Therapeutic or prophylactic agent for biliary diseases

A technology for preventing medicines and diseases, which is applied in the directions of drug combinations, pharmaceutical formulations, and medical preparations containing active ingredients to achieve significant therapeutic or preventive effects.

Active Publication Date: 2012-10-03
TORAY IND INC
View PDF20 Cites 3 Cited by
  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

It is also documented that although Eptazocine, which does not have a morphinane skeleton, but is known to exert a κ agonist action on opioid receptors, contraction of the sphincter

Method used

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
View more

Image

Smart Image Click on the blue labels to locate them in the text.
Viewing Examples
Smart Image
  • Therapeutic or prophylactic agent for biliary diseases
  • Therapeutic or prophylactic agent for biliary diseases
  • Therapeutic or prophylactic agent for biliary diseases

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0108] Example 1 (-)-17-(cyclopropylmethyl)-3,14β-dihydroxy-4,5α-epoxy-6β-[N-methyl-trans-3-(3-furyl)acrylamide ]Effect of morphinane hydrochloride (compound 1) on contraction of rabbit sphincter of Oddi

[0109] The method described in Wei JG et al., World J. Gastroenterol., 6, 102 (2000) was partially modified to measure changes in the perfusion resistance pressure of the sphincter of Oddi. It should be noted that the changes in the perfusion resistance pressure of the sphincter of Oddi reflect the contraction of the sphincter of Oddi.

[0110] NZW male rabbits (Japan SLC) with a body weight of 2.0 to 2.5 kg upon arrival were used, and fasting was started from the evening of the day before the experiment. The experiment was carried out under pentobarbital anesthesia and artificial ventilation. The rabbit was fixed in the dorsal position, after which the abdomen was incised to expose the periduodenum and common bile duct. The common bile duct was cut slightly, and the ca...

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

PUM

No PUM Login to view more

Abstract

Disclosed is a novel medicinal agent which has an excellent therapeutic effect on biliary diseases and is therefore is useful for the treatment or prevention of biliary diseases. Specifically disclosed is a therapeutic or prophylactic agent for biliary diseases, which comprises a compound having a specific morphinan backbone typified by compound 1 or a pharmacologically acceptable acid addition salt thereof as an active ingredient.

Description

technical field [0001] The present invention relates to a medicine for treating or preventing biliary tract disease which contains Morphinan derivative or its pharmacologically acceptable acid addition salt as an active ingredient. Background technique [0002] Biliary tract disease refers to the general term for digestive system diseases that occur in the gallbladder or bile duct or pancreas or pancreatic duct. As one of the causes of biliary tract diseases, it is known that the biliary resistive pressure increases due to the contraction of Oddi's sphincter muscle at the duodenal papilla, which is the terminal part of the bile duct after the common bile duct, which is the most downstream of the biliary duct, joins the pancreatic duct. Examples of biliary diseases caused by contraction of the sphincter of Oddi include biliary occlusion, gallbladder disorder, gallstone, pancreatitis, biliary dyskinesia, cholangitis, and cholecystitis. Therefore, it is known that a drug that ...

Claims

the structure of the environmentally friendly knitted fabric provided by the present invention; figure 2 Flow chart of the yarn wrapping machine for environmentally friendly knitted fabrics and storage devices; image 3 Is the parameter map of the yarn covering machine
Login to view more

Application Information

Patent Timeline
no application Login to view more
IPC IPC(8): A61K31/485A61P1/16A61P1/18C07D489/02
CPCA61K31/485C07D489/08C07D489/00C07D489/02A61P1/16A61P1/18
Inventor 小林良辅中尾薰
Owner TORAY IND INC
Who we serve
  • R&D Engineer
  • R&D Manager
  • IP Professional
Why Eureka
  • Industry Leading Data Capabilities
  • Powerful AI technology
  • Patent DNA Extraction
Social media
Try Eureka
PatSnap group products

Browse by: Latest US Patents, China's latest patents, Technical Efficacy Thesaurus, Application Domain, Technology Topic.

© 2024 PatSnap. All rights reserved.Legal|Privacy policy|Modern Slavery Act Transparency Statement|Sitemap