 10mg / kg OA; OA high-dose treatment group: 20mg / kg OA . Wild type (WT) db / m mice were set as normal controls (8). In the OA treatment group, 10 mg / kg or 20 mg / kg OA was injected intraperitoneally (the administration solvent was 2% Tween 80 normal saline). The positive grou...

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PUM

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Abstract

The invention discloses a purpose of oleanolic acid and belongs to an application of oleanolic acid to medicine for treating obesity. The oleanolic acid is injected into the abdominal cavities of db / db mice with obesity and diabetes, the blood sugar level can be obviously reduced, the body weight increase is obviously decelerated, and the internal organ fat content is obviously reduced. The oleanolic acid is added in the primary adipocyte culture liquid, and the decomposition of triglyceride can be obviously promoted. Therefore, the oleanolic acid can be used in medicine for treating the obesity and relevant diseases caused by the obesity, and in addition, side effects of possibly existing blood circulation free fatty acid increase during the body weight reduction, or even the insulin resistance and the like of the traditional weight reducing medicine can be overcome.

Description

technical field [0001] The invention relates to the use of oleanolic acid, in particular to the application of oleanolic acid in medicines for treating obesity and related diseases caused by obesity. Background technique [0002] Currently, obesity has become a global health problem. If it continues to become serious, obesity will soon overtake smoking as the largest single risk factor for premature death in the United States, reducing the quality of life and increasing social costs. According to the US CDC statistics, 1 / 3 of American adults are already obese, and 1 / 3 of them are overweight, and the degree of obesity is increasing year by year. According to a study in the Journal of the American Medical Association, more than 160,000 people in the United States die "accidentally" each year from obesity. According to scientists, the average obese person costs society more than $7,000 a year due to increased productivity and medical costs. In recent years, due to the rapid ...

Claims

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Application Information

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IPC IPC(8): A61K31/56A61P3/04
Inventor 王欣海春旭
Owner FOURTH MILITARY MEDICAL UNIVERSITY
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