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Spinning dope and method for producing biomedical fiber

A kind of spinning stock solution and biological technology, applied in spinning solution preparation, wet spinning method, medical science, etc., can solve problems such as complex manufacturing procedures and difficult control of HA content of chitosan fibers

Active Publication Date: 2015-08-26
TAIWAN TEXTILE RESEARCH INSTITUTE
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  • Summary
  • Abstract
  • Description
  • Claims
  • Application Information

AI Technical Summary

Problems solved by technology

However, in this technique, HA only diffuses into the vicinity of the surface of chitosan fibers, and it is not easy to control the content of HA in chitosan fibers. Furthermore, this requires more complicated manufacturing procedures

Method used

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  • Spinning dope and method for producing biomedical fiber
  • Spinning dope and method for producing biomedical fiber

Examples

Experimental program
Comparison scheme
Effect test

Embodiment 1

[0027] 1.1 Preparation of biomedical fibers containing HA and chitosan

[0028] 50g of chitosan, 25g of acetic acid (CH 3 COOH) was mixed with 950 g of water and stirred at room temperature for 3 hours to completely dissolve the chitosan. Then, 25 g of HA was added to form a spinning dope. In addition, 50 g of sodium hydroxide, 475 g of methanol, and 475 g of water were mixed to prepare a molding liquid.

[0029] In the process of wet spinning, the pump flow rate of the wet spinning machine is set to 1.5ml / min, and the spinning dope is squeezed into the forming liquid through a spinning nozzle (with 500 holes, each hole has a diameter of 10 μm) Form biomedical fibers. The biomedical fibers were then placed in a vacuum dryer to remove residual solvents (water and methanol).

[0030] 1.2 Preparation of biomedical fibers containing gelatin and chitosan

[0031] In this example, biomedical fibers were prepared using the same method as in Example 1.1, except that gelatin was u...

Embodiment 2

[0035] Embodiment 2: Characteristic analysis of the biomedical fiber of embodiment 1

[0036] The blood-clotting effects of the biomedical fibers prepared in Example 1 were quantified by the following test methods. Briefly, 100 μL of blood was dropped on 0.1 g of biomedical fabric samples (nonwoven fabrics made of the biomedical fibers of Examples 1.1, 1.2 and 1.3). After standing for a period of time (for example, 15, 30, 60 and 120 seconds), the biomedical material fabric sample with blood was soaked in a container containing 10 ml of physiological saline, and shaken for 4 minutes. Uncoagulated blood on biomedical fabric samples will dissolve in saline, while coagulated blood will still adhere to the fabric samples. Then the biomedical material fabric samples were taken out from the saline solution, and the blood content in the saline solution was analyzed by enzyme-linked immunosorbent assay (ELISA). Absorbance at 540nm. The lower the absorbance, the lower the concentrat...

Embodiment 3

[0041] Embodiment 3: the healing-promoting effect of the biomedical fiber of embodiment 1

[0042] The healing-promoting effect of the biomedical fiber of Example 1.1 was quantified by the following tests. Briefly, two wounds with the same area of ​​4 cm were formed on the skin of an ICR mouse. 2 . Then, one of the wounds was treated with the non-woven fabric made in Example 1.1 and covered the wound, while the other wound was treated with the commercial product KALTOSTAT TM Wounds were treated and covered as a control group. After a period of time, such as 7 days, 14 days, and 21 days, the areas of the two wounds were measured respectively, and the measurement results are listed in Table 1.

[0043] Table I

[0044]

[0045] The biomedical fiber of Example 1.1 exhibits an excellent healing-promoting effect. As shown in Table 1, after 14 days of treatment, the area of ​​the wound treated by the nonwoven fabric made in Example 1.1 was 2 cm 2 , while KALTOSTAT TM The a...

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Abstract

The invention discloses a spinning stock solution and a method for manufacturing biomedical fibers. The spinning stock solution comprises a biological absorbable material which has a bleeding stopping function and a wound healing function, polysaccharide and a solvent, wherein the polysaccharide is selected from a group consisting of hyaluronic acid and gelatin; and the weight ratio of the polysaccharide to the bleeding stopping material in the spinning stock solution is about 0.1 to 3. The method for manufacturing the biomedical fibers comprises the following step: performing wet-type spinning on the spinning solution, so as to obtain the biomedical fibers.

Description

technical field [0001] The present invention relates to a spinning stock solution, and in particular to a spinning stock solution for manufacturing fibers with functions of hemostasis and wound healing. Background technique [0002] Hemostasis during surgery or of injured tissue or bleeding-prone wounds is critical to patient survival. Many hemostatic materials have been developed in the past, such as US Patent Nos. 3,914,413, 3,911,116 and 3,903,268, and US Patent Publication No. 2007 / 0009578. [0003] Haemostatic sponges have been widely used in surgery to promote hemostasis. It is generally believed that the hemostatic effect of the cavernous body is related to the porosity of the cavernous body and its ability to absorb blood. Traditional sponges attach to bleeding sites and absorb large volumes of blood. Because the pores of the spongy body capture a large number of platelets, the blood coagulation mechanism is activated to stop bleeding. However, when the corpus ca...

Claims

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Application Information

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Patent Type & Authority Patents(China)
IPC IPC(8): D01D1/02D01D5/06A61L15/28A61L15/64
Inventor 杨正义李瑞生彭志刚
Owner TAIWAN TEXTILE RESEARCH INSTITUTE
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