Method for producing glucose bulk drug for injection by using rice

Abstract

The invention provides a method for producing a glucose bulk drug for injection by using rice. The method comprises the following steps of: soaking and defibrination, size mixing, liquefaction and slag removal, saccharification, primary decoloration and filtration, secondary decoloration and filtration, ion exchange, concentration and refining, primary crystallization, primary centrifugation, sugar solution, sugar concentration and decoloration, secondary sugar boiling and crystallization, secondary centrifugation, drying, packaging and the like. The method has the following advantages: (1), a two-time crystallization process is adopted, the quality is high, and a filtration speed is quick; (2), the problem that a raw material for producing an injection glucose in the south does not existis solved by using the rice as the raw material, and the blank of the production of a crystalline glucose in the south is filled; (3), the crystalline glucose produced by using the rice as the raw material has low-irritability in absorption property and is high in biological value; and (4), a breeding fermentation problem in a production procedure is solved successfully, the sugar concentration and the filtration are added, the quality of a finished product is greatly improved, and the clarity and the filtration speed of the product are guaranteed. The continuous feed and the continuous discharge can be carried out; the crystallization and fermentation contamination is stopped; the quality can be guaranteed; and the continuous production is guaranteed.

Description

technical field [0001] The invention belongs to the technical field of medical drug production, and in particular relates to a method for producing glucose bulk drug for injection by using rice. Background technique [0002] Currently used glucose for injection is prepared from cornstarch, and Japan uses cassava to prepare glucose for injection. Rice starch has only been made into edible glucose, and there is no report of making glucose for injection. Corn starch slurry contains less protein and larger starch particle size. The protein content of rice is 7.0-10.0%, the starch particle size is small, and the starch and protein are combined into a tight network structure. The size of starch granules determines the gelatinization temperature of starch and affects the liquefaction of starch. Corn starch has a low gelatinization temperature and is easy to liquefy, while rice starch has a small particle size and a high gelatinization temperature of 85°C, and is tightly combined...

AI Technical Summary

Problems solved by technology

The DE of corn starch after liquefaction and saccharification is more than 98%, while rice starch is difficult to complete after liquefaction and saccharification, and there are many impurities, so it is very difficult to make glucose for injection